The emergence of superresolution (SR) fluorescence microscopy has rejuvenated the search for new cellular sub-structures and dynamic intermediates. However, limited by the broad emission spectrum of fluorophores and excessive phototoxicity, SR fluorescence microscopy can only be used to highlight a handful of biomolecules simultaneously and is incapable of providing a holistic map of the cellular environment and landscape.... PHYS.ORG · 1 month
[Editors' Choice] Beyond synuclein: Organelle accumulation in Lewy bodies may drive neurodegeneration  Science Magazine · 3 days
Organelle sequestration in Lewy bodies correlates more closely with neurodegeneration than α-synuclein aggregation alone. more
Newly identified cellular trash removal program helps create new neurons  SCIENCE DAILY · 4 weeks
New research reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons. more
Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination-mediated DNA repair  Science Magazine · 2 weeks
Previously, we reported that chromodomain Y–like (CDYL) acts as a crotonyl–coenzyme A hydratase and negatively regulates histone crotonylation (Kcr). However, the global CDYL-regulated crotonylome remains unclear.... more
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In cellular biology, mistakes can be good  PHYS.ORG · 2 days
Mistakes are rarely rewarded. Intuitively, one would imagine that a shoddy typist at an office who keeps generating typos would either quickly lose their job, or at least be overlooked for promotion. The idea... more
[Editors' Choice] "You are what you eat!"  Science Magazine · 2 weeks
Single-cell transcriptomic analysis reveals how caloric restriction prevents aging at the cellular level. more
Study shows how cellular filament helps neural stem cells clear damaged, clumped proteins  NEWS MEDICAL · 4 weeks
New research by University of Wisconsin-Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an... more
Pervasive functional translation of noncanonical human open reading frames  Science Magazine · 3 weeks
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As the ice sheet covering most of Greenland retreats, Florida State University researchers are studying the newly revealed landscape to understand its role in... more
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A team have established a method of fully autonomous scanning probe microscopy (SPM) controlled by artificial intelligence. more
A pigment from ancient Egypt to modern microscopy  SCIENCE DAILY · 1 week
Egyptian blue is one of the oldest humanmade colour pigments. It adorns the crown of the world famous bust of Nefertiti: but the pigment can do even more. An international research team... more
Wildfire perceptions largely positive after hiking in a burned landscape  PHYS.ORG · 2 days
When hikers returned to UC Davis Stebbins Cold Canyon Reserve in 2016, a year after a wildfire swept through its expanse of oak trees and chaparral in Northern... more
New technology could enable more accessible form of electron cryo-microscopy  NEWS MEDICAL · 2 weeks
The Rosalind Franklin Institute has committed to developing a multi-million pound technology which enables a more accessible form of electron cryo-microscopy. more
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The current COVID-19 pandemic is rapidly changing the way we live and the way we work. Do these changes signal long-lasting impacts on the... more
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2  Science Magazine · 2 days
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing the serious coronavirus disease... more
Neanderthals were pioneers in marine resource exploitation: study  PHYS.ORG · 2 days
The journal Science has published a study led by the ICREA researcher João Zilhão from the University of Barcelona on the excavation in Cueva de Figueira Brava, Portugal, which was used as... more
Single-drug therapy can attack several cellular targets using different modes of action  NEWS MEDICAL · 2 weeks
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Biology researchers capture shape-shifting delivery structures in body's 'cellular FedEx system'  PHYS.ORG · 3 weeks
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How caloric restriction prevents negative effects of aging in cells  SCIENCE DAILY · 1 month
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A new laboratory method allows researchers to create compartments within a liquid that, like drops of oil in water, are separate but have no physical barrier... more
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies  Science Magazine · 3 weeks
The regulation of messenger RNA levels in mammalian cells can be achieved by the modulation of synthesis and degradation rates. Metabolic RNA-labeling experiments in bulk have... more
Systems-level investigation of aqueous batteries for understanding the benefit of water-in-salt electrolyte by synchrotron nanoimaging  Science Magazine · 3 weeks
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AI helps reveal apparent cellular distinctions between black and white cancer patients  NEWS MEDICAL · 3 weeks
Scientists at Case Western Reserve University are using Artificial Intelligence (AI) to reveal apparent cellular distinctions between black and white cancer patients, while also... more
In silico experiments of bone remodeling explore metabolic diseases and their drug treatment  Science Magazine · 3 weeks
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Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage  Science Magazine · 2 weeks
Aging or injury leads to degradation of the cartilage matrix and the development of osteoarthritis (OA). Because of a paucity of single-cell... more
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