Host-cell enzymes called PARP12 and PARP14 are important for inhibiting mutant forms of a coronavirus, according to a study published May 16 in the open-access journal PLOS Pathogens by Stanley Perlman of the University of Iowa, Anthony Fehr of the University of Kansas, and colleagues.... PHYS.ORG · 3 months
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death  Science Magazine · 2 days
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and confer disease resistance by unknown mechanisms. We demonstrate that plant Toll/interleukin-1... more
Study examines the role of enzymes in stress regulation mechanisms  NEWS MEDICAL · 2 weeks
Scientists of South Ural State University are studying enzymes that can break down stress hormones. They are also finding a way to regulate the activity of these enzymes.... more
Power generation achieved by a self-assembled biofuel cell  PHYS.ORG · 3 weeks
Researchers have developed the first fully functional biofuel cell whose biocatalysts (enzymes that play a critical role in power generation) directly self-assemble onto the electrodes. In about 5 minutes, enzyme-nanoparticle hybrids added... more
Scientists create artificial catalysts inspired by living enzymes  PHYS.ORG · 3 weeks
All living organisms depend on enzymes—molecules that speed up biochemical reactions that are essential for life. more
N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication  Science Magazine · 2 days
Host cell metabolism can be modulated by viral infection, affecting viral survival or clearance. The cellular metabolism rewiring mediated by N6-methyladenosine (m6A) modification in virus-host interaction remains largely unknown. Here... more
'Yin and yang' enzymes evolved over billions of years to protect against cancer  PHYS.ORG · 3 days
Researchers at the University of Dundee have made an important discovery about two enzymes that have evolved over billions of years to... more
Two therapeutic targets identified for deadly lung cancer  SCIENCE DAILY · 4 weeks
The vast majority of deadly lung cancer cases (85 percent) are termed non-small-cell lung carcinomas (NSCLCs), which often contain a mutated gene called LKB1. Researchers have now discovered precisely why inactive LKB1... more
E-cigs can trigger same lung changes seen in smokers, emphysema  SCIENCE DAILY · 2 days
Scientists found that the lungs of vapers -- like the lungs of smokers -- have elevated levels of protease enzymes, a condition known to cause emphysema in smokers.... more
Rice, UTHealth researchers search for clues to combat antibiotic resistance  NEWS MEDICAL · 2 weeks
To combat the rise of drug-resistant bacteria, researchers are examining how one superbug adapts to fight an antibiotic of last resort, hoping to find clues that can prolong... more
Natural gas storage research could combat global warming  SCIENCE DAILY · 2 weeks
To help combat global warming, a team is working on a new porous polymer that can store natural gas more effectively than anything currently being used. more
T cell-mediated regulation of the microbiota protects against obesity  Science Magazine · 1 month
The microbiota influences obesity, yet organisms that protect from disease remain unknown. During studies interrogating host-microbiota interactions, we observed the development of age-associated metabolic syndrome (MetS). Expansion of Desulfovibrio and... more
Scientists uncover mystery of DNA methylation  SCIENCE DAILY · 5 days
To a large extent, DNA methylation, which regulates vital cell functions, is still a big mystery to the scientific world. Now,, scientists have developed a method to quickly couple methylation enzymes to their respective methylation pattern.... more
Study forms basis for therapeutic strategies to combat cancers caused by HMGA1a  NEWS MEDICAL · 4 weeks
The researchers led by Professor Raphael Stoll therefore expect their results to form a basis for future therapeutic strategies to combat cancers caused by... more
Map of malaria behavior set to revolutionize research  SCIENCE DAILY · 1 day
The first detailed map of individual malaria parasite behavior across each stage of its complicated life cycle has been created by scientists. Researchers used advanced single-cell technology to isolate individual parasites and... more
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle  Science Magazine · 2 days
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We... more
Rhizobial tRNA-derived small RNAs are signal molecules regulating plant nodulation  Science Magazine · 1 month
Rhizobial infection and root nodule formation in legumes requires recognition of signal molecules produced by the bacteria and their hosts. Here we show that rhizobial tRNA-derived small RNA... more
Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss  Science Magazine · 3 days
Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine... more
Physiological mechanisms leading to enterovirus opening revealed  SCIENCE DAILY · 1 week
Enteroviruses are one of the most common human pathogens leading to high number of acute and chronic infections worldwide. The physiological events leading to successful enterovirus infection are still poorly understood. Researchers have found... more
Expression of M gene segment of influenza A virus determines host range  SCIENCE DAILY · 1 week
The host range of the influenza A virus (IAV) is restricted by dysregulated expression of the M viral gene segment, according to a new... more
Stem cell differentiation trajectories in Hydra resolved at single-cell resolution  Science Magazine · 1 month
The adult Hydra polyp continually renews all of its cells using three separate stem cell populations, but the genetic pathways enabling this homeostatic tissue maintenance are not well... more
Influenza A virus host range restricted by dysregulated expression of M gene segment  NEWS MEDICAL · 1 week
The host range of the influenza A virus is restricted by dysregulated expression of the M viral gene segment, according to a... more
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes  Science Magazine · 3 days
Age-associated changes in CD4 T-cell functionality have been linked to chronic inflammation and decreased immunity. However, a detailed... more
Physiological mechanisms leading to enterovirus opening revealed  PHYS.ORG · 5 days
Enteroviruses are one of the most common human pathogens leading to high number of acute and chronic infections worldwide. The physiological events leading to successful enterovirus infection are still poorly understood. Researchers at the... more
Plan B for cholesterol transport  PHYS.ORG · 1 week
Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighboring cells and the surrounding environment. By... more
New lipid signaling target may improve T cell immunotherapy  SCIENCE DAILY · 5 days
T cell immunotherapy uses the immune system to kill cancer cells. To increase the efficacy of this new treatment, researchers aimed to discover a master regulator of T cell fate.... more
Assessing direct-to-consumer stem cell clinics  SCIENCE DAILY · 3 weeks
This direct-to-consumer stem cell marketplace has come under increasing scrutiny, but relatively little is known about the clinics or how the treatments they offer align with the expertise of their practitioners. Investigators now offer a detailed characterization of... more
Discovery of new liver cell could make liver transplants redundant  NEWS MEDICAL · 4 weeks
Researchers at King's College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure... more
Liver transplants could be redundant with discovery of new liver cell  SCIENCE DAILY · 4 weeks
Researchers have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the... more
ISCT expresses concern about companies offering unproven T-cell preservation services  NEWS MEDICAL · 2 weeks
ISCT, the International Society for Cell and Gene Therapy, the global professional society of clinicians, researchers, regulatory specialists, technologists and industry partners in the cell and gene therapy... more
Skin in balance: Joint forces of polarity and cell mechanics  PHYS.ORG · 4 weeks
The cell polarity protein Par3 controls mechanical changes in the skin and plays an important role in cell division. Malfunction can lead to DNA damages. The balance of... more
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