Scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration that is seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.  The discovery was so novel, the scientists needed to coin a new term to describe it: mitoautophagy, a collection of self-destructive mitochondria in diseased upper motor neurons of the brain that begin to disintegrate from within at a very early age.... SCIENCE DAILY · 2 weeks
Self-destructive mitochondria may set the stage for neurodegeneration in ALS  NEWS MEDICAL · 16 hours
Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration seen in diseases such as ALS, which... more
N Ireland laws on abortion, same-sex marriage, set to change  PHYS.ORG · 4 weeks
Northern Ireland is set to decriminalize abortion and set the stage for legalization of same-sex marriages as of midnight Monday, bringing its laws in line with the rest... more
Seeking better treatment for ALS, Lou Gehrig's disease  SCIENCE DAILY · 3 weeks
In neurodegenerative disease ALS, proteins called TDP-43 aggregate in patient tissues. A team led by researchers at Cold Spring Harbor Laboratory found that in ALS, TDP-43 proteins are dysfunctional, causing de-silencing of... more
Newly discovered protein is the permit to the powerhouse of cells  SCIENCE DAILY · 4 weeks
Researchers report the discovery of a protein, P17/PERMIT, that is key to recycling aging and damaged mitochondria. Defective mitochondria are characteristic of a number of age-related... more
How cells protect themselves from mitochondrial defects  PHYS.ORG · 4 weeks
Cells need powerhouses known as mitochondria to utilize the energy stored in our food. Most of the proteins required for this powerhouse function are encoded in the nucleus and transported into the mitochondria after... more
Oxygen deficiency rewires mitochondria  SCIENCE DAILY · 1 week
Mitochondria burn oxygen and provide energy for the body. Cells lacking oxygen or nutrients have to change their energy supply quickly in order to keep growing. Scientists have now shown that mitochondria are reprogrammed under depleted oxygen and nutrients. Tumors... more
Oxygen deficiency rewires mitochondria  PHYS.ORG · 2 weeks
Mitochondria burn oxygen and provide energy for the body. Cells lacking oxygen or nutrients have to change their energy supply quickly in order to keep growing. Scientists from the Max Planck Institute for Biology of Ageing have now shown that... more
TDP-43 study could speed up the diagnosis and treatment of ALS  NEWS MEDICAL · 3 weeks
A new study suggests that TDP-43 may be used as a biomarker in the diagnosis and treatment of amyotrophic lateral sclerosis (ALS). more
Chemotherapy sometimes set the stage for drug-resistant leukemia at relapse  SCIENCE DAILY · 2 weeks
An international collaboration has identified therapy-induced, drug-resistance mutations in children with acute lymphoblastic leukemia who relapse. more
Exceptional fossils may need a breath of air to form  SCIENCE DAILY · 2 weeks
New research has found that a long held belief by paleontologists about the fossilization process may be wrong. The team has found that while low oxygen environments set... more
Mitocellular communication: Shaping health and disease  Science Magazine · 5 days
Throughout the animal kingdom, mitochondria are the only organelles that retain their own genome and the transcription and translation machineries that are all essential for energy harvesting. Mitochondria have developed a complex communication network, allowing them... more
The shelf life of pyrite  SCIENCE DAILY · 4 weeks
What exactly triggers the increase in carbon dioxide concentrations that causes the transition from a glacial stage to a warm stage is not fully understood. Scientists have developed a new model in which the weathering of pyrite, a... more
In vitro culture of cynomolgus monkey embryos beyond early gastrulation  Science Magazine · 3 weeks
Gastrulation is a key event in embryonic development when the germ layers are specified and the basic animal body plan is established. The complexities of primate gastrulation remain... more
Medical News Today: Late stage breast cancer survival estimate is 'rarely accurate'  MNT · 4 days
Single-number survival estimates for people with late stage breast cancer are unhelpful, research shows. So what approach would be more beneficial? more
Virgin Orbit to add extra rocket stage to LauncherOne for interplanetary missions  SPACE NEWS · 4 weeks
Virgin Orbit, while preparing for the first flight of its LauncherOne smallsat rocket, is in the process of choosing an engine for a three-stage... more
SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy  Science Magazine · 2 weeks
A homozygous mutation of human tyrosyl-DNA phosphodiesterase 1 (TDP1) causes the neurodegenerative syndrome, spinocerebellar ataxia with axonal neuropathy (SCAN1). TDP1 hydrolyzes the phosphodiester bond between DNA 3'-end and... more
Surgery can improve survival rate for oldest patients with early stage lung cancer  NEWS MEDICAL · 49 minutes
Many patients with early stage lung cancer who are age 90 years and older do not receive treatment; however, surgery in this... more
First effective noninvasive method for diagnosing early-stage liver diseases  NEWS MEDICAL · 3 weeks
A safer and more sensitive contrast dye for MRI tests developed by a team led by Georgia State University researchers may provide the first effective, noninvasive method for detecting and... more
The shelf life of pyrite  PHYS.ORG · 4 weeks
The last 2.6 million years are characterized by glacial cycles, a regular alternation of cold and warm periods. It is widely accepted that changes in the concentrations of carbon dioxide and other greenhouse gases in the atmosphere were... more
Cardiac-specific biomarkers may help predict CVD risk factors early  NEWS MEDICAL · 7 days
A new review article provides valuable insights into how traditional and emerging cardiac-specific biomarkers and their associated cardiovascular disease (CVD) risk factors may help point to effective preventive interventions in... more
Earliest stage of hearing loss is linked to cognitive decline  NEWS MEDICAL · 5 days
Research has shown that adults with age-related hearing loss have higher rates of cognitive decline. Now, a study from researchers at Columbia University Vagelos College of Physicians and... more
Mega-infrastructure projects in Africa, Asia and Latin America are reshaping development  PHYS.ORG · 3 weeks
Huge investments in infrastructure are redefining global development, from China's Belt and Road Initiative to infrastructure development plans from the African Development Bank and the Initiative... more
New Research on Giant Radio Galaxies Defies Conventional Wisdom  ASTRO WATCH · 3 weeks
Conventional wisdom tells us that large objects appear smaller as they get farther from us, but this fundamental... more
Q-suite motor assessment tool promising for evaluating Huntington's disease  SCIENCE DAILY · 4 weeks
In clinical trials of adults with Huntington's disease (HD) the Q-Suite Motor Assessment Tool (Q-Motor) has proven to be helpful to detect and quantitate subtle motor abnormalities. With the anticipated... more
N Ireland laws on abortion, same-sex marriage, set to change  ABC NEWS · 4 weeks
Abortion is set to be decriminalized and same-sex marriage legalized in Northern Ireland as of midnight, bringing its laws in line with the rest of the U.K. more
Newly discovered protein is key to recycling aging mitochondria  NEWS MEDICAL · 4 weeks
Aging, and the mechanics behind it, remains one of the most closely guarded secrets of life. more
Master regulator in mitochondria is critical for muscle function and repair  SCIENCE DAILY · 4 days
New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness. more
Study: SDHI pesticides induce oxidative stress and kill human cells  NEWS MEDICAL · 2 weeks
Mitochondria are organelles that are present in eukaryotic cells. They contain respiratory chains that are crucial for the survival of organisms. more
UK aims to lead with cutting-edge radiation therapy  NEWS MEDICAL · 2 weeks
The UK is all set to launch its run into the future as the undisputed leader in the field of personalized and effective radiation therapy. The proposal is undergirded by a whopping... more
New metal–organic framework can take on toxic sulfur dioxide gas  PHYS.ORG · 2 weeks
An international team has developed a robust material that can selectively take in toxic sulfur dioxide gas at record concentrations and preserve it for use in chemical production.... more
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