The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.... MIT · 1 week
New CRISPR platform expands RNA editing capabilities  PHYS.ORG · 1 week
CRISPR-based tools have revolutionized our ability to target disease-linked genetic mutations. CRISPR technology comprises a growing family of tools that can manipulate genes and their expression, including by targeting DNA with the enzymes Cas9... more
A cytosine deaminase for programmable single-base RNA editing  Science Magazine · 1 week
Programmable RNA editing enables reversible recoding of RNA information for research and disease treatment. Previously, we developed a programmable A to I RNA editing approach by fusing catalytically inactivated RNA-targeting CRISPR-Cas13 (dCas13)... more
Nanoparticles used to deliver CRISPR gene editing tools into the cell  NEWS MEDICAL · 7 days
Researchers from Tufts University and the Chinese Academy of Sciences have developed a novel method to effectively deliver the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat... more
Better genome editing for bioenergy  PHYS.ORG · 6 days
CRISPR-Cas9 is a powerful, high-throughput gene-editing tool that can help scientists engineer organisms for bioenergy applications. Cas9 needs guide RNA to lead it to the correct sequence to snip—but not all guides are effective. To ensure the gene... more
Novel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency  SCIENCE DAILY · 1 week
Researchers have developed a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver. The delivery uses... more
Novel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency  nanowerk · 1 week
Researchers used lipid nanoparticles to deliver CRISPR/Cas9 gene editing tools for potential treatment of hyperlipidemia. more
Novel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency  PHYS.ORG · 1 week
A research collaboration between Tufts University and the Chinese Academy of Sciences has led to the development of a significantly... more
Broad Institute researchers use novel field-ready CRISPR platform to detect plant genes  PHYS.ORG · 4 weeks
SHERLOCK technology is a new CRISPR-based platform that is rapid and portable and enables detection and quantitation of plant genes to support a variety... more
'Scissors' component of CRISPR/Cas9 sometimes gets stuck  NEWS MEDICAL · 3 weeks
In biotech these days, CRISPR/Cas9 is a hot topic, because of its utility as a precise gene editing tool. Before humans repurposed it, CRISPR/Cas9 was a sort of internal immune system bacteria use to... more
Scissors get stuck: Another way bacteria use CRISPR/Cas9  SCIENCE DAILY · 3 weeks
Before humans repurposed it as a gene editing tool, CRISPR/Cas9 was a sort of internal immune system bacteria use to defend themselves against phages. Scientists have found that the 'scissors' component of... more
Scissors get stuck—another way bacteria use CRISPR/Cas9  PHYS.ORG · 3 weeks
In biotech these days, CRISPR/Cas9 is a hot topic, because of its utility as a precise gene editing tool. Before humans repurposed it, CRISPR/Cas9 was a sort of internal immune system bacteria use to... more
First hi-res images of active CRISPR enzyme will help improve genome editing  nanowerk · 2 weeks
For the first time, scientists grappling with how to improve the efficiency of CRISPR technology have captured atomic-level, three-dimensional images of the enzyme before... more
Linking phenotypes to genotypes: A newly devised gene-editing strategy  SCIENCE DAILY · 2 weeks
Scientists have developed a new methodology that allows the study of CRISPR-mediated effects in cells while accurately ascertaining the exact DNA changes that caused them. This novel protocol is opening... more
Preventing hereditary deafness  SCIENCE DAILY · 2 weeks
An optimized version of the CRISPR-Cas9 gene-editing system prevents hearing loss with no detectable off-target effects in so-called Beethoven mice, which carry a mutation that causes profound hearing loss in humans and mice alike. Results offer proof of principle for... more
New study on gene editing in wildlife finds people are wary  PHYS.ORG · 4 weeks
The applications of CRISPR based genetic engineering tools range from changing colors in butterfly wings to developing gene therapies that might one day cure or prevent... more
A NEAT discovery about memory  SCIENCE DAILY · 3 weeks
Researchers say over expression of NEAT1, an noncoding RNA, appears to diminish the ability of older brains to form memories. Inhibiting NEAT1 via CRISPR technology could be a means to improve memory in older humans. more
Why the 'molecular scissors' metaphor for understanding CRISPR is misleading  PHYS.ORG · 2 weeks
Last week I read an article about CRISPR, the latest tool scientists are using to edit DNA. It was a great piece—well researched, beautifully written, factually accurate. It... more
Comprehensive review of the future of CRISPR technology in crops  SCIENCE DAILY · 6 days
CRISPR is thought of as 'molecular scissors' used to cut and edit DNA, but researchers are now looking far beyond these applications. In a new comprehensive review, they... more
Researchers develop a more precise version of CRISPR-Cas9 gene-editing system  NEWS MEDICAL · 3 days
A gene defect in humans causes progressive hearing loss in humans, resulting in deafness by their mid-20s. The same genetic mutation causes deafness in the Beethoven-mouse model. more
Successful T cell engineering with gene scissors  SCIENCE DAILY · 1 week
The idea of genetically modifying a patient's own immune cells and deploying them against infections and tumors has been around since the 1980s. But to this day modified T cells are still not as... more
Successful T cell engineering with gene scissors  PHYS.ORG · 1 week
The idea of genetically modifying a patient's own immune cells and deploying them against infections and tumors has been around since the 1980s. But to this day modified T cells are still not as... more
New genome editing technology for plant breeding  PHYS.ORG · 3 days
Researchers have developed a new genome editing technology for rice, combining adenine-to-guanine single-base editing technology and Cas9 with an extended targeting scope. They report that it is possible to efficiently introduce base substitution mutations... more
Healthy mice pups can be produced from sperm without short RNA chains  NEWS MEDICAL · 3 weeks
Scientists from the University of Bath are challenging the claims of two high profile papers from 2018 which reported that in the mouse, RNA... more
Researchers Capture High-Resolution Images of Active Cas9 Enzyme  SCI-NEWS.COM · 1 week
Using a technique called cryogenic electron microscopy (cryo-EM), a team of scientists from the United States and Canada has captured... more
Structural basis for the multitasking nature of the potato virus Y coat protein  Science Magazine · 4 days
Potato virus Y (PVY) is among the most economically important plant pathogens. Using cryoelectron microscopy, we determined the near-atomic structure of PVY’s... more
New study challenges claim that exogenous RNA is essential for sperm function  SCIENCE DAILY · 3 weeks
Scientists are challenging the claims of two high profile papers from 2018 which reported that in the mouse, RNA has to be added to... more
New study challenges claim that exogenous RNA is essential for sperm function  PHYS.ORG · 3 weeks
Scientists from the University of Bath are challenging the claims of two high profile papers from 2018 which reported that in the mouse, RNA... more
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