Since the discovery of insulin nearly 100 years ago, scientists have explored how it interacts with its receptor with the goal of improving the ability of therapeutic insulins to mimic the way insulin works in the body.... NEWS MEDICAL · 4 weeks
Requirement for translocon-associated protein (TRAP) {alpha} in insulin biogenesis  Science Magazine · 6 days
The mechanistic basis for the biogenesis of peptide hormones and growth factors is poorly understood. Here, we show that the conserved endoplasmic reticulum membrane translocon-associated protein ╬▒ (TRAP╬▒), also known... more
WHO announces two-year scheme to drive down the price of insulin  NEWS MEDICAL · 3 weeks
The World Health Organization plans to make insulin more affordable for the millions of people suffering from diabetes. more
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New research suggests that low-calorie sweeteners cause only modest changes in blood sugar, insulin levels, insulin sensitivity and weight gain, as compared to those induced by... more
Early-morning, starch-rich meal improves glycemic control among type 2 diabetics  NEWS MEDICAL · 1 week
Type 2 diabetics inject themselves with insulin, a hormone that regulates the movement of sugar into liver, muscle and fat cells, up to four times a day. But... more
New way to promote insulin production in pre-diabetes phase discovered  NEWS MEDICAL · 4 weeks
Nanyang Technological University, Singapore scientists have discovered that a type of immune cell known as 'pancreatic islet macrophages' is capable of promoting insulin production during the pre-diabetes phase. more
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The dopamine D2 receptor has a previously unobserved role in modulating Wnt expression and control of cell proliferation, according to a new study from the George Washington University and the... more
Researchers uncover the binding mechanism of opioid receptor  NEWS MEDICAL · 2 weeks
Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor. more
Elucidating the active {delta}-opioid receptor crystal structure with peptide and small-molecule agonists  Science Magazine · 2 weeks
Selective activation of the -opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover,... more
West Virginians head to Canada to find affordable insulin  ABC NEWS · 2 days
A group of West Virginians have gone to Canada to find affordable insulin more
Insulin can increase mosquitoes' immunity to West Nile virus  SCIENCE DAILY · 4 weeks
A discovery has the potential to inhibit the spread of West Nile virus as well as Zika and dengue viruses. The researchers demonstrated that mammalian insulin activated an antiviral immunity... more
Eating in sync with biological clock could replace problematic diabetes treatment  SCIENCE DAILY · 1 week
A new study finds that a starch-rich breakfast consumed early in the morning coupled with a small dinner could replace insulin injections and other diabetes medications... more
When solids and liquids meet: In nanoscale detail  PHYS.ORG · 1 week
How a liquid interacts with the surface of a solid is important in batteries and fuel cells, chemical production, corrosion phenomena, and many biological processes. more
Study shows insulin can increase mosquitoes' immunity to West Nile virus  PHYS.ORG · 4 weeks
A discovery by a Washington State University-led research team has the potential to inhibit the spread of West Nile virus as well as Zika and dengue... more
Cell factors decide if a cancer grows or dies, says new study  NEWS MEDICAL · 3 weeks
A new study published today in the journal Cell Reports by scientists at the German Cancer Research Center (DKFZ) shows that the direction taken... more
Virome analysis reveals clues for increased risk of type 1 diabetes in children  NEWS MEDICAL · 1 week
New results from The Environmental Determinants of Diabetes in the Young study show an association between prolonged enterovirus infection and the development... more
Research unravels mystery of how early animals survived ice age  PHYS.ORG · 1 week
How did life survive the most severe ice age? A McGill University-led research team has found the first direct evidence that glacial meltwater provided a crucial lifeline to... more
Nanoscale exploration of the solid-liquid interface  nanowerk · 1 week
How a liquid interacts with the surface of a solid is important in batteries and fuel cells, chemical production, corrosion phenomena, and many biological processes. more
Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling  Science Magazine · 4 weeks
The genetic bases for most human sleep disorders and for variation in human sleep quantity and quality are largely unknown. Using the zebrafish, a diurnal vertebrate,... more
New laser technique images quantum world in a trillionth of a second  SCIENCE DAILY · 13 hours
For the first time, researchers have been able to record, frame-by-frame, how an electron interacts with certain atomic vibrations in a solid. The technique... more
New laser technique images quantum world in a trillionth of a second  PHYS.ORG · 14 hours
For the first time, researchers have been able to record, frame-by-frame, how an electron interacts with certain atomic vibrations in a solid. The technique... more
New role for dopamine in gene transcription and cell proliferation  SCIENCE DAILY · 4 weeks
The dopamine D2 receptor has a previously unobserved role in modulating Wnt expression and control of cell proliferation, according to a new study. The research could have implications... more
New water-based optical device revolutionizes the field of optics research  PHYS.ORG · 3 weeks
Light is versatile in nature. In other words, it shows different characteristics when traveling through different types of materials. This property has been explored with various technologies, but... more
Brain receptor that regulates body temperature may also be the key to rapid weight loss  NEWS MEDICAL · 1 week
The brain mechanism that enables us to maintain a constant body temperature may also be the key to... more
Diabetes curriculum may help empower students to make healthy choices  NEWS MEDICAL · 2 weeks
For Lola McPherren, learning about diabetes is personal. The Juanita High School ninth-grader had a grandfather with diabetes. She recalled that he gave himself a shot of insulin... more
Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy  NEWS MEDICAL · 1 day
A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with mantle cell lymphoma resistant to prior... more
Fast-acting autoantibodies muscle in on encephalitis  Science Magazine · 4 days
Autoantibodies that recognize the glycine receptor mediate pathology by directly interrupting glycinergic neurotransmission that manifests as a disorder characterized by muscle stiffness and spasms. more
Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug  NEWS MEDICAL · 3 weeks
The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+)... more
Modeling other minds: Bayesian inference explains human choices in group decision-making  Science Magazine · 2 weeks
To make decisions in a social context, humans have to predict the behavior of others, an ability that is thought to rely on having a model... more
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