Doctors have successfully treated an infant with a rare childhood leukemia using a targeted therapy approved for adults with inoperable liver cancer and advanced kidney cancer. The decision to use the drug, sorafenib, was made after pathologists identified a unique mutation of two genes being fused together instead of on separate chromosomes.... SCIENCE DAILY · 5 months
Study may help develop ibrutinib-based combination therapies for blood cancer  NEWS MEDICAL · 3 weeks
Chronic lymphocytic leukemia (CLL) is the most common form of blood cancer (leukemia) in the Western world, affecting approximately 1.2% of all cancer patients. more
Cedars-Sinai researchers to study role of fat in promoting cancer spread to liver  NEWS MEDICAL · 2 weeks
A diagnosis of pancreatic or colon cancer often sparks dread about the disease's likely next destination: the liver. That's because liver metastasis... more
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia  Science Magazine · 3 weeks
The initiating mutations that contribute to cancer development are sometimes present in premalignant cells. Whether therapies targeting these... more
Study identifies two possible targets to halt liver damage in NASH  NEWS MEDICAL · 2 weeks
As much as 12 percent of adults in the United States are living with nonalcoholic steatohepatitis (NASH), an aggressive condition that can lead to cirrhosis or... more
Call for FDA to withdraw preterm birth drug divides doctors and insurers  NEWS MEDICAL · 3 weeks
Doctors fear that the only drug approved to prevent preterm birth, the nation’s leading cause of infant mortality and disability, will no longer be... more
Scientists discover new drug target for prostate cancer in the non-coding genome  NEWS MEDICAL · 4 weeks
Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design. more
Why new cancer drugs take so long to reach the market  NEWS MEDICAL · 3 weeks
A new analysis of cancer drug development by researchers at the Institute of Cancer Research, London, shows that the more revolutionary a new cancer drug is,... more
FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy  NEWS MEDICAL · 2 weeks
Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the... more
Combination drug therapy for childhood brain tumors shows promise in laboratory models  SCIENCE DAILY · 2 days
In experiments with human cells and mice, researchers report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer... more
Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases  Science Magazine · 2 weeks
Liver metastases often progress from primary cancers including uveal melanoma (UM), breast, and colon cancer. Molecular biomarker imaging is a... more
Scientists discover how rogue communications between cells lead to leukemia  SCIENCE DAILY · 2 weeks
New research has deciphered how rogue communications in blood stem cells can cause leukemia. The discovery could pave the way for new, targeted medical treatments that block this... more
Cerium oxide nanoparticles may improve hepatocellular carcinoma prognosis  PHYS.ORG · 1 week
Hepatocellular carcinoma is the most common liver cancer and ranks third in the world in terms of mortality. Its appearance is related to the hepatitis B and C viruses, alcoholism, metabolic diseases... more
CAR T treatments could have fewer side effects than other cancer immunotherapies  PHYS.ORG · 3 weeks
New cancer immunotherapies involve extracting a patient's T cells and genetically engineering them so they will recognize and attack tumors. This technique is a... more
A two-drug combo that halts growth of cancer cells discovered  NEWS MEDICAL · 4 weeks
UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations. more
Low-protein diet throughout pregnancy and lactation may increase risk of liver damage  NEWS MEDICAL · 3 weeks
A study in rats examines a pathway through which protein deficiency during pregnancy leads to fat accumulation in the liver and increased risk of... more
Association between HMO concentrations and infant weight, body composition  NEWS MEDICAL · 7 hours
Breastfeeding affects infant growth and, researchers have found, helps prevent obesity, both in childhood and later in life. However, the components of breast milk responsible for these beneficial effects remain... more
New target protein linked to regulation, movement of tumor-associated macrophages  NEWS MEDICAL · 3 weeks
Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer owes its notorious identity to the fact that the cancer cells... more
Researchers examine abnormal neuron activity in Rett syndrome  NEWS MEDICAL · 3 weeks
The brain undergoes dramatic change during the first years of life. Its circuits readily rewire as an infant and then child encounters new sights and sounds, taking in the world and learning... more
Is the new virus more 'deadly' than flu? Not exactly  ABC NEWS · 12 hours
There's lots of confusion about how deadly the new coronavirus from China really is: Even health officials sometimes say "deadly" when they may mean "lethal." more
Skin-to-skin contact do not improve interaction between mother and preterm infant  SCIENCE DAILY · 4 weeks
Following a premature birth it is important that the parents and the infant quickly establish a good relationship. Researchers have studied the relationship between mothers and... more
Combination therapy for pediatric low-grade gliomas shows promise in mice  NEWS MEDICAL · 2 days
In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with... more
Researchers identify liver fibrosis ‘off switch’ in mice  NEWS MEDICAL · 4 weeks
Chronic alcohol abuse and hepatitis can injure the liver, often leading to a buildup of collagen and scar tissue. more
Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms  Science Magazine · 2 weeks
Secondary drug resistance stems from dynamic clonal evolution during the development of a prior primary resistance. This collateral type of resistance is often a characteristic of... more
Two-drug combo halts the growth of cancer cells  SCIENCE DAILY · 4 weeks
Researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations. more
Dozens of non-oncology drugs can kill cancer cells  SCIENCE DAILY · 4 weeks
Researchers tested approximately 4,518 drug compounds on 578 human cancer cell lines and found nearly 50 that have previously unrecognized anti-cancer activity. These drugs have been used to treat conditions such as... more
FerriIridium drug can simultaneously help diagnose, treat gastric cancer  NEWS MEDICAL · 4 weeks
A novel drug, named "FerriIridium", can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching... more
Chemical in veggies help heal fatty liver  NEWS MEDICAL · 1 week
A new study shows that a compound naturally occurring in a variety of commonly used vegetables as well as being produced by gut microbes is very useful in melting fat away from a fatty... more
An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis  Science Magazine · 2 weeks
Liver cell death has an essential role in nonalcoholic steatohepatitis (NASH). The activity of the energy sensor adenosine monophosphate (AMP)–activated protein kinase (AMPK) is repressed in NASH. Liver-specific AMPK knockout... more
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