The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract. However, it can also cause life-threatening infections, especially in immunocompromised patients.... NEWS MEDICAL · 1 week
Fluconazole makes fungi sexually active  SCIENCE DAILY · 1 week
Under the influence of the drug fluconazole, the fungus Candida albicans can change its mode of reproduction and thus become even more resistant, scientists report. more
Scientists uncover new information about development of gastric cancer  NEWS MEDICAL · 3 weeks
Cardiff University researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future. more
Mechanisms of insecticide resistance impact transmission of West Nile virus  NEWS MEDICAL · 3 weeks
In a context of overuse of insecticides, which leads to the selection of resistant mosquitoes, it is already known that this resistance to insecticides affects interactions between mosquitoes... more
Insecticide resistance genes affect vector competence for West Nile virus  SCIENCE DAILY · 3 weeks
In a context of overuse of insecticides, which leads to the selection of resistant mosquitoes, it is already known that this resistance to insecticides affects interactions between mosquitoes... more
Planetary scientists continue to puzzle over the mysterious slope streaks on Mars. What's causing them?  PHYS.ORG · 4 weeks
Since they were first observed in the 1970s by the Viking missions, the slope streaks that periodically appear... more
New drug resistance process found in bacteria  PHYS.ORG · 4 weeks
A team of researchers has discovered a new process capable of generating resistance to synthetic antibacterial drugs within bacterial populations long before they are put to clinical use. more
Antibiotic resistances spread faster than so far thought  PHYS.ORG · 54 minutes
By studying fish raised in aquaculture, researchers from the Helmholtz Zentrum München, the University of Copenhagen and the University of Campinas in Brazil have shed new light on the mechanisms by which... more
New tuberculosis drug may shorten treatment time for patients  SCIENCE DAILY · 7 days
A new experimental antibiotic for tuberculosis has been shown to be more effective against TB than isoniazid, a decades-old drug which is currently one of the standard treatments. In mouse... more
Atomic-scale simulation of antiarrhythmic drug interaction with cardiac cells  PHYS.ORG · 2 weeks
To unravel the mysterious mechanisms of drug potency for the treatment of cardiac arrhythmias, a group of researchers at UC Davis have developed novel simulations that provide insights on vital... more
New simulations offer insights on vital atomic-scale drug-cardiac cells interactions  NEWS MEDICAL · 1 week
To unravel the mysterious mechanisms of drug potency for the treatment of cardiac arrhythmias, a group of researchers at UC Davis have developed novel simulations that provide insights... more
Superconductors: Resistance is Futile  PHYS.ORG · 3 weeks
Every standard cable, every wire, every electronic device has some electric resistance. There are, however, superconducting materials with the ability to conduct electrical current with a resistance of exactly zero – at least at very low temperatures. Finding a material... more
Cancer has a biological clock and this drug may keep it from ticking  SCIENCE DAILY · 4 weeks
Scientists find and test a promising drug that stops cancer by interfering with the cancer cells' metabolism and other circadian-related functions. more
OCTN: A transporter with relevance to human pathophysiology, drug discovery and diagnostics  PHYS.ORG · 3 weeks
In the February 2019 issue of SLAS Discovery, a review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing... more
New insight into cell membranes could improve drug testing and design  PHYS.ORG · 4 weeks
Research at the University of Arkansas on membrane proteins could lead to better development and testing of drugs. Chemistry researchers studied a type of membrane protein... more
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein  Science Magazine · 4 days
ABCB1, also known as P-glycoprotein, actively extrudes xenobiotic compounds across the plasma membrane of diverse cells, which contributes to cellular drug resistance and interferes with therapeutic drug delivery.... more
Drug shows promise to treat diet-induced osteoarthritis  SCIENCE DAILY · 3 weeks
Scientists have found that a drug derived from omega-3 fatty acids can reduce osteoarthritis inflammation that's been caused by a high-fat diet. more
Medical News Today: Simple drug formula regenerates brain cells  MNT · 7 days
Scientists have shown how a drug cocktail of four compounds can convert glia, or support cells, next to damaged neurons into new working neurons. more
Simple drug formula regenerates brain cells  MNT · 7 days
Scientists have shown how a drug cocktail of four compounds can convert glia, or support cells, next to damaged neurons into new working neurons. more
Motor enzyme protects genome through several mechanisms  PHYS.ORG · 1 week
A helicase, Pfh1, can thanks to several different mechanisms protect the genome from DNA obstacles and damages associated with cancer. This is shown in a new doctoral thesis at Umeå University, Sweden. more
Hop to it: Researchers evaluate rabbits' evolved resistance to myxoma virus  SCIENCE DAILY · 4 days
Researchers have validated the role of specific rabbit genes in contributing to this acquired resistance. more
Certifying attack resistance of convolutional neural networks  PHYS.ORG · 3 weeks
When shopping for a watch, you may notice its water resistance rating, which indicates that the watch is warranted to be waterproof to a certain level. What about your neural network? Can one ensure... more
Novel lysin therapy shows promise for fighting drug-resistant bacteria  NEWS MEDICAL · 2 weeks
Humans are in a constant arms race with infectious bacteria. To kill these disease microbes, we develop powerful antibiotics; and in turn, the bacteria develop resistance against these drugs. more
How to create health care centaurs, half doctors and half managers  SCIENCE DAILY · 3 weeks
If hospital doctors around the world often struggle to become those health centaurs, half professionals and half managers, that modern healthcare organizations need, the main responsibility... more
Fluconazole makes fungi sexually active  PHYS.ORG · 1 week
The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract. However, it can also cause life-threatening infections, especially in immunocompromised patients. more
Waterproof graphene electronic circuits  nanowerk · 3 weeks
Water molecules distort the electrical resistance of graphene, but a team of researchers has discovered that when this two-dimensional material is integrated with the metal of a circuit, contact resistance is not impaired by humidity. more
Science News » Mega Docking Library Poised to Speed Drug Discovery  NIMH · 2 weeks
Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the... more
Open-science model for drug discovery expands to neurodegenerative diseases  SCIENCE DAILY · 3 days
Parkinson's disease and Amyotrophic Lateral Sclerosis are the newest frontiers for open science drug discovery, a global movement led by academic scientists that puts knowledge sharing and medication affordability ahead... more
Scientists uncover mechanism that makes aspergillus infection fatal  NEWS MEDICAL · 7 days
Researchers at the University of Jena in Germany have discovered how Aspergillus fumigatus suppresses immune defences to enable the infection to become fatal. more
A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila  Science Magazine · 3 weeks
Sleep remains a major mystery of biology. In particular, little is known about the mechanisms that account for the drive to sleep. In an unbiased screen... more
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