T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high-affinity, isotype-switched antibodies. In a forward genetic screen, we identified a missense mutation in Prkd2, encoding the serine/threonine kinase protein kinase D2, which caused elevated titers of immunoglobulin E (IgE) in the serum. Subsequent analysis of serum antibodies in mice with a targeted null mutation of Prkd2 demonstrated polyclonal hypergammaglobulinemia o... Science Magazine · 1 month
A cell atlas of human thymic development defines T cell repertoire formation  Science Magazine · 1 week
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Researchers at the Biozentrum of the University of Basel have discovered a "clockwork" mechanism that controls cell division in bacteria. In two publications, in Nature Communications and PNAS,... more
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The most prevalent pathogenic mutations in the CFTR (F508) and SLC26A4/pendrin (p.H723R), which cause cystic fibrosis and congenital hearing loss, respectively, evoke protein misfolding and subsequent defects in... more
Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates  Science Magazine · 2 weeks
Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion.... more
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Ecological differentiation is correlated with taxonomic diversity in many clades, and ecological divergence is often assumed to be a cause and/or consequence of high speciation rate. However, an analysis of... more
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Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and... more
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Genetics of schizophrenia in the South African Xhosa  Science Magazine · 4 weeks
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Mammalian sexual reproduction relies on the dichotomy of male and female germ cell development. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional... more
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Cluster of Differentiation 20 (CD20) is a B cell membrane protein that is targeted by monoclonal antibodies for the treatment of malignancies and auto-immune disorders, but... more
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Scientists have discovered new filamentous structures within plant cell walls that influence cell growth and help build complex three-dimensional cell shapes. more
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