T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high-affinity, isotype-switched antibodies. In a forward genetic screen, we identified a missense mutation in Prkd2, encoding the serine/threonine kinase protein kinase D2, which caused elevated titers of immunoglobulin E (IgE) in the serum. Subsequent analysis of serum antibodies in mice with a targeted null mutation of Prkd2 demonstrated polyclonal hypergammaglobulinemia o... Science Magazine · 1 month
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The most prevalent pathogenic mutations in the CFTR (F508) and SLC26A4/pendrin (p.H723R), which cause cystic fibrosis and congenital hearing loss, respectively, evoke protein misfolding and subsequent defects in... more
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Ecological differentiation is correlated with taxonomic diversity in many clades, and ecological divergence is often assumed to be a cause and/or consequence of high speciation rate. However, an analysis of... more
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What makes a 'good Samaritan' good? That opinion depends on the beneficiary  SCIENCE DAILY · 2 weeks
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Genetics of schizophrenia in the South African Xhosa  Science Magazine · 4 weeks
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ZGLP1 is a determinant for the oogenic fate in mice  Science Magazine · 2 weeks
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