Science Magazine
Watch a robot made of robots move around  Science Magazine · 9 hours
Robot “swarm” can travel around, even though its individual parts cannot more
[Research Articles] Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum  Science Magazine · 10 hours
Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide... more
[Editors' Choice] Interception! A decoy scaffold disrupts autoimmunity  Science Magazine · 10 hours
Subcutaneous implantation of microporous collagen scaffolds decorated with a model autoantigen prevents onset of autoimmune encephalomyelitis in mice. more
[Editors' Choice] PD-L2 in follicular lymphoma: Sidekick or star?  Science Magazine · 10 hours
Immune profiling of follicular lymphoma reveals a role for PD-L2 expression in predicting early progression and survival. more
[Editors' Choice] You (dont) give me fever  Science Magazine · 10 hours
A baseline transcriptional signature in peripheral blood is associated with protection from febrile malaria in children. more
[Research Articles] Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa  Science Magazine · 10 hours
One of the most successful HIV vaccines to date, the RV144 vaccine tested in Thailand, demonstrated correlates of protection including... more
Multiplexed analysis of the secretin-like GPCR-RAMP interactome  Science Magazine · 10 hours
Receptor activity–modifying proteins (RAMPs) have been shown to modulate the functions of several G protein–coupled receptors (GPCRs), but potential direct interactions among the three known RAMPs and hundreds of GPCRs have never been investigated.... more
Porosity production in weathered rock: Where volumetric strain dominates over chemical mass loss  Science Magazine · 10 hours
Weathering in the critical zone causes volumetric strain and mass loss, thereby creating subsurface porosity that is vital to overlying ecosystems. We... more
Could revenue recycling make effective carbon taxation politically feasible?  Science Magazine · 10 hours
Carbon taxes are widely regarded as a potentially effective and economically efficient policy instrument for decarbonizing the global energy supply and thus limiting global warming. The main obstacle is political... more
The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria  Science Magazine · 10 hours
Erythropoietic protoporphyria (EPP) is an inherited disease caused by loss-of-function mutations of ferrochelatase, an enzyme in the heme biosynthesis pathway that converts... more
Structural basis of sterol recognition by human hedgehog receptor PTCH1  Science Magazine · 10 hours
Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog... more
Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis  Science Magazine · 10 hours
Mitochondria are highly dynamic organelles. Through a large-scale in vivo RNA interference (RNAi) screen that covered around a quarter of... more
Learning to read recycles visual cortical networks without destruction  Science Magazine · 10 hours
Learning to read is associated with the appearance of an orthographically sensitive brain region known as the visual word form area. It has been claimed that development of this area... more
Simulation of Eocene extreme warmth and high climate sensitivity through cloud feedbacks  Science Magazine · 10 hours
The Early Eocene, a period of elevated atmospheric CO2 (>1000 ppmv), is considered an analog for future climate. Previous modeling attempts have been unable... more
Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer  Science Magazine · 10 hours
Disrupting the interactions between Hsp90 and Cdc37 is emerging as an alternative and specific way to regulate the Hsp90 chaperone cycle in a manner not involving adenosine triphosphatase... more
SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors  Science Magazine · 10 hours
The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic target. CDK4/6 inhibitors are being evaluated in trials for melanoma and additional cancers. While beneficial, resistance... more
Senate bill would give NIH $3 billion in 2020, or 7.7% boost  Science Magazine · 12 hours
Increase is $1 billion more than the House of Representatives has proposed more
Rock-munching sea urchins have self-sharpening teeth  Science Magazine · 13 hours
Knifelike gnashers could help scientists design tools that rarely need honing more
Study on DNA spread by genetically modified mosquitoes prompts backlash  Science Magazine · 1 day
Company and some scientists dispute suggestion that released strain may have made local mosquitoes fitter more
Massive, blimplike experiment lowers weight limit on neutrino  Science Magazine · 2 days
Physicist still don’t know the particle’s mass, but they’ve halved the possible range more
Biomimetic composites with enhanced toughening using silk-inspired triblock proteins and aligned nanocellulose reinforcements  Science Magazine · 5 days
Silk and cellulose are biopolymers that show strong potential as future sustainable materials. They also have complementary properties, suitable for combination in... more
Size-dependent thermodynamic structural selection in colloidal crystallization  Science Magazine · 5 days
Nucleation and growth of crystalline phases play an important role in a variety of physical phenomena, ranging from freezing of liquids to assembly of colloidal particles. Understanding these processes in the context of colloidal... more
Flexible graphene photodetectors for wearable fitness monitoring  Science Magazine · 5 days
Wearable health and wellness trackers based on optical detection are promising candidates for public health uses due to their noninvasive tracking of vital health signs. However, so far, the use of rigid technologies hindered... more
Optical generation of high carrier densities in 2D semiconductor heterobilayers  Science Magazine · 5 days
Controlling charge density in two-dimensional (2D) materials is a powerful approach for engineering new electronic phases and properties. This control is traditionally realized by electrostatic gating. Here, we... more
Quantum Hall-based superconducting interference device  Science Magazine · 5 days
We present a study of a graphene-based Josephson junction with dedicated side gates carved from the same sheet of graphene as the junction itself. These side gates are highly efficient and allow us to modulate carrier density along... more
Analysis of hygroscopic self-shaping wood at large scale for curved mass timber structures  Science Magazine · 5 days
The growing timber manufacturing industry faces challenges due to increasing geometric complexity of architectural designs. Complex and structurally efficient curved geometries are... more
Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics  Science Magazine · 5 days
NIR-II fluorescence imaging greatly reduces scattering coefficients for nearly all tissue types at long wavelengths, benefiting deep tissue imaging. However, most of the NIR-II fluorophores suffer from low... more
Unfolding adsorption on metal nanoparticles: Connecting stability with catalysis  Science Magazine · 5 days
Metal nanoparticles have received substantial attention in the past decades for their applications in numerous areas, including medicine, catalysis, energy, and the environment. Despite these applications, the fundamentals of adsorption... more
3D-printed automation for optimized PET radiochemistry  Science Magazine · 5 days
Reproducible batch synthesis of radioligands for imaging by positron emission tomography (PET) in a manner that maximizes ligand yield, purity, and molar activity, and minimizes cost and exposure to radiation, remains a challenge, as new and... more
Paramagnon drag in high thermoelectric figure of merit Li-doped MnTe  Science Magazine · 5 days
Local thermal magnetization fluctuations in Li-doped MnTe are found to increase its thermopower α strongly at temperatures up to 900 K. Below the Néel temperature (TN ~ 307... more
Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer  Science Magazine · 5 days
IL-6 inhibits the expression of IL-2Rβ (CD122) in germinal center TFH cells to maintain IL-2 hyporesponsiveness (see the related Research... more
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