While it has long been recognized that mutated gene NPM1 plays an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function.... NEWS MEDICAL · 4 weeks
Potential seen for tailoring treatment for acute myeloid leukemia  SCIENCE DAILY · 3 days
Rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia. Research on the differing drug response patterns of leukemia... more
FDA approves new combination therapy for acute myeloid leukemia  NEWS MEDICAL · 2 weeks
Older patients with acute myeloid leukemia (AML) often aren't healthy enough to receive intensive chemotherapy, and gentler treatments aren't very effective in treating this aggressive blood cancer. more
Researchers identify powerful inhibitor of epigenetic factors that promote acute myeloid leukemia  NEWS MEDICAL · 2 weeks
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers... more
Cancer stem cells get energy from protein, and it's proving to be their Achilles' heel  SCIENCE DAILY · 4 weeks
A new study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Clinical trial based... more
Researchers identify inconspicuous protein as key to aggressive blood cancer  NEWS MEDICAL · 2 weeks
Five percent of acute leukemia cases are diagnosed as mixed lineage leukemia. MLL is an aggressive blood cancer that predominantly occurs in infants and has been difficult to... more
Discovery of selective chemical probes that inhibit epigenetic factors for acute myeloid leukemia  PHYS.ORG · 3 weeks
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration,... more
Research advances offer hope for patient-tailored AML treatment  NEWS MEDICAL · 1 day
Advances in rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia. more
FDA approves new treatment for AML patients  NEWS MEDICAL · 3 weeks
The U.S. Food and Drug Administration today approved Daurismo (glasdegib) tablets to be used in combination with low-dose cytarabine (LDAC), a type of chemotherapy, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in... more
LZTR1 is a regulator of RAS ubiquitination and signaling  Science Magazine · 4 weeks
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper like transcription regulator 1 (LZTR1) gene led... more
Researchers unraveling the mystery of how sperm cells navigate  PHYS.ORG · 4 weeks
Researchers have found that a protein in the cell membranes of sperm plays a key role in how they find their way to eggs. The PMCA protein may also help... more
Newly diagnosed AML in older adults: Results for venetoclax  SCIENCE DAILY · 2 weeks
Clinical trial results show a 91 percent response rate to the combination of venetoclax with azacitidine in older adults newly diagnosed with acute myeloid leukemia (AML). Of 33 patients given... more
Using molecular targeting approach to kill melanoma cells  NEWS MEDICAL · 2 weeks
In 1960, scientists described the "Philadelphia chromosome" that causes chronic myeloid leukemia, and in 2001 the Food and Drug Administration approved the drug imatinib to disable the action of this cancer-causing genetic... more
[Research Articles] Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells  Science Magazine · 2 weeks
Allogeneic hematopoietic cell transplantation (allo-HCT) not only is an effective treatment for several hematologic malignancies but can also result in... more
Researchers succeed in building protein nanotubes from tiny scaffolds  NEWS MEDICAL · 4 weeks
Researchers at Tokyo Institute of Technology have succeeded in constructing protein nanotubes from tiny scaffolds made by cross-linking of engineered protein crystals. more
How does potassium enter cells?  SCIENCE DAILY · 2 weeks
For decades it was assumed that protein channels and protein pumps fulfilled completely different functions and worked independently of each other. Researchers have now elucidated the transport path of a protein complex that combines both mechanisms: it first... more
Honeybee protein keeps stem cells youthful  PHYS.ORG · 6 days
An active protein component of royal jelly helps honeybees create new queens. Stanford researchers have identified a similar protein in mammals, which keeps cultured embryonic stem cells pluripotent. more
NIH researchers shed light on causes of HBV-associated acute liver failure  NEWS MEDICAL · 4 weeks
National Institutes of Health scientists and their collaborators found that hepatitis B virus-associated acute liver failure--a rare condition that can turn fatal within days without liver... more
New method could improve outcome of leukemia patients receiving stem-cell transplants  NEWS MEDICAL · 2 weeks
Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients'... more
New research on stem cell transplantation for myeloid cancers  SCIENCE DAILY · 1 week
Improving outcomes for patients with myeloid cancers who undergo stem cell transplantation is a focus of several studies being presented this week. more
How does potassium enter cells?  PHYS.ORG · 2 weeks
For decades, it was assumed that protein channels and protein pumps fulfilled completely different functions and worked independently of each other. Researchers at Goethe University Frankfurt and University Groningen have now elucidated the transport path of a protein... more
Scientists solve longtime mystery in innate immunity  SCIENCE DAILY · 2 weeks
Scientists have long wondered how one protein, NLRP3, can promote inflammation in response to a wide range of seemingly unrelated stimuli. more
Nanotubes built from protein crystals: Breakthrough in biomolecular engineering  SCIENCE DAILY · 4 weeks
Researchers at Tokyo Tech have succeeded in constructing protein nanotubes from tiny scaffolds made by cross-linking of engineered protein crystals. The achievement could accelerate the development of artificial enzymes, nano-sized... more
Nanotubes built from protein crystals: Breakthrough in biomolecular engineering  PHYS.ORG · 4 weeks
Researchers at Tokyo Institute of Technology (Tokyo Tech) have constructed protein nanotubes from tiny scaffolds made by cross-linking of engineered protein crystals. The achievement could accelerate the development of artificial... more
The protein with the starting gun  PHYS.ORG · 2 weeks
Whether dormant bacteria begin to reproduce is no accidence. Rather, they are simply waiting for a clear signal from a single protein in the cell interior. ETH researchers have now deciphered the molecular mechanisms behind this. more
How Much Protein Do You Really Need?  NPR · 1 week
Protein snacks and supplements are popular, but unless you're an extreme athlete or recovering from an injury, you may already get enough protein in your diet. Here's how to tell how much you need. more
Pulsed radiofrequency relieves acute back pain and sciatica  SCIENCE DAILY · 2 weeks
A minimally invasive procedure in which pulses of energy from a probe are applied directly to nerve roots near the spine is safe and effective in people with acute lower back pain... more
Pulling the genome apart: Chromosome segregation during mitosis explained  SCIENCE DAILY · 4 weeks
Researchers shed light on the protein complexes and processes that enable microtubules to bind to the centromeres of chromosomes and redistribute them to the daughter cells during mitosis. Via experiments... more
A bacterial protein is found to promote cancer  SCIENCE DAILY · 6 days
Researchers have discovered that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell's ability to respond to and repair DNA damage, a known origin of cancer. more
By solving a mystery of gene repair, scientists uncover an exception to biology's rules  PHYS.ORG · 4 weeks
About 15 years ago, UNC Lineberger's Dale Ramsden, Ph.D., was looking through a textbook with one of his students when... more
The protein that spurs dormant bacteria into reproduction  SCIENCE DAILY · 2 weeks
Whether dormant bacteria begin to reproduce is no accident. Rather, they are simply waiting for a clear signal from a single protein in the cell interior. Researchers have now deciphered the molecular... more
It's Official! NASA's Famed Voyager 2 Spacecraft Reaches Interstellar Space
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NASA's Voyager 2 probe enters interstellar space
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Lund University researchers succeed in obtaining dendritic cells by direct reprogramming
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NASA's InSight Mars Lander 'Hears' Martian Wind, a Cosmic First
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ESA
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Fresh