Pharmaceuticals
New tool in fight against malaria  SCIENCE DAILY · 3 hours
Modifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs. more
Medical News Today: Cancer: Why drug testing needs to improve  MNT · 5 hours
A new study finds that many new cancer drugs may not work in the way their developers think they do, which could have implications for their effectiveness. more
Combination therapies could help treat fatal lung cancers  SCIENCE DAILY · 6 hours
Combining a new class of drug with two other compounds can significantly shrink lung tumors in mice and human cancer cells, new research shows. The study looked at G12C KRAS inhibitors, a... more
Antibiotic resistance is transferring from humans to animals  NEWS MEDICAL · 6 hours
Resistance to antibiotics could be moving from humans to animals, research by a Clemson University professor has shown. The research details results that demonstrate reverse zoonosis, a process by which humans infect... more
Will combo pill catch on in US to prevent heart attacks?  ABC NEWS · 7 hours
A cheap, daily pill that combines four blood pressure and cholesterol drugs has been tested for the first time in the US to see if it... more
Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin  PHYS.ORG · 7 hours
In the future, you could be your very own fountain of youth—or at least your own skin repair reservoir. In a proof-of-concept... more
[Research Articles] Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum  Science Magazine · 9 hours
Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide... more
[Research Articles] Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa  Science Magazine · 9 hours
One of the most successful HIV vaccines to date, the RV144 vaccine tested in Thailand, demonstrated correlates of protection including... more
New drug target in fight against cancer  SCIENCE DAILY · 10 hours
Researchers have discovered how a cancer-linked version of the protein mitoNEET can close voltage-dependent anion channels (VDAC), primary gateways in the outer surface of mitochondria. The researchers detail how mitoNEET regulates VDAC, and they... more
Fast MRIs offer alternative to CT scans for pediatric head injuries  SCIENCE DAILY · 10 hours
Researchers have released a study that shows that a new imaging method 'fast MRI' is effective in identifying traumatic brain injuries in children, and can avoid... more
Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant  NEWS MEDICAL · 10 hours
A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S.... more
Multiplexed analysis of the secretin-like GPCR-RAMP interactome  Science Magazine · 10 hours
Receptor activity–modifying proteins (RAMPs) have been shown to modulate the functions of several G protein–coupled receptors (GPCRs), but potential direct interactions among the three known RAMPs and hundreds of GPCRs have never been investigated.... more
The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria  Science Magazine · 10 hours
Erythropoietic protoporphyria (EPP) is an inherited disease caused by loss-of-function mutations of ferrochelatase, an enzyme in the heme biosynthesis pathway that converts... more
SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors  Science Magazine · 10 hours
The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic target. CDK4/6 inhibitors are being evaluated in trials for melanoma and additional cancers. While beneficial, resistance... more
Psoriasis drug could be repurposed to treat osteosarcoma  NEWS MEDICAL · 11 hours
A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings from the Garvan Institute of Medical Research suggest. more
Researchers create first protein-engineered hydrogel  NEWS MEDICAL · 11 hours
Imagine a perfectly biocompatible, protein-based drug delivery system durable enough to survive in the body for more than two weeks and capable of providing sustained medication release. more
NUS chemists develop new anti-cancer drug with less renal toxicity  NEWS MEDICAL · 11 hours
A team of pharmacists and chemists from the National University of Singapore has developed a new anti-cancer drug that has less toxic effects to the kidneys. more
Alarming number of life-threatening heart infections related to drug abuse  NEWS MEDICAL · 12 hours
As the nationwide opioid epidemic continues, more young people are developing a life-threatening heart infection that can result from drug abuse. more
The rise, fall and resurgence of gene therapy  PHYS.ORG · 12 hours
Twenty years ago, scientists and investors were giddy over the promise of gene therapy to cure a host of deadly diseases. But the tragic death of a young man from an experimental... more
Cancer cells turn to cannibalism to survive chemotherapy, study suggests  SCIENCE DAILY · 13 hours
Researchers have discovered that some cancer cells survive chemotherapy by eating their neighboring tumor cells. The study suggests that this act of cannibalism provides these cancer cells with... more
Psoriasis drug target offers potential for osteosarcoma  SCIENCE DAILY · 14 hours
A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings suggest. more
Drug delivery: Thermo-responsive protein hydrogel  SCIENCE DAILY · 14 hours
Bio-engineering researchers have created a biocompatible, protein-based hydrogel that could serve as a drug delivery system durable enough to survive in the body for more than two weeks while providing sustained medication release. The research advances an area... more
'Death Star' bacterial structures that inject proteins can be tapped to deliver drugs  SCIENCE DAILY · 15 hours
Not all bacteria spread diseases, many are beneficial and this strain has nanoscale syringes that deliver proteins which cause metamorphosis in marine... more
A Trojan horse approach could lead to treatments for some antibiotic-resistant bacteria  PHYS.ORG · 15 hours
A deadly, antibiotic-resistant bacterium can be sterilized by hijacking its heme-acquisition system, which is essential for its survival. The new strategy, developed by Nagoya... more
Radiation may lower potential for side effects of CAR T therapy in non-hodgkin's lymphoma  SCIENCE DAILY · 15 hours
Treating non-Hodgkin's lymphoma (NHL) patients with radiation therapy as an additional treatment while they wait for their CAR T cells... more
Ultra-pure porous plastic materials for most challenging healthcare applications  NEWS MEDICAL · 15 hours
A new state-of-the-art automated manufacturing system is enabling Porvair Sciences to produce ultra-pure porous plastics that are fully compliant with FDA, USP Class VI and European Pharmacopoeia statutory regulations as... more
New grant to improve use of bDMARDS through a consortium approach  NEWS MEDICAL · 15 hours
A new grant to improve the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs) will see NPS MedicineWise and consortium partners support specialist prescribers and help consumers... more
Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs  SCIENCE DAILY · 16 hours
In a small safety and feasibility clinical trial, researchers have demonstrated for the first time that senescent cells can be removed from the body... more
Alarming number of heart infections tied to opioid epidemic  SCIENCE DAILY · 16 hours
As the nationwide opioid epidemic continues, more young people are developing a life-threatening heart infection that can result from drug abuse. It predominantly affects young, white, poor men who also... more
Parafricta to supply all customers directly from 1st October 2016  NEWS MEDICAL · 17 hours
Frontier Therapeutics Ltd and APA Parafricta Ltd today announced that their exclusive agreement for the distribution of Parafricta® low-friction garments in the UK is to end on September... more
Tree-planting to offset carbon emissions: no cure-all  PHYS.ORG · 19 hours
A few euros, a couple of mouse clicks and a tree is planted—as air travel is increasingly becoming a source of guilt, consumers and companies are looking for other ways to ease their conscience... more
Researchers develop thermo-responsive protein hydrogel  PHYS.ORG · 21 hours
Imagine a perfectly biocompatible, protein-based drug delivery system durable enough to survive in the body for more than two weeks and capable of providing sustained medication release. An interdisciplinary research team led by Jin Kim Montclare, a professor... more
Text messaging, electric pill bottles not enough to drive down blood pressure levels  NEWS MEDICAL · 22 hours
About one in three Americans have high blood pressure, called hypertension, but only about half of them have their condition under control. more
UT Southwestern researchers identify novel mechanism that regulates fat formation  NEWS MEDICAL · 23 hours
In work suggesting new therapeutic targets to fight obesity, UT Southwestern researchers have identified a novel mechanism that regulates the creation of fat in mammals. more
New study alters guidelines for management of sepsis  NEWS MEDICAL · 23 hours
A new study that measured the reliability of administering antibiotics before obtaining blood cultures could end the debate among physicians regarding sepsis management. more
New technique for police to quickly and safely test drug evidence  NEWS MEDICAL · 1 day
Scientists have demonstrated a way for police to quickly and safely test whether a baggie or other package contains illegal drugs without having to handle any... more
Purdue Pharma to stay in business as bankruptcy unfolds  ABC NEWS · 1 day
A judge has cleared the way for OxyContin maker Purdue Pharma to stay in business while it pursues bankruptcy protection and settlement of lawsuits more
Novel anti-cancer nanomedicine for efficient chemotherapy  nanowerk · 1 day
Scientists have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. This new nano-tool provides a new approach to use cell-based nanomedicines for effcient cancer chemotherapy. more
'Blood money'? Purdue settlement would rely on opioid sales  ABC NEWS · 1 day
Some of the money in Purdue Pharma's proposed multibillion-dollar opioid settlement would come from the continued sale of opioids more
Electric pill bottles and text messaging not enough to affect blood pressure control  SCIENCE DAILY · 1 day
Blood pressure levels in patients with hypertension did not improve when patients took part in automated texting or were given electronic pill... more
Programmable swarmbots make flexible biological tools  SCIENCE DAILY · 1 day
Biomedical engineers have developed a new platform to create biological drugs using specially engineered bacteria that burst and release useful proteins when they sense that their capsule is becoming too crowded. more
Genomic migration analysis shows antibiotic resistance moving from humans to animals  SCIENCE DAILY · 1 day
New results show that human-acquired antibiotic resistance genes are being transmitted to livestock, companion animals and wildlife. Researchers analyzed a global set of 901 genome sequences... more
New pathway that controls fat formation  SCIENCE DAILY · 1 day
In work suggesting new therapeutic targets to fight obesity, researchers have identified a novel mechanism that regulates the creation of fat in mammals. more
Genomic migration analysis shows antibiotic resistance moving from humans to animals  PHYS.ORG · 1 day
A Clemson University professor's research has documented the movement of antibiotic resistance in humans into animal species. more
Radiation therapy effective against deadly heart rhythm  SCIENCE DAILY · 1 day
A single high dose of radiation aimed at the heart significantly reduces episodes of a potentially deadly rapid heart rhythm, according to results of a phase one/two study. more
Clues to the origin of Huntington's disease, and a new way to find drugs  SCIENCE DAILY · 1 day
Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early... more
A safer way for police to test drug evidence  SCIENCE DAILY · 1 day
Scientists have demonstrated a way for police to quickly and safely test whether a baggie or other package contains illegal drugs without having to handle any suspicious contents directly. The... more
Programmable swarmbots help make flexible biological tools  PHYS.ORG · 1 day
Biomedical engineers at Duke University have developed a new platform to create biologic drugs using specially engineered bacteria that burst and release useful proteins when they sense that their capsule is becoming too crowded. more
Researchers develop new anti-cancer nanomedicine for targeted chemotherapy  NEWS MEDICAL · 1 day
Researchers at the University of Helsinki in collaboration with researchers from Åbo Akademi University, Finland and Huazhong University of Science and Technology, China have developed a new anti-cancer nanomedicine for targeted cancer... more
Cancer cells survive chemotherapy by eating their neighboring tumor cells  NEWS MEDICAL · 1 day
Researchers from the Tulane University School of Medicine have discovered that some cancer cells survive chemotherapy by eating their neighboring tumor cells. more
A safer way for police to test drug evidence  PHYS.ORG · 2 days
Scientists have demonstrated a way for police to quickly and safely test whether a baggie or other package contains illegal drugs without having to handle any suspicious contents directly. The... more
Judge: No custody for parents who didn't want chemo for son  ABC NEWS · 2 days
A Florida judge has ruled that a 4-year-old boy is in imminent danger of neglect if he stays with his parents because of their desire to... more
Cause of rare, fatal disorder in young children pinpointed  SCIENCE DAILY · 2 days
Scientists appear to have solved a decades-long mystery regarding the precise biochemical pathway leading to a fatal genetic disorder in children that results in seizures, developmental regression and death, usually... more
Novel anti-cancer nanomedicine for efficient chemotherapy  SCIENCE DAILY · 2 days
Researchers have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. This new nano-tool provides a new approach to use cell-based nanomedicines for efficient cancer chemotherapy. more
Nanoscale syringe-like bacterial structures could be used to deliver novel drugs  NEWS MEDICAL · 2 days
By scraping tubeworms off the bottom of boats in the San Diego harbor to study them, San Diego State University researchers discovered that a beneficial bacterium... more
Relearning to walk after stroke using a therapeutic shoe  NEWS MEDICAL · 2 days
A therapeutic shoe engineered to improve stroke recovery is proving successful and expected to hit the market by the end of the year. more
Stroke patients relearning how to walk with peculiar shoe  SCIENCE DAILY · 2 days
Clinical trials have been completed on a therapeutic shoe engineered to improve stroke recovery. They've proven successful, allowing for the patented product to hit the market by the end of... more
Later puberty and later menopause associated with lower risk of type 2 diabetes in women  SCIENCE DAILY · 2 days
New research shows that use of the contraceptive pill and longer menstrual cycles are associated with a higher... more
Longtime crusader against Oxycontin begins to see the fruits of her struggle  NEWS MEDICAL · 2 days
In the 15 years since she lost her son to a single OxyContin pill, Barbara Van Rooyan has had but one up-close look at... more
Hair indicates whether wild animals were 'stressed'  PHYS.ORG · 2 days
While hair analysis has become routine in humans—for example for the detection of prolonged drug or medication abuse—it has been little used in animals to date. Scientists led by Alexandre Azevedo and Katarina Jewgenow... more
Diamonds are forever: New foundation for nanostructures  PHYS.ORG · 2 days
Devices smaller than the width of a human hair are key to technologies for drug delivery, semiconductors, and fuel production. But current methods for fabricating these micro- and nanostructures can be expensive and wasteful. more
Pre-SRT PSA could serve as prognostic and predictive biomarker of benefit from hormone therapy  NEWS MEDICAL · 2 days
Initial results of NRG Oncology Clinical Trial RTOG 9601 in men with biochemically recurrent prostate cancer receiving salvage radiotherapy demonstrated... more
'Death Star' bacterial structures that inject proteins can be tapped to deliver drugs  nanowerk · 2 days
Not all bacteria spread diseases, many are beneficial and this strain has nanoscale syringes that deliver proteins which cause metamorphosis in marine... more
Synthetic cells capture and reveal hidden messages of the immune system  SCIENCE DAILY · 2 days
New research is highly relevant to how antibodies are made in response to infections, vaccines and in autoimmunity due to the its analysis of a signal... more
Radiation therapy reduces episodes of deadly rapid heart rhythm  NEWS MEDICAL · 2 days
A single high dose of radiation aimed at the heart significantly reduces episodes of a potentially deadly rapid heart rhythm, according to results of a phase one/two study at Washington... more
Bioengineering organ-specific tissues with high cellular density and embedded vascular channels  PHYS.ORG · 2 days
Bioengineers study the development of organ-specific tissues in the lab for therapeutic applications. However, the process is highly challenging, since it requires the fabrication and maintenance... more
Common drug source of insights into formation of 'butterfly' crystals  PHYS.ORG · 2 days
Experiments at ANSTO's Australian Centre for Neutron Scattering and the Australian Synchrotron have revealed the growth mechanism behind an unusual twin crystal that forms conjoined "wings" in the... more
Drug-sparing HIV regimens have become new standards of care, says GlobalData  NEWS MEDICAL · 2 days
Reductions in pill burden and dosing, improvements in safety and tolerability, and increased barriers to resistance have changed HIV management. more
Researchers identify potential target for diabetes-associated Alzheimer's disease  NEWS MEDICAL · 2 days
Researchers have identified a protein that may contribute to the progression of Alzheimer’s disease pathology in type-2 diabetes, reports a new study of male mice and human brain tissue. The research could... more
Inherited genetic tendency appears to protect people from MRSA infections  NEWS MEDICAL · 2 days
An inherited genetic tendency appears to increase the likelihood that a person can successfully fight off antibiotic-resistant staph infections, according to a study led by Duke Health researchers. more
New method developed to address failures in promising anti-cancer drug  NEWS MEDICAL · 2 days
Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science... more
Cure for Rett Syndrome a step closer as scientists successfully reactivate 'back-up’ genes  NEWS MEDICAL · 2 days
A team headed by Vincent Pasque at his Lab at KU Leuven alongside researchers from the Jean-Christophe Marine lab and the Edith... more
Scientists prove low cost arthritis drug can effectively treat blood cancer sufferers  SCIENCE DAILY · 2 days
A simple arthritis drug could be an effective, low cost solution to treat patients with blood cancers such as polycythemia vera (PV) and essential... more
Medical News Today: Way to prevent chemotherapy hair loss in sight  MNT · 2 days
Using a mini organ model, scientists reveal how taxane chemotherapy can permanently damage hair follicles, and how a newer class of drug could prevent it. more
New therapeutic target for rheumatoid arthritis and type 2 diabetes  NEWS MEDICAL · 2 days
There is a growing body of knowledge that points that type 2 diabetes, a chronic disease where the blood sugar increases, is an inflammatory disease. The levels of... more
Off-label medication orders on the rise for children  SCIENCE DAILY · 2 days
US physicians are increasingly ordering medications for children for conditions that are not approved by the Food and Drug Administration, according to a new study. The findings highlight the need for more... more
Antibiotic resistance in dolphins mirrors disturbing trend in humans  NEWS MEDICAL · 2 days
Antibiotic resistance in bottlenose dolphins shows that up to 88% of pathogenic organisms in this species is resistant to one or more antibiotics. This finding offers very useful insights into... more
Uncovering new T cell regulatory processes could help treat autoimmune disease  NEWS MEDICAL · 2 days
One of the important cells involved in the immune response is the T follicular helper (Tfh) cell. These are important in the normal process of antibody... more
Genetically engineered plasmid can be used to fight antimicrobial resistance  SCIENCE DAILY · 2 days
Researchers have engineered a plasmid to remove an antibiotic resistance gene from the Enterococcus faecalis bacterium, an accomplishment that could lead to new methods for combating antibiotic resistance. more
Big data, bench science suggests drug may slow Parkinson's progression in people  SCIENCE DAILY · 2 days
A drug used to treat enlarged prostate may also slow the progression of Parkinson's disease, according to a new study. more
Can Purdue Pharma's opioid settlement win judge's approval?  ABC NEWS · 2 days
OxyContin maker Purdue Pharma says its bankruptcy filing is not a way to seek refuge but rather an effort to resolve claims against it more
The Latest: First hearing set on Purdue bankruptcy  ABC NEWS · 2 days
Lawyers representing local governments say claims blaming the drug industry for the opioid crisis will continue even after one key company filed for bankruptcy protection more
Stanford-UCSF researchers report new cure for common cold in human cells and mice  NEWS MEDICAL · 2 days
Temporarily disabling a single protein inside our cells might be able to protect us from the common cold and other viral diseases,... more
New sample holder for protein crystallography  PHYS.ORG · 2 days
Proteins are huge molecules that often have complex three-dimensional structure and morphology that can include side chains, folds, and twists. This three-dimensional shape is often the determining factor of their function in organisms. It is therefore... more
Genetically engineered plasmid can be used to fight antimicrobial resistance  PHYS.ORG · 2 days
Researchers have engineered a plasmid to remove an antibiotic resistance gene from the Enterococcus faecalis bacterium, an accomplishment that could lead to new methods for combating antibiotic resistance.... more
What you eat may change the way that antibiotics affect your gut  NEWS MEDICAL · 2 days
Scientists have examined how antibiotics change the gut bacteria in mice and looked at how diet may exacerbate or mitigate these changes. more
NYU Langone performs first-ever foot and ankle arthroscopic procedure with new camera system  NEWS MEDICAL · 2 days
NYU Langone Health recently became the first ever health system to perform a foot and ankle arthroscopic procedure with a new camera... more
Acute therapy with vitamin E may offer effective low-cost treatment for heart attack  NEWS MEDICAL · 3 days
Heart attack is a leading cause of death worldwide and new treatment strategies are highly sought-after. Unfortunately lasting damage to the heart... more
'Once you have it, you need it': Opioid epidemic still rages  ABC NEWS · 3 days
As lawyers exchange mountains of paper and dicker over the details of a settlement with OxyContin maker Purdue Pharma, Americans are dying from opioids by the... more
The Latest: Other opioid claims move ahead amid bankruptcy  ABC NEWS · 3 days
Lawyers representing local governments say claims blaming the drug industry for the opioid crisis will continue even after one key company filed for bankruptcy protection more
Experts offer insights into new class of migraine medications  NEWS MEDICAL · 3 days
As research continues to show progress towards minimizing the effects of headache disorders on patients' lives, Practical Neurology gathered insights from experts in the field at The American Headache Society... more
Transplanted brain stem cells survive without anti-rejection drugs in mice  SCIENCE DAILY · 3 days
In experiments in mice, researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs. more
Researchers find new way to find antibiotics in dirt  PHYS.ORG · 3 days
Researchers at McMaster have designed a new way to rapidly identify antibiotics hidden in common dirt. more
Researchers eliminate need for anti-rejection drugs in mice with transplanted glial cells  NEWS MEDICAL · 3 days
In experiments in mice, Johns Hopkins Medicine researchers say they have developed a way to successfully transplant certain protective brain cells without the need... more
Breakthrough in harnessing the power of biological catalysts  PHYS.ORG · 3 days
The power of nature could soon be used to create day-to-day materials such as paints, cosmetics and pharmaceuticals in a much more environmentally friendly way, thanks to a new breakthrough from scientists. more
How can evolutionary biology help to get rid of antibiotic resistant bacteria?  PHYS.ORG · 3 days
Craig MacLean, Professor of Evolution and Microbiology at Oxford's Department of Zoology, explains how evolutionary biology can help us to get rid of antibiotic... more
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