Scientists at Johns Hopkins Medicine report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size—even hefty ones attached to the gene-editing tool called CRISPR. If their creation—constructed of a biodegradable polymer—passes more laboratory testing, it could offer a way to efficiently ferry larger medical compounds into specifically selected target cells.... PHYS.ORG · 2 months
New uses for old medicines  NEWS MEDICAL · 2 days
It turns out that in the rush to invent new drugs to treat cancers, scientists may have overlooked some obvious possibilities of existing drugs currently being used for other diseases. A new study says that therapies for diabetes,... more
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In preclinical experiments, investigators restored p53 using synthetic mRNA nanoparticles, making lung and liver cancer cells susceptible to available cancer drugs. more
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Physicists design 'super-human' red blood cells to deliver drugs to specific targets  SCIENCE DAILY · 6 days
A team of physicists from McMaster University has developed a process to modify red blood cells so they can be used to distribute drugs... more
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Sodium chloride nanoparticles offer potential for cancer therapies with fewer side effects  NEWS MEDICAL · 2 weeks
A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient.... more
Cells protect themselves against stress by keeping together  SCIENCE DAILY · 6 days
For the first time, research shows that the contacts between cells, known as cell adhesion, are essential for cells to survive stress. The findings also suggest that impaired cell adhesion may sensitize... more
Study uncovers anticancer potential of many non-oncology drugs  NEWS MEDICAL · 2 days
Drugs for diabetes, inflammation, alcoholism -- and even for treating arthritis in dogs -- can also kill cancer cells in the lab, according to a study by scientists at the Broad Institute... more
Virus used in gene therapies may pose cancer risk, dog study hints  Science Magazine · 2 weeks
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Nanoparticles deliver 'suicide gene' therapy to pediatric brain tumors growing in mice  SCIENCE DAILY · 2 weeks
Researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a ''suicide gene'' to pediatric brain tumor cells implanted in... more
Study finds salt nanoparticles are toxic to cancer cells  PHYS.ORG · 2 weeks
A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient. Sodium chloride nanoparticles—more commonly known as... more
Biodegradable nanoparticle can deliver 'suicide gene' to pediatric brain tumor cells in mice  NEWS MEDICAL · 2 weeks
Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain... more
Nanoparticles deliver 'suicide gene' therapy to pediatric brain tumors growing in mice  PHYS.ORG · 2 weeks
Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain tumor cells... more
Cancer study may accidentally help researchers create usable blood stem cells  SCIENCE DAILY · 6 days
A new study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort... more
Disordered chromatin packing regulates phenotypic plasticity  Science Magazine · 2 weeks
Three-dimensional supranucleosomal chromatin packing plays a profound role in modulating gene expression by regulating transcription reactions through mechanisms such as gene accessibility, binding affinities, and molecular diffusion. Here, we use a computational model that integrates disordered... more
Study finds salt nanoparticles are toxic to cancer cells  nanowerk · 2 weeks
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New function for potential tumor suppressor in brain development  PHYS.ORG · 2 weeks
The gene Cdkn1c could have been considered an open-and-shut case: Mice in which the gene is removed are larger and have bigger brains, so Cdkn1c should function to inhibit growth.... more
Scientists develop 'Twitter' for cells  PHYS.ORG · 2 weeks
Computational biologists led by Prof. Yvan Saeys (VIB-UGent Center for Inflammation Research) developed a new bioinformatics method to better study communication between cells. This method, called NicheNet, helps researchers to gain insight into how the gene expression of... more
Nanoparticles deliver 'suicide gene' therapy to pediatric brain tumors growing in mice  nanowerk · 2 weeks
Medical researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a 'suicide gene' to pediatric brain tumor cells implanted... more
Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency  NEWS MEDICAL · 4 weeks
University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications. more
For CRISPR, tweaking DNA fragments before inserting yields highest efficiency rates yet  PHYS.ORG · 1 month
University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for... more
New route for tackling drug resistance in skin cancer cells  SCIENCE DAILY · 1 week
Researchers have found that melanoma cells fight anti-cancer drugs by changing their internal skeleton (cytoskeleton) -- opening up a new therapeutic route for combating skin and other cancers... more
The perfect tempo within the cells to develop vertebrae  PHYS.ORG · 2 weeks
Timing is everything when it comes to the embryonic development of pre-vertebrae divisions along the body of an embryo, according to researchers in Japan. A new live-imaging technique in mouse... more
New roles found for Huntington's disease protein  SCIENCE DAILY · 5 hours
A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic mouse models, they have discovered that... more
New mechanisms describe how the genome regulates itself  PHYS.ORG · 6 days
An organism's genome contains all of the information necessary for each of its cells and tissues to develop and function properly. Written in DNA, each individual gene encodes for something, whether it... more
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