Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development. The findings may lay the groundwork for future treatments for the highly complex neuropsychiatric disorder.... SCIENCE DAILY · 6 days
A gene that acts as master regulator of schizophrenia identified  NEWS MEDICAL · 6 days
Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of... more
Scientists discover major regulator of schizophrenia that is active during early development  NEWS MEDICAL · 5 days
Researchers have discovered a gene that acts as a master regulator of schizophrenia during the early stages of human brain development. more
Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia  Science Magazine · 6 days
Applying tissue-specific deconvolution of transcriptional networks to identify their master regulators (MRs) in neuropsychiatric disorders has been largely unexplored. Here, using two schizophrenia (SCZ)... more
Scientists identify specific gene that plays key role in several psychiatric conditions  NEWS MEDICAL · 4 weeks
Scientists have identified a specific gene they believe could be a key player in the changes in brain structure seen in several psychiatric conditions,... more
The neurobiological mechanisms behind schizophrenia may depend on gender  SCIENCE DAILY · 2 weeks
The neurobiological pathophysiology of schizophrenia differs significantly between males and females, according to a new study. The findings suggest a possible need for more sex-specific treatments for schizophrenia. The study... more
Getting to the root of how plants tolerate too much iron  SCIENCE DAILY · 3 weeks
Scientists have found a major genetic regulator of iron tolerance, a gene called GSNOR. The findings could lead to the development of crop species that produce... more
UC San Francisco scientists identify second 'short sleep' gene after 10-year search  NEWS MEDICAL · 3 weeks
After a decade of searching, the UC San Francisco scientists who identified the only human gene known to promote "natural short sleep" -- lifelong,... more
Analysis of global cancer data shines light on alternative gen 'switches' in tumors  PHYS.ORG · 2 weeks
Scientists from the Agency for Science, Technology and Research (A*STAR)'s Genome Institute of Singapore (GIS) have discovered that many human cancers exhibit... more
Regulator of first responder cells to brain injury  SCIENCE DAILY · 1 week
Researchers identified nuclear factor I-A (NFIA) as a central regulator of both the generation and activity of reactive astrocytes. more
'Key player' identified in genetic link to psychiatric conditions  SCIENCE DAILY · 4 weeks
Scientists have identified a specific gene they believe could be a key player in the changes in brain structure seen in several psychiatric conditions, such as schizophrenia and autism. more
[Editors' Choice] Alternative rhythms in schizophrenia  Science Magazine · 4 weeks
A distinct set of rhythmically expressed genes related to mitochondrial function is identified in the brains of patients with schizophrenia. more
Signal blocks stem cell division in geriatric brain  SCIENCE DAILY · 3 weeks
Scientists have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether... more
Preventing the onset of schizophrenia in mouse model  SCIENCE DAILY · 1 week
Although predisposing processes occur earlier, schizophrenia breaks out at young adulthood, suggesting it might involve a pathological transition during late brain development in predisposed individuals. Using a genetic mouse model of schizophrenia,... more
Researchers investigate how to prevent the onset of schizophrenia using mouse model  NEWS MEDICAL · 1 week
Although predisposing processes occur earlier, schizophrenia breaks out at young adulthood, suggesting it might involve a pathological transition during late brain development in predisposed... more
New lipid signaling target may improve T cell immunotherapy  SCIENCE DAILY · 4 weeks
T cell immunotherapy uses the immune system to kill cancer cells. To increase the efficacy of this new treatment, researchers aimed to discover a master regulator of T cell fate.... more
Dietary supplement may help with schizophrenia  SCIENCE DAILY · 1 week
A dietary supplement, sarcosine, may help with schizophrenia as part of a holistic approach complementing antipsychotic medication, according to a researcher. more
Researchers Create Albino Lizards Using CRISPR-Cas9 Gene Editing  SCI-NEWS.COM · 2 weeks
A team of scientists at the University of Georgia has used CRISPR-Cas9 gene editing to engineer brown anoles (Anolis sagrei)... more
Biological 'rosetta stone' brings scientists closer to deciphering how the body is built  SCIENCE DAILY · 3 weeks
Every animal contains in their genome pieces of DNA called Hox genes. Architects of the body, these genes are keepers of the... more
Neurobiological pathophysiology of schizophrenia differs based on gender  NEWS MEDICAL · 2 weeks
The neurobiological pathophysiology of schizophrenia differs significantly between males and females, according to a new study. more
Risk for schizophrenia and bipolar disorder has distinct effects on the brain  NEWS MEDICAL · 4 weeks
Brain abnormalities in people at familial risk of schizophrenia and bipolar disorder emerge in unique patterns, despite the symptom and genetic overlap of the... more
Scientists sharpen gene editing tool  PHYS.ORG · 4 days
Wake Forest Institute for Regenerative Medicine scientists have fine-tuned their delivery system to deliver a DNA editing tool to alter DNA sequences and modify gene function. The improved "hit and run" system works faster and is more efficient. more
Scientists identify how nature builds with chitin  NEWS MEDICAL · 3 weeks
Writers know the power of the pen, but scientists are just discovering its secrets. more
Scientists develop technique to reveal epigenetic features of cells in the brain  SCIENCE DAILY · 1 week
Researchers combined two different analysis techniques into one method, to simultaneously analyze how chromosomes, along with their epigenetic features, are compacted inside of single... more
Scientists discover brain areas for understanding metaphors in healthy and schizophrenic people  NEWS MEDICAL · 1 week
Scientists have used MRI scanners to discover the parts of the brain which understand metaphors, in both healthy volunteers and people with schizophrenia. more
Many psychiatric disorders have heightened impulsivity  SCIENCE DAILY · 3 weeks
The study analyzed data from studies across eight different psychiatric disorders, including major depressive disorder, bipolar disorder, borderline personality disorder, schizophrenia, eating disorders, and others. The largest delay discounting effects were found to be associated with... more
A new path to cancer therapy: developing simultaneous multiplexed gene editing technology  SCIENCE DAILY · 4 weeks
Scientists have developed a new gene editing system that could be used for anticancer immunotherapy through the simultaneous suppression of proteins that interfere with... more
Risk of psychotic disorders has disease-specific brain effects  SCIENCE DAILY · 4 weeks
Brain abnormalities in people at familial risk of schizophrenia and bipolar disorder emerge in unique patterns, despite the symptom and genetic overlap of the disorders, according to a new study. Similarities between... more
SATI gene editing could replace CRISPR  NEWS MEDICAL · 2 weeks
Scientists have developed a new gene editing tool called SATI that is safer than CRISPR. more
Gene editing tool gets sharpened by WFIRM team  SCIENCE DAILY · 4 days
Scientists have fine-tuned their delivery system to deliver a DNA editing tool to alter DNA sequences and modify gene function. The improved 'hit and run' system works faster and is more efficient. more
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