Pharmaceuticals
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper like transcription regulator 1 (LZTR1) gene led...
Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are often central to pharmacological function. We present an alternative approach to metal-catalyzed cross-coupling to make heterobiaryls...
PharmaceuticalsHealth more... Science Magazine 6 minutes
If pharmaceutical chemists are the drug hunters who discover new medicines, scientists like Andrew McNally and Robert Paton are the armorers—the deft creators who arm drug hunters with...
Genetically engineered microbes such as bacteria and yeasts have long been used as living factories to produce drugs and fine chemicals. More recently, researchers have started to combine bacteria with semiconductor technology that, similar to solar...
Microbes equipped with light-harvesting semiconductor particles generate useful chemicals much more efficiently than ordinary microbes.
Improved drug delivery method is aimed at making chemotherapy easier to help treat people with various tumors.
Purdue University researchers have developed a technology aimed at making it easier to deliver cancer treatment to the right "address" in the...
The Peptides and Proteins lab at the Institute for Research in Biomedicine (IRB Barcelona) has published a paper in Chemical Communications describing the use of a peptide derived from chlorotoxin, found in...
The siren call of addictive drugs can be hard to resist, and returning to the environment where drugs were previously taken can make resistance that much harder. However, addicts who exercise appear to be...
Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumors disappear in mice, making it...
Currently in India, there are over 200,000 researchers working on numerous applications to better...
The kambo cleanse is a South American ritual that uses the poison of the giant monkey frog to boost energy and cure illnesses. We take a...
An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers at the University of Zurich have now found that this happens through a previously unknown mechanism....
Research led by the University of Bristol has begun to unpick an important mechanism of antibiotic resistance and suggest approaches to block this resistance.
Researchers have found that a protein in the cell membranes of sperm plays a key role in how they find their way to eggs. The PMCA protein may also help...
RetiPharma, focusing on the development of products for the treatment of degenerative eye disorders based on an in vivo platform for translation...
DiseasesPharmaceuticalsHealth more... NEWS MEDICAL 6 hours
Widespread antimicrobial resistance (AMR) and the associated rise of "superbugs" is a major public health threat. A leading cause is the misuse or overuse of antibiotics...
An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers at the University of Zurich have now found out that this happens through a previously unknown...
Many life-saving medicines, including insulin, antibodies and vaccines, are derived from living cells. These "biologics" can be difficult to obtain and store...
If patient engagement is the new 'blockbuster drug,' why are we not seeing spectacular effects? A team of researchers from The Dartmouth Institute for Health Policy and Clinical...
Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic...
The U.S. Food and Drug Administration today alerted health care providers and patients about the serious complications that can occur when using medications not approved for...
A new special edition of the International Journal of Radiation Oncology* Biology* Physics focuses on the roles of imaging in radiation oncology....
The use of a new class of drugs in the treatment of type 2 diabetes, so called SGLT2 inhibitors, are linked to a twofold...
DiabetesPharmaceuticals more... NEWS MEDICAL 14 hours
Researchers have made rapid advances in understanding how to manipulate the immune system safely to destroy cancer cells. Adoptive transfer of haploidentical natural killer...
Cancer more... NEWS MEDICAL 16 hours
Two new studies provide evidence that previous Dengue infection in pregnant mothers may lead to increased...
Zika virusInfections more... SCIENCE DAILY 17 hours
With Thanksgiving approaching, food safety officials are stressing the importance of proper handling and cooking practices as a nationwide outbreak of drug-resistant Salmonella found in raw turkey expands
more... ABC NEWS 21 hours
Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine...
DiabetesPain more... PHYS.ORG 23 hours
Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution...
RelativityGravityInfectionsUniverse more... Science Magazine 24 hours
A third of the global population relies heavily upon traditional or folk medicines, such as the...
Space StationsEarth's Orbit more... Science Magazine 24 hours
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important...
Infections more... Science Magazine 24 hours
We report the development of a novel platform to enhance the efficacy and safety of follicular lymphoma (FL) treatment. Since lymphoma is a clonal malignancy of a diversity...
CarsCancer more... Science Magazine 24 hours
The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major challenge for clinicians. We...
Cancer more... Science Magazine 24 hours
Oral administration of therapeutic peptides is hindered by poor absorption across the gastrointestinal barrier and extensive degradation by proteolytic enzymes. Here, we investigated the...
TabletsAnimalsDogs more... Science Magazine 24 hours
RB1 loss of function in small cell lung cancer causes dependency on Aurora kinases for survival, which can be targeted therapeutically.
Cancer more... Science Magazine 24 hours
Many life-saving medicines, including insulin, antibodies and vaccines, are derived from living cells. These "biologics" can be difficult to obtain and store on the battlefield or in remote areas. That's why scientists are trying to develop portable systems that can...
The siren call of addictive drugs can be hard to resist, and returning to the environment where drugs were previously taken can make resistance that much harder.
Addiction more... NEWS MEDICAL 1 day
The siren call of addictive drugs can be hard to resist, and returning to the environment where drugs were previously taken can make resistance that much harder. However, addicts who exercise appear to be...
Addiction more... PHYS.ORG 1 day
New results from a long-running trial to identify which new drugs or combinations of drugs are most effective in which types of breast cancer,...
Cancer more... NEWS MEDICAL 1 day
Doctors prescribe gabapentin to treat epilepsy, restless legs syndrome, and some types of nerve pain. Learn more about the uses and potential side effects here.
Pain more... MNT 1 day
The cattle tick is controlled by pesticides, invariably leading to the selection of resistant strains. In Brazil, this parasite is currently resistant to a greater or lesser extent to all...
Animals more... PHYS.ORG 1 day
Doctors prescribe gabapentin to treat epilepsy, restless legs syndrome, and some types of nerve pain. Learn more about the uses and potential side effects here.
Pain more... MNT 1 day
Three-quarters of prisoners struggling to sleep have reported major improvements to their sleep and wellbeing after receiving cognitive behavioral therapy to treat their insomnia.
Sleep more... NEWS MEDICAL 1 day
A new clinical trial finds that a novel drug can boost the strength of radiation therapy in the fight against cancer with 'minimal side effects.'
Alcohol advertisements on social media sites such as Facebook can increase young adults' desire to drink if the ads contain pro-drinking comments...
National Institutes of Health scientists and their collaborators found that hepatitis B virus-associated acute liver failure--a rare condition that can turn fatal within days without liver...
Infections more... NEWS MEDICAL 1 day
Before patients receive intravenous antimicrobial infusion therapy outside of the hospital - whether at home, a doctor's office or a skilled nursing...
HospitalsInfections more... NEWS MEDICAL 1 day
The most aggressive type of prostate cancer, castration-resistant prostate cancer, can be treated with two different therapies: taxanes or hormone treatment. Until this day there are...
Cancer more... NEWS MEDICAL 1 day
Old age is the greatest risk factor for many diseases, including Alzheimer's disease (AD) and cancer. Geroprotectors are a recently identified class...
Enable Injections, Inc., a patient-centric drug delivery combination product company developing advanced wearable devices for subcutaneous delivery of high-volume therapeutics, today announced it has entered into...
more... NEWS MEDICAL 2 days
A new antibiotic hailed as the "last line of defense" in the battle against drug-resistant superbugs such as MSRA and VRE is...
Superbug more... NEWS MEDICAL 2 days
An antibody that binds simultaneously to two distinct regions of the HER2 receptor to block the growth of cancer cells has shown...
Cancer more... NEWS MEDICAL 2 days
Scientists have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results showed that DMAbs were expressed over a wide window of...
Clean EnergyInfections more... SCIENCE DAILY 2 days
Opioid-related overdoses and deaths remain a major public health concern in Massachusetts, yet adolescents who experience opioid-related nonfatal overdose have been rarely studied.
Drugs & AlcoholAddiction more... NEWS MEDICAL 2 days
Healthcare professionals nationwide are gathering this week to discuss how to improve programs to better control antibiotic use in healthcare facilities.
more... NEWS MEDICAL 2 days
Researchers have provided new insight on the mechanisms behind the development of clear cell Renal Cell Carcinoma (ccRCC), according to new findings published in...
Cancer more... NEWS MEDICAL 2 days
For people with conditions such as cystic fibrosis and COPD, mucus can get too thick and sticky; coughing alone can't...
Infections more... SCIENCE DAILY 2 days
Old age is the greatest risk factor for many diseases, including Alzheimer's disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New research has...
Enbrel and Humira are medications that doctors prescribe to treat rheumatoid arthritis and other conditions. Both help lower inflammation in the joints and are similar, regarding their available forms, storage, and costs....
more... MNT 2 days
Scientists paired drug-delivering nanoparticles like dance partners to reveal that molecules attach to targets on cells differently based upon their position in time. The discovery could improve methods...
more... SCIENCE DAILY 2 days
Scientists watch the 'swirling and spinning' of therapeutic nanoparticles to better understand their cellular binding.
more... nanowerk 2 days
Bioengineers have combined a virus that infects moths with magnetic nanoparticles to create a potential new therapy for inherited genetic diseases like muscular dystrophy, sickle cell, cystic fibrosis, spinal muscular atrophy and some forms of cancer.
InfectionsCancer more... SCIENCE DAILY 2 days
Psoriatic arthritis (PsA) causes pain and inflammation of the joints. Many people with PsA also experience the red, scaly rash that is characteristic of psoriasis. Treatments for the...
Pain more... MNT 2 days
There are four major types of anxiety medication as well as other drugs that a doctor may prescribe off-label. Learn about how they work and the...
more... MNT 2 days
Scientists at the University of Southampton have developed a new antibody that could hold the key to unlocking cancer's defense against the body's immune system.
Cancer more... NEWS MEDICAL 2 days
A team of scientists from the Far Eastern Federal University and Korea Universityobtained cobalt and cobalt-iron nanosprings with unique combined magnetic properties and long-lasting elasticity that...
more... NEWS MEDICAL 2 days
Indiana University researchers have discovered that drug-delivering nanoparticles attach to their targets differently based upon their position when they meet—like ballroom dancers who change their moves with the...
more... PHYS.ORG 2 days
A new study shows that food insecurity in pregnant women being treated for opioid use disorder may be associated with increased risk for their infants receiving...
Drugs & AlcoholAddiction more... NEWS MEDICAL 2 days
Experimental therapy could repair mutations that cause genetic diseases.
more... nanowerk 2 days
Scientists obtained nanosprings that may be used to develop nanorobots and targeted drug delivery agents.
more... nanowerk 2 days
Donald Trump has waved the words "stop and frisk" around like a banner call to cure violent crime in American cities.
Crime more... PHYS.ORG 2 days
Clergy members have become spiritual first responders in the opioid crisis, often leaving the pulpit to minister on the streets
A new technology that relies on a moth-infecting virus and nanomagnets could be used to edit defective genes that give rise to diseases like sickle cell, muscular dystrophy and cystic...
Resistance to antibiotics and pesticides is rising at alarming rates. Yet, currently, there is no global framework to track the threat to human health and crops. Researchers have now published the first...
Animals more... PHYS.ORG 2 days
Sports concussions, Parkinson's disease, and hormone therapy for cancer - all can have memory loss as symptoms. But do the biochemical processes of each type of memory loss have anything...
AlzheimersDementiaCancer more... NEWS MEDICAL 2 days
Drugs that inhibit a hormone that constricts blood vessels also help improve sodium excretion in blacks who hold onto too much sodium in the face of stress, investigators report.
more... NEWS MEDICAL 2 days
German chemicals and pharmaceuticals giant Bayer confirmed its full-year forecasts Tuesday, after a solid performance in the firm's first full quarter of integrating US seeds and pesticides maker Monsanto.
AnimalsTech Business more... PHYS.ORG 2 days
VP Pence's wife announced a $54,000 grant to a teacher at a Japanese university for the study of art therapy, the profession Pence has chosen as her cause...
more... ABC NEWS 2 days
As prescriptions for psychotropic drugs increase, researchers at the University of Colorado Anschutz Medical Campus have found that prescribed access to anti-anxiety and anti-psychotic medications may...
more... NEWS MEDICAL 2 days
Nearly two thirds of Americans (65%) say antibiotic resistance is a public health problem and a strong majority (81%) say they are...
Infections more... NEWS MEDICAL 2 days
The World Health Organization (WHO) has released a notification regarding antibiotic usage and resistance this week. The organization has warned that some countries have a very high consumption of antibiotics and there...
more... NEWS MEDICAL 3 days
Clergy members become spiritual first responders in the opioid crisis
Researchers have now published the first estimates of antibiotic and pesticide 'planetary boundaries.' The researchers suggest that if resistance to antibiotics and pesticides goes beyond these boundaries, societies risk large-scale health and...
AnimalsInfections more... SCIENCE DAILY 3 days
Heart disease is the leading cause of death in the U.S. A group of physicians at Johns Hopkins Medicine and the American Heart Association have released...
more... ABC NEWS 3 days
A research team describes a newly discovered mechanism. The findings shed new light on our immune systems -- and also pave the way for drug delivery techniques to...
Infections more... SCIENCE DAILY 3 days
Scientists have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If...
more... SCIENCE DAILY 3 days
Immunotherapy drugs target molecule that speeds cancer growth in overweight people
Obesity more... Science Magazine 3 days
When it comes to reducing inflammation to decrease the risk of heart disease and stroke, results from the much-anticipated Cardiovascular Inflammation Reduction Trial indicate that targeting...
more... NEWS MEDICAL 3 days
Experts from across Europe have developed a set of competencies in antimicrobial prescribing and stewardship, using a structured consensus procedure.
more... NEWS MEDICAL 3 days
The U.S. Food and Drug Administration today announced that, on behalf of the agency, the U.S. Marshals Service has conducted a mass...
Animals more... NEWS MEDICAL 3 days
Today, the U.S. Food and Drug Administration announced that an emergency use authorization has been issued for a rapid, single-use test for the detection...
Infections more... NEWS MEDICAL 4 days
A team of Salk Institute researchers led by President Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen...
AlzheimersAging more... NEWS MEDICAL 4 days
A widely anticipated study has concluded that neither vitamin D nor fish oil supplements prevent cancer or serious heart-related problems...
Animals more... NEWS MEDICAL 4 days
A drug therapy used for patients with chronic heart failure also improves markers of poor prognosis in individuals who are hospitalized with acute heart failure, new Yale-led research...
Hospitals more... NEWS MEDICAL 4 days
Japanese researchers have last week transplanted stem cells into a patient’s brain as part of an experimental therapy for Parkinson’s disease. The team at Kyoto University used induced Pluripotent Stem (iPS) cells...
more... NEWS MEDICAL 4 days
This latest study is the strongest and most definitive examination yet.
Animals more... ABC NEWS 4 days
Common bacteria that cause foodborne diseases are resistant to antibiotics used to treat infections, according to research that identified 39 genes responsible for this resistance.
Infections more... SCIENCE DAILY 5 days
People with, or at high risk of, cardiovascular disease lowered their chances of having a heart attack or stroke with a drug containing an...
Animals more... SCIENCE-NEWS 5 days
How do peptides penetrate cells? Two sides of the same coin
PHYS.ORG
Virtual reality therapy has real-life benefits for some mental disorders
SCIENCE-NEWS
Drought fighter found in soil
PHYS.ORG
CRISPR opens door to new type of medicine—'genome surgery'
PHYS.ORG
MRI tool watches how electrical stimulation could cure digestive disorders
SCIENCE DAILY
A revolutionary treatment for allergies to peanuts and other foods is going mainstream—but do the benefits outweigh the risks?
Science Magazine