Pharmaceuticals
A microdose lithium formulation could halt signs of Alzheimer's pathology  NEWS MEDICAL · 58 minutes
There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer's disease. more
Data from high-quality registries to be considered in benefit assessment of drugs  NEWS MEDICAL · 2 hours
Particularly in the case of accelerated drug approvals and drugs for rare diseases (orphan drugs), the evidence available at the time of market access... more
Opioid victims can begin filing claims against Purdue Pharma  ABC NEWS · 4 hours
The federal judge overseeing the bankruptcy case of OxyContin maker Purdue Pharma set a June 30 deadline to file claims against the company more
Taming pathogens with mucus and phages  NEWS MEDICAL · 4 hours
Millions of people are treated with antibiotics each year for infections or as a preventative measure. The Centers for Disease Control and Prevention reports that at least 2.8 million people are infected with antibiotic-resistant bacteria each... more
Opioid dependence found to permanently change brains of rats  SCIENCE DAILY · 4 hours
Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, researchers... more
Individuals can begin filing claims against Purdue Pharma  ABC NEWS · 5 hours
The federal judge overseeing the bankruptcy case of OxyContin maker Purdue Pharma set a June 30 deadline to file a claim against the company more
APRNs have expanded roles in national response to opioid crisis  NEWS MEDICAL · 5 hours
As we enter a new year and a new decade, many states have enacted legislation affecting the roles of advanced practice registered nurses in terms of practice authority,... more
Non-hormonal options are effective in treating menopause symptoms  NEWS MEDICAL · 5 hours
The classic symptoms of menopause – hot flashes, sleeplessness, and vaginal dryness – have typically been treated with estrogen therapy. Studies published today report that non-hormonal options are effective, too. more
APRNs to have expanded roles in national response to opioid crisis  NEWS MEDICAL · 6 hours
As we enter a new year and a new decade, many states have enacted legislation affecting the roles of advanced practice registered nurses in terms of... more
Opioid dependence produces permanent changes in the brains of rats  NEWS MEDICAL · 6 hours
Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. more
Majority of people knowingly use fentanyl, UBC research shows  NEWS MEDICAL · 7 hours
Fentanyl use by people who use drugs has doubled since 2015, and two-thirds of people are aware they've taken it, finds new research out of British Columbia, the Canadian province... more
30-year study of MSUD highlights critical need for more effective disease-modifying therapies  NEWS MEDICAL · 7 hours
A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup... more
How disorder in nanocrystals enables heat-therapeutic systems  nanowerk · 7 hours
Nanocrystals, when they are dressed by the right kind of imperfections, adjust their electronic properties to favorably convert energy into heat, an important attribute for potential use in smart materials for energy, health, sensors... more
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation  Science Magazine · 7 hours
T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high-affinity, isotype-switched antibodies. In a... more
On the design of precision nanomedicines  Science Magazine · 7 hours
Tight control on the selectivity of nanoparticles’ interaction with biological systems is paramount for the development of targeted therapies. However, the large number of tunable parameters makes it difficult to identify optimal design "sweet spots" without... more
Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli  Science Magazine · 7 hours
Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance, virulence, and other traits among bacterial populations. The environmental and genetic forces that drive... more
Researchers explain how disorder in tiny crystals enables heat-therapeutic systems  PHYS.ORG · 9 hours
A new research study at the Institute of Electronic Structure and Lasers (IESL) of the Foundation for Research and Technology-Hellas (FORTH) finds that minute crystals, many thousand times... more
Drug To Prevent Premature Birth Divides Doctors, Insurers And FDA Experts  NPR · 9 hours
An expert panel convened by the FDA says the drug Makena should be withdrawn from the market because a review of its effectiveness shows it doesn't... more
Snake stem cells used to create venom-producing organoids  SCIENCE DAILY · 12 hours
Organoids have become an important tool for studying many disease processes and testing potential drugs. Now, they are being used in a surprising and unexpected way: for the production of snake venom.... more
Tackling antibiotic resistance: Phage-mimicking antibacterial core-shell nanoparticles could help  PHYS.ORG · 13 hours
According to the World Health Organization, one of the biggest health threats around the world is antibiotic-resistant bacteria. Every day people use antibiotics to prevent or fight back against infection,... more
Bayer stock climbs on report of Roundup settlement  PHYS.ORG · 16 hours
Shares in German chemicals and pharmaceuticals giant Bayer climbed Friday on a report it was nearing a $10 billion settlement with US plaintiffs claiming weedkiller Roundup caused their cancer. more
Oral drug may help reduce heavy menstrual bleeding in women with uterine fibroids  NEWS MEDICAL · 1 day
About 50 % of women with uterine fibroids-;non-cancerous muscle tumors that grow in the uterus-;experience heavy menstrual bleeding and other symptoms. more
Ex-pharmaceutical exec gets 5 1/2 years for pushing opioid  ABC NEWS · 1 day
The founder of an Arizona pharmaceutical company has been sentenced to 5 1/2 years in prison for his role in a bribery and kickback scheme that prosecutors said helped fuel... more
Two-drug combo halts the growth of cancer cells  SCIENCE DAILY · 1 day
Researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations. more
Taking aim at gastric cancer  SCIENCE DAILY · 1 day
A novel drug, named 'FerriIridium,' can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching the interior of a tumor cell. This is... more
Urine fertilizer: 'Aging' effectively protects against transfer of antibiotic resistance  SCIENCE DAILY · 1 day
Recycled and aged human urine can be used as a fertilizer with low risks of transferring antibiotic resistant DNA to the environment, according to new research. more
The new front against antibiotic resistance  MIT · 1 day
Deborah Hung shares research strategies to combat tuberculosis as part of the Department of Biology's IAP seminar series on microbes in health and disease. more
Elagolix drug suppresses ovarian hormone production, prevents heavy menstrual bleeding  NEWS MEDICAL · 1 day
About 50 % of women with uterine fibroids--non-cancerous muscle tumors that grow in the uterus--experience heavy menstrual bleeding and other symptoms. Surgery is commonly recommended when these symptoms... more
Researchers identify novel cellular entry factor for AAV vector types  NEWS MEDICAL · 1 day
Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors... more
Mechanism for how common gene therapy vectors enter cells  SCIENCE DAILY · 1 day
Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types -- the most commonly used viral vectors for in vivo gene therapy. The researchers identified that... more
Chemicals in the environment: A focus on mixtures  PHYS.ORG · 1 day
Chemicals have improved our quality of life. But at the same time, they pose a considerable risk for humans and the environment: pesticides, pharmaceuticals and plasticisers enter the environment and the food... more
A two-drug combo that halts growth of cancer cells discovered  NEWS MEDICAL · 1 day
UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations. more
FerriIridium drug can simultaneously help diagnose, treat gastric cancer  NEWS MEDICAL · 1 day
A novel drug, named "FerriIridium", can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching... more
Taking aim at gastric cancer: New approach to selective chemotherapy  PHYS.ORG · 1 day
A novel drug, named "FerriIridium," can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only... more
Patient multimorbidity increases GPs’ likelihood of burnout  NEWS MEDICAL · 1 day
There is a difference between seeing a patient with a catalogue of two or more serious chronic diseases and a healthy patient who just needs a prescription to treat a case of cystitis. more
Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies  NEWS MEDICAL · 1 day
Promoting the signaling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to... more
Scientists discover new drug target for prostate cancer in the non-coding genome  NEWS MEDICAL · 1 day
Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design. more
Study uncovers how common stomach bacterium maintains its corkscrew-like shape  NEWS MEDICAL · 1 day
A new study shows how a common stomach bacterium is able to keep its corkscrew-like shape as it grows. Disrupting the shape could point the way for future,... more
Tiny organs grown from snake glands produce real venom  Science Magazine · 1 day
Organoids could help develop treatments for snake bites and drugs for human diseases more
Snake stem cells used to create venom-producing organoids  PHYS.ORG · 1 day
Organoids have become an important tool for studying many disease processes and testing potential drugs. Now, they are being used in a surprising and unexpected way: for the production of snake venom.... more
Printing objects that can incorporate living organisms (w/video)  nanowerk · 1 day
A 3D printing system that controls the behavior of live bacteria could someday enable medical devices with therapeutic agents built in. more
Tuning of Optical absorbance of graphene quantum dots by high magnetic fields  nanowerk · 1 day
Scientists report the synthesis of graphene quantum dots under an external high magnetic field and their applications in photothermal therapy. more
New cages to trap molecules push boundaries of protein design  PHYS.ORG · 1 day
Protein design is a popular and rapidly growing field, with scientists engineering novel protein cages—capsule-like nanostructures for purposes such as gene therapy and targeted drug delivery. Many of... more
Is mowing or close grazing of rangelands as beneficial as prescribed burning?  PHYS.ORG · 1 day
When it comes to restoring rangeland habitats, there is no replacement for "prescribed fire," according to Agricultural Research Service (ARS) ecologists. more
Printing objects that can incorporate living organisms  PHYS.ORG · 2 days
A method for printing 3-D objects that can control living organisms in predictable ways has been developed by an interdisciplinary team of researchers at MIT and elsewhere. The technique may lead to 3-D printing... more
Arginine depletion could form the basis for potential rheumatoid arthritis therapies  NEWS MEDICAL · 2 days
A group from the MedUni Vienna has identified a role for the endogenous amino acid arginine in the growth of osteoclasts in rheumatoid arthritis. more
Ex-pharmaceutical exec to be sentenced for pushing opioid  ABC NEWS · 2 days
The founder of an Arizona pharmaceutical company is expected to be sentenced in Boston's federal court Thursday for his role in a bribery and kickback scheme that prosecutors said helped fuel the... more
Carterra closes financing round for continued growth of the LSA platform for next generation antibody discovery  NEWS MEDICAL · 2 days
Carterra Inc., the world leader in high-throughput antibody screening and characterization, has closed a $6M round... more
Synthego adopts GMP standards for producing sgRNA  NEWS MEDICAL · 2 days
Synthego has adopted Good Manufacturing Practice standards for producing customized GMP-grade synthetic guide RNA at its facilities, an initiative the company said will benefit its academic and industry customers as they develop advanced cell... more
Nicoya raises $10 million in series a funding to make drug discovery digital  NEWS MEDICAL · 2 days
Nicoya, a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries, announced today that it has raised $10 million... more
Printing objects that can incorporate living organisms  MIT · 2 days
A 3D printing system that controls the behavior of live bacteria could someday enable medical devices with therapeutic agents built in. more
Controlled-release opioids may lead to endocarditis in injection drug users  NEWS MEDICAL · 2 days
A new study from ICES, Lawson Health Research Institute and Western University suggests that injection drug users prescribed controlled-release hydromorphone are three times more likely to develop endocarditis,... more
Catnip: What do we know about the feline drug?  MNT · 2 days
Catnip is the most famous stimulant for cats. How does it work, why does it not affect all cats, and are there any catnip alternatives? We investigate. more
Scientists reverse HIV latency, take major scientific step toward curative therapies  NEWS MEDICAL · 2 days
Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which... more
Researcher wins $2.5 million grant to study why therapeutic horseback riding benefits autistic children  NEWS MEDICAL · 2 days
After showing that a 10-week therapeutic horseback riding intervention reduced irritability and hyperactivity while improving the social communication skills of... more
Aging of urine fertilizer prevents transfer of antibiotic resistance  NEWS MEDICAL · 2 days
The use of human urine as fertilizer is an important step towards sustainable agriculture because the starting reagent is free, plentiful and useless in most other contexts. It has been... more
Drug combo reverses arthritis in rats  SCIENCE DAILY · 2 days
Researchers have discovered that a powerful combination of 2 experimental drugs reverses the cellular and molecular signs of osteoarthritis in rats as well as in isolated human cartilage cells. more
Ex-pharma CEO gets over 2 years in prison for bribery scheme  ABC NEWS · 2 days
The former head of a drug company has been sentenced to two and a half years in federal prison in a bribery scheme that prosecutors say... more
Surprise discovery shakes up our understanding of gene expression  SCIENCE DAILY · 2 days
A group of scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest... more
Melting reveals drug targets in a living organism  SCIENCE DAILY · 2 days
Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team has developed a technology to systematically identify drug... more
Collaboration reveals promising therapeutic strategy for osteoarthritis  NEWS MEDICAL · 2 days
Osteoarthritis affects 240 million people worldwide and is one of the most common causes of disability in both humans and animals. more
'Lay counselors' help reduce trauma-related symptoms among children orphaned in Africa  NEWS MEDICAL · 2 days
A first-of-its-kind clinical trial involving more than 600 children in Kenya and Tanzania, in which community members were trained to deliver mental health treatment, showed improvement... more
Cancer: Faster drug discovery to hit 'undruggable' targets  SCIENCE DAILY · 2 days
Medicines made from coiled protein fragments could provide a new handle on hard-to-treat diseases like cancer, but they are difficult to design. But a new technique could change that. more
Determining the atomic structure of natural products more rapidly and accurately  SCIENCE DAILY · 2 days
Many drugs are derived from natural products. But before natural products can be exploited, chemists must first determine their structure and stereochemistry. This can be a... more
Researchers reverse HIV latency, important scientific step toward cure  SCIENCE DAILY · 2 days
Overcoming HIV latency -- induction of HIV in CD4+ T cells that lay dormant throughout the body - is a major step toward creating a cure for HIV. For the... more
Finding opens door to early identification of individuals at risk for delirium complications  NEWS MEDICAL · 2 days
Regenstrief Institute and Indiana University School of Medicine researchers have identified blood-based biomarkers associated with both delirium duration and severity in critically... more
UTHSC College of Pharmacy, Kroger Health partner to improve shingles vaccination completion rates  NEWS MEDICAL · 2 days
The College of Pharmacy at the University of Tennessee Health Science Center has partnered with Kroger Health, the healthcare arm of The... more
Animal simulations facilitate smart drug design through prediction of nanomaterial transport to individual tissue cells  Science Magazine · 2 days
Smart drug design for antibody and nanomaterial-based therapies allows optimization of drug efficacy and more efficient early-stage preclinical... more
[Editors' Choice] Angling for a bug-inspired method of coating therapeutics onto microneedles  Science Magazine · 2 days
Mimicking the microstructures on the surface of European true bugs may help optimize loading of therapeutics onto transdermal microneedle patches. more
[Research Articles] PI4KIII{beta} is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma  Science Magazine · 2 days
Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet, the molecular underpinnings and therapeutic implications of this feature remain unclear.... more
Medical News Today: Catnip: What do we know about the feline drug?  MNT · 2 days
Catnip is the most famous stimulant for cats. How does it work, why does it not affect all cats, and are there any catnip... more
Study sheds light on consequences of widespread practice of ringing the cancer bell  NEWS MEDICAL · 2 days
It's a scene that some cancer patients dream about: they celebrate the end of a course of radiation or chemotherapy by ringing... more
Scientists isolate biomarkers that can identify delirium risk and severity  SCIENCE DAILY · 2 days
Researchers have identified blood-based biomarkers associated with both delirium duration and severity in critically ill patients. This finding opens the door to easy, early identification of individuals at... more
Cognitive function in people with mental illness  SCIENCE DAILY · 2 days
A study has shown few differences in the profiles of genes that influence cognition between people with schizophrenia, bipolar disorder and the general population. This surprising finding could provide new insights into therapies designed... more
Researchers slash pre-drug screening time from years to days  PHYS.ORG · 2 days
Researchers at Ben-Gurion University of the Negev (BGU) and The Hebrew University of Jerusalem (HU) have developed a powerful tool that will streamline and accelerate the development of disease therapies,... more
Fighting microbes with microbes  PHYS.ORG · 2 days
The intestinal commensal microbial community (or microbiota) is composed of several microorganisms that, among other functions, are beneficial for the protection against infectious agents. When the microbiota is altered many bacteria are lost, compromising the protective ability and enabling invasion... more
Pilot study highlights the effect of chemotherapy on male fertility  NEWS MEDICAL · 2 days
A pilot study conducted by INRS researchers highlights the effect of chemotherapy on male fertility before and after puberty. more
New findings can help develop more effective antibiotic treatments to fight superbugs  NEWS MEDICAL · 2 days
Researchers have found how an antibiotic used to treat a debilitating gut infection stays put inside the body giving it time to effectively treat... more
Determining the atomic structure of natural products more rapidly and accurately  PHYS.ORG · 2 days
Many drugs are derived from natural products. But before natural products can be exploited, chemists must first determine their structure and stereochemistry. This can be a... more
New X-ray method has 'profound implications' for the development of lifesaving drugs  PHYS.ORG · 2 days
Proteins that contain metal, known as metalloproteins, play important roles in biology, regulating various pathways in the body, which often become targets for lifesaving... more
Melting reveals drug targets in a living organism  PHYS.ORG · 2 days
Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology... more
Research paves the way to improved treatment for complex blood disorders  NEWS MEDICAL · 2 days
Nearly 1.6 billion people worldwide suffer from anemia, and for the first time new research points to how resistance emerges to the drug dexamethasone used to... more
New approach for the manufacture of Advanced Therapy Medicinal Products  NEWS MEDICAL · 3 days
Akron Biotechnology has proposed a new approach for the qualification of ancillary materials for the manufacture of Advanced Therapy Medicinal Products. more
Novel software tool extracts important chemical exposure data  PHYS.ORG · 3 days
Southwest Research Institute is introducing Floodlight, a novel software tool that efficiently discovers the vast numbers of chemical components—previously known and unknown—present in the food, air, drugs and products we are exposed... more
Urine fertilizer: 'Aging' effectively protects against transfer of antibiotic resistance  PHYS.ORG · 3 days
Recycled and aged human urine can be used as a fertilizer with low risks of transferring antibiotic resistant DNA to the environment, according to new research from the... more
Pain management program uses new approach to reduce narcotic prescriptions after surgery  NEWS MEDICAL · 3 days
Surgeons at Houston Methodist Hospital are stemming the tide of addiction to prescription opioids by managing patients' pain after surgery. more
Study: A majority of US physicians receive marketing payments for stimulant medications  NEWS MEDICAL · 3 days
Results of a new study show that a large number of physicians in the US may have received marketing payments from pharmaceutical companies that... more
Partnership between medical specialties helps improve cardiovascular health  NEWS MEDICAL · 3 days
Starting in 2016, a two-year partnership between the North Carolina Chapter of the American College of Cardiology (NCACC) and the North Carolina Association of Free and Charitable Clinics (NCAFCC) provided free lipid... more
New method determines the atomic structure of natural products more rapidly, accurately  NEWS MEDICAL · 3 days
Many drugs are derived from natural products. But before natural products can be exploited, chemists must first determine their structure and stereochemistry. more
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