Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors, a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell's ability to dispose of misfolded proteins.... NEWS MEDICAL · 2 months
Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers  NEWS MEDICAL · 22 hours
Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a... more
Neurotransmitter that helps cancers progress IDed  SCIENCE DAILY · 1 day
Using human cancer cells, tumor and blood samples from cancer patients, researchers have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical ''messengers'' that transmit impulses from neurons to other... more
HPV-negative cervical cancers are more aggressive with worse prognosis  NEWS MEDICAL · 1 week
Cervical cancer negative for the human papilloma virus (HPV) is rare but more aggressive: it is more frequently diagnosed at advanced stages, with more metastasis and reduced survival. more
Shutting down deadly pediatric brain cancer at its earliest moments  SCIENCE DAILY · 2 weeks
Cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer allowed scientists to discover a molecular driver of the highly aggressive, deadly,... more
Federal study gives new options for people with rare cancers  ABC NEWS · 3 weeks
Study suggests way to tell which patients with rare cancers may benefit from immune system-boosting drugs more
New potential therapeutic target for pancreatic cancer discovered  SCIENCE DAILY · 4 weeks
Cancer cells demand enormous amounts of molecular 'food' to survive and grow, and a new study may have identified a new approach to starve the cells of one of the most common... more
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq  Science Magazine · 1 week
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct... more
Genes linked with the most common liver cancer  SCIENCE DAILY · 2 weeks
Researchers have provided the first summary of the experimental evidence supporting the AKR1B10 enzyme as a promising therapeutic target for Hepatocellular carcinoma (HCC), based on a review of more than 50 studies... more
BRAF protein modification could slow tumor growth  SCIENCE DAILY · 1 day
Researchers have discovered a signaling pathway between cytokines and BRAF that promotes tumor growth. The finding could provide a potential therapeutic target. more
Pediatric patients undergoing thyroid surgery have better outcomes at high-volume centers  NEWS MEDICAL · 3 weeks
New research recently published in the Journal of Pediatric Surgery found that post-operative success rates of pediatric thyroid patients, particularly children who require a thyroidectomy, correlate... more
Researchers discover how tumor-killing immune cells attack lymphomas in living mice  SCIENCE DAILY · 3 weeks
Researchers reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these... more
Scientists decipher 3D structure of a promising molecular target for cancer treatment  SCIENCE DAILY · 3 weeks
Researchers have revealed the full structure of human ACLY, a building block of metabolism over-expressed in several types of cancers. Their discovery could be... more
New nanomedicine slips through the cracks  PHYS.ORG · 2 days
In a recent study in mice, researchers found a way to deliver specific drugs to parts of the body that are exceptionally difficult to access. Their Y-shaped block catiomer (YBC) binds with certain therapeutic materials forming... more
Salk researchers reveal new role for a driver of metastatic cancers  NEWS MEDICAL · 3 weeks
Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, Salk Institute researchers have revealed a new role for the CDK12... more
New computational model of human kinase may provide insights for cancer drug development  NEWS MEDICAL · 3 weeks
Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human... more
Lurie Children's introduces virtual reality into pediatric ICU  NEWS MEDICAL · 4 weeks
For the first time in a pediatric intensive care unit, patients get a chance to scuba dive, snowboard, and go on a safari or other adventures, all from their hospital bed. more
New role for a driver of metastatic cancers  SCIENCE DAILY · 3 weeks
Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, researchers have revealed a new role for the CDK12 protein. more
New nanomedicine slips through the cracks, reaches brain  SCIENCE DAILY · 2 days
In a recent study in mice, researchers found a way to deliver specific drugs to parts of the body that are exceptionally difficult to access. Their Y-shaped block catiomer (YBC) binds with... more
Computational model of a human kinase may provide insights for cancer treatment  SCIENCE DAILY · 3 weeks
Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers. This... more
Researchers pinpoint tumor-related protein, slow progression of cancers  SCIENCE DAILY · 1 week
A new study has identified a potential strategy for treating multiple forms of cancerous tumors: targeting a protein that maliciously rewires immune cells and impedes cancer therapies. The researchers showed that inhibiting... more
[Editors' Choice] Targeting senescence within the Alzheimers plaque  Science Magazine · 1 week
Amyloid β drives senescence of oligodendrocyte progenitor cells, presenting a potential therapeutic target. more
Pediatric cell atlas will map single-cell changes for a deeper view of child health and disease  SCIENCE DAILY · 4 weeks
Biomedical researchers plan to create the Pediatric Cell Atlas, a powerful new resource for fine-grained scientific... more
Researchers unravel 3D structure of key molecular target for cancer treatment  NEWS MEDICAL · 3 weeks
Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment. more
Mechanism of resistance to BRAF inhibitors in melanoma identified  SCIENCE DAILY · 1 week
Melanoma is one of the most aggressive types of skin cancer, but recent advances in targeted therapies have improved the prognosis for many patients. Unfortunately, for some patients these positive... more
Fishing for cures: New zebrafish model identifies drugs that kill pediatric cancer cells  SCIENCE DAILY · 10 hours
A new immunodeficient zebrafish model investigators promises to be less expensive, easier to use and to improve personalized therapies for cancers and... more
Marking the start of Pediatric Sepsis Week  NEWS MEDICAL · 3 days
On April 21st, Sepsis Alliance launched Pediatric Sepsis Week to raise awareness of the signs and symptoms of sepsis in children. more
New study finds that screening could help prevent rare types of cervical cancer  NEWS MEDICAL · 3 weeks
Rare types of cervical cancer can be effectively prevented with screening, a comprehensive study of identified cases of rare cervical cancer over... more
Study suggests novel therapeutic strategy for ALS  NEWS MEDICAL · 2 weeks
In a study published online in Brain on April 1, researchers from Dr. XU Jin's lab at the Institute of Neuroscience of the Chinese Academy of Sciences and their collaborators revealed a new cellular... more
Molecular target UNC45A is essential for cancer but not normal cell proliferation  PHYS.ORG · 7 days
Identifying a protein that plays a key role in cancer cell growth is a first step toward the development of a targeted cancer therapy.... more
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