Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.... NEWS MEDICAL · 2 months
New therapeutic approach for patients with pancreatic cancer  NEWS MEDICAL · 2 weeks
One-year survival is low among patients diagnosed with pancreatic cancer. Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic... more
GARP protein can be a potential target for immunotherapy against colorectal cancer  NEWS MEDICAL · 3 days
Colorectal cancer is the third leading cause of cancer-related deaths in both men and women. Despite significant advances in therapies for this particular cancer,... more
The story of GARP: A potential target for cancer immunotherapy  SCIENCE DAILY · 4 days
Researchers reveal how the cell surface receptor GARP plays a role in T regulatory cell function and migration to the gut. Because the presence of T regulatory cells... more
Potential new combination treatment for pancreatic cancer  SCIENCE DAILY · 2 days
Researchers have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers. more
Inherited mutations may play a role in pancreatic cancer development  SCIENCE DAILY · 3 weeks
A small, retrospective study has found that, in patients with particular pancreatic duct lesions, the presence of an inherited mutation in a pancreatic cancer susceptibility gene may increase... more
Promising new pancreatic cancer treatment moves forward  SCIENCE DAILY · 3 weeks
A new study describes a new therapeutic approach with potential for patients with pancreatic cancer. These researchers discovered a combination drug therapy that may effectively combat the disease. Researchers first observed anti-cancer impacts in... more
New therapeutic approach offers promise for patients with pancreatic cancer  NEWS MEDICAL · 2 weeks
Lustgarten Foundation and Stand Up To Cancer, strategic partners in the Pancreatic Cancer Collective, offer comments on research published today in the journal Nature Medicine which describes a... more
Mayo Clinic researchers identify gene that may predict pancreatic cancer risk in diabetic patients  NEWS MEDICAL · 4 weeks
Mayo Clinic researchers have identified a gene called "UCP-1" that may predict the development of pancreatic cancer in people with... more
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy  Science Magazine · 4 weeks
While a fraction of cancer patients treated with anti–PD-1 show durable therapeutic responses, most remain unresponsive, highlighting the need to better understand and improve these therapies. Using an in vivo screening approach... more
Medical News Today: Pancreatic cancer: Two-hit treatment approach shows promise  MNT · 2 weeks
Autophagy inhibitors could be more potent against pancreatic cancer by first applying a drug that makes the cancer cells dependent on autophagy for energy. more
New combinational drug therapy may effectively combat pancreatic cancer  NEWS MEDICAL · 2 weeks
Even among cancers, pancreatic cancer is an especially sinister form of disease. The one-year survival rate is extremely low, and treatment progress has lagged behind that of many other malignancies. more
Genomics could better match treatments to pancreatic cancer patients  SCIENCE DAILY · 3 weeks
Pancreatic cancer is a grim diagnosis, but this new study, the largest of its kind, identifies genomic markers that could increase survival by better matching chemotherapy drugs to patients. more
Researchers discover possible new therapeutic strategy for pancreatic cancer  NEWS MEDICAL · 1 day
Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers. more
Enzyme USP15 may have potential role in future treatment of various cancers  SCIENCE DAILY · 7 days
A team has found that the deubiquitinating enzyme USP15 is a potential biomarker for treatments of pancreatic cancer, as well as ovarian and breast... more
Genomics could guide treatment for pancreatic cancer patients  NEWS MEDICAL · 2 weeks
Pancreatic cancer is a grim diagnosis, with a five-year survival rate of less than 9 percent. To improve those odds, researchers at UPMC and the University of Pittsburgh School of Medicine sought... more
Combination immunotherapy could stop liver cancer growth  SCIENCE DAILY · 1 week
New preclinical data offers proof-of-principle for a combination immunotherapy that suppresses tumor growth in the liver. Current therapies for liver cancer are largely ineffective, resulting in poor outcomes. more
Precision cancer drugs spark powerful immune response and boost effects of immunotherapy  NEWS MEDICAL · 2 weeks
Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from... more
Balance of two enzymes linked to pancreatic cancer survival  SCIENCE DAILY · 2 days
New research sets the stage for clinicians to potentially one day use levels of a pancreatic cancer patient's PHLPP1 and PKC enzymes as a prognostic, and for researchers to develop... more
USP15 enzyme could potentially lead to new treatments for breast, pancreatic cancer  NEWS MEDICAL · 7 days
Researchers at the George Washington University Cancer Center found that the enzyme USP15 could potentially lead to new treatments for breast and pancreatic cancer.... more
Alex Trebek's Pancreatic Cancer: What Does Stage 4 Mean for His Survival?  LIVE SCIENCE · 2 weeks
'Jeopardy!' host Alex Trebek has revealed that he been diagnosed with stage 4 pancreatic cancer. more
Alex Trebek's Pancreatic Cancer: What Does Stage 4 Mean?  LIVE SCIENCE · 2 weeks
'Jeopardy!' host Alex Trebek has revealed that he been diagnosed with stage 4 pancreatic cancer. more
New gene hunt reveals potential breast cancer treatment target  SCIENCE DAILY · 2 weeks
Researchers have developed a way to discover elusive cancer-promoting genes, already identifying one that appears to promote aggressive breast cancers. The team developed a statistical approach to reveal many previously... more
How prostate cancer becomes treatment resistant  SCIENCE DAILY · 3 weeks
Scientists have identified how prostate cancer transforms into a deadly treatment-resistant prostate cancer subtype called neuroendocrine prostate cancer (NEPC) following treatment with anti-androgen therapy. Their findings -- which include the metabolic rewiring and the epigenetic alteration... more
Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma  NEWS MEDICAL · 3 weeks
Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous,... more
Oral bacteria in pancreas linked to more aggressive tumors  SCIENCE DAILY · 1 week
The presence of oral bacteria in so-called cystic pancreatic tumours is associated with the severity of the tumour, researchers report. It is hoped that the results can help to improve... more
Oral bacteria in pancreas associated with tumor severity  NEWS MEDICAL · 1 week
The presence of oral bacteria in so-called cystic pancreatic tumours is associated with the severity of the tumour, a study by researchers at Karolinska Institutet in Sweden published in the journal Gut... more
Precision drugs could unmask cancers to immune system and boost effects of immunotherapy  SCIENCE DAILY · 2 weeks
Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients... more
A new approach to drugging a difficult cancer target  PHYS.ORG · 1 week
One of the most common cancer-promoting genes, known as Myc, is also one of the most difficult to target with drugs. Scientists have long tried to develop drugs that block... more
Preclinical data shows combination immunotherapy could suppress tumor growth in the liver  NEWS MEDICAL · 1 week
Even as overall cancer incidence and mortality decrease in the United States, the number of people diagnosed with liver cancer is on the rise. more
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