The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding t... Science Magazine · 3 months
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NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages  Science Magazine · 1 week
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Understanding the risk factors of cognitive decline are now more important than ever. A recent study examined the potential role of inflammation. more
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