Scientists have provided an explanation of how chromosomes undergo structural changes during cell differentiation.... SCIENCE DAILY · 4 months
Single-cell transcriptional diversity is a hallmark of developmental potential  Science Magazine · 4 weeks
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation is challenging. Here, we demonstrate a simple, yet... more
Shape-morphing living composites  PHYS.ORG · 2 weeks
In a recent study published on Science Advances, L. K. Rivera-Tarazona and a research team in the departments of bioengineering and biological sciences at the University of Texas, Dallas, U.S., established a new method to explore genetic networks in the... more
Lineage tracing on transcriptional landscapes links state to fate during differentiation  Science Magazine · 4 weeks
A challenge in biology is to associate molecular differences among progenitor cells with their capacity to generate mature cell types. Here, we use expressed DNA barcodes... more
Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458  Science Magazine · 2 weeks
During endoderm formation, cell identity and tissue morphogenesis are tightly controlled by cell-intrinsic and cell-extrinsic factors such as biochemical and... more
New repair mechanism for DNA breaks  PHYS.ORG · 1 week
Chromosomal breaks are the most harmful damage for cells. If they are not repaired, they block the duplication and segregation of chromosomes, stop the growth cycle and cause cell death. These breaks appear frequently in tumor... more
New mechanism for repair of chromosomal breaks  NEWS MEDICAL · 1 week
Chromosomal breaks are the most harmful damage for cells. If they are not repaired, they block the duplication and segregation of chromosomes, stop the growth cycle and cause cell death. These breaks appear frequently... more
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation  Science Magazine · 4 weeks
T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high-affinity, isotype-switched antibodies. In a... more
Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates  Science Magazine · 6 days
Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion.... more
Study uncovers how common stomach bacterium maintains its corkscrew-like shape  NEWS MEDICAL · 4 weeks
A new study shows how a common stomach bacterium is able to keep its corkscrew-like shape as it grows. Disrupting the shape could point the way for future,... more
X-ray microscopy at BESSY II: Nanoparticles can change cells  PHYS.ORG · 6 days
Nanoparticles easily enter into cells. New insights about how they are distributed and what they do there are shown for the first time by high-resolution 3D microscopy images from BESSY... more
Revolutionary reversible 4D printing with research collaborators  SCIENCE DAILY · 3 weeks
Researchers worked to revolutionize 4D printing by making a 3D fabricated material change its shape and back again repeatedly without electrical components. more
Researchers develop revolutionary reversible 4D printing  nanowerk · 3 weeks
Researchers revolutionise 4D printing by making a 3D fabricated material change its shape and back again repeatedly without electrical components. more
ZGLP1 is a determinant for the oogenic fate in mice  Science Magazine · 5 days
Mammalian sexual reproduction relies on the dichotomy of male and female germ cell development. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional... more
X-ray microscopy at BESSY II: Nanoparticles can change cells  SCIENCE DAILY · 6 days
Nanoparticles easily enter into cells. New insights about how they are distributed and what they do there are shown for the first time by high-resolution 3D microscopy images from BESSY... more
Superfast insights into cellular events  PHYS.ORG · 3 weeks
In the same way that a single piece of a puzzle fits into the whole, the molecule hypoxanthine binds to a ribonucleic acid (RNA) chain, which then changes its three-dimensional shape within a second and in so doing... more
New insight into genomic alterations associated with telomere maintenance mechanisms in cancer  NEWS MEDICAL · 2 weeks
To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. They achieve this in various different... more
Single-cell morphology encodes metastatic potential  Science Magazine · 4 weeks
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and,... more
Mathematical model reveals behavior of cellular enzymes  PHYS.ORG · 5 days
Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton University have... more
Caught soap-handed: Understanding how soap molecules help proteins get in and out of shape  PHYS.ORG · 2 weeks
Understanding the interactions between proteins and soap molecules (surfactants) has long been important for the industry, particularly within detergents and... more
Caught soap-handed: Understanding how soap molecules help proteins get in and out of shape  SCIENCE DAILY · 2 weeks
Controlling protein structure is crucial in the production of detergents and cosmetics. Up to now we have not had a... more
Researchers study how structural variations in the genome can lead to cancer  NEWS MEDICAL · 2 weeks
Structural variations in genomes can arise from deleting, amplifying, or reordering genomic segments ranging from a few thousand letters of the genetic code to... more
Detailed maps of breast cancer reveal how genetic changes shape the tumor landscape  NEWS MEDICAL · 21 hours
Scientists have created one of the most detailed maps of breast cancer ever achieved, revealing how genetic changes shape the physical tumor... more
Herringbone pattern in plant cell walls critical to cell growth  SCIENCE DAILY · 2 weeks
Plant cells tend to grow longer instead of wider due to the alignment of the many layers of cellulose that make up their cell walls, according to a... more
A tensile ring drives tissue flows to shape the gastrulating amniote embryo  Science Magazine · 4 weeks
Tissue morphogenesis is driven by local cellular deformations that are powered by contractile actomyosin networks. How localized forces are transmitted across tissues to shape... more
The latest in climate change attribution and the law  PHYS.ORG · 1 week
The evolving field of climate change attribution science plays a critical role in shaping our understanding of how humans are affecting the global climate system, and in informing discussions about... more
Universal SMP gripper with massive and selective capabilities for multiscaled, arbitrarily shaped objects  Science Magazine · 4 days
Grippers are widely used for the gripping, manipulation, and assembly of objects with a wide range of scales, shapes, and quantities in... more
Herringbone pattern in plant cell walls critical to cell growth  PHYS.ORG · 2 weeks
Plant cells tend to grow longer instead of wider due to the alignment of the many layers of cellulose that make up their cell walls, according to a... more
Researchers reveal new activity above the surface in brain-cell receptors  NEWS MEDICAL · 2 weeks
Like buoys bobbing on the ocean, many receptors float on the surface of a cell's membrane with a part sticking above the water and another underwater, inside the... more
New tool probes gene regulation  PHYS.ORG · 2 weeks
DNA methylation (DNAme) is a modification of the genome—an epigenetic "mark"—that is required for proper cellular differentiation. It has been implicated in the regulation of gene expression, but its role in this stepwise process is poorly understood. more
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