For older patients with acute myeloid leukemia, the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute and other research centers will report today at the 61st American Society of Hematology (ASH) Annual Meeting.... NEWS MEDICAL · 2 months
Harmful genetic mutations in healthy donors' stem cells may create problems in AML patients  NEWS MEDICAL · 6 days
A stem cell transplant - also called a bone marrow transplant - is a common treatment for blood cancers, such... more
Single-cell morphology encodes metastatic potential  Science Magazine · 4 hours
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and,... more
Mutations in donors' stem cells may cause problems for cancer patients  SCIENCE DAILY · 6 days
A new study suggests that extremely rare, harmful genetic mutations present in healthy donors' stem cells -- though not causing health problems in the donors --... more
InDepth Pharmaceuticals to commercialize novel technique to predict kidney transplant success  NEWS MEDICAL · 1 week
InDepth Pharmaceuticals, founded by Deepak Nihalani, Ph.D., the SmartState Endowed Chair in Renal Disease Biomarkers at the Medical University of South Carolina, has taken a vital... more
Biomaterial-based vaccine has potential to completely eliminate AML cells  NEWS MEDICAL · 1 week
Acute myeloid leukemia (AML) is a deadly blood cancer that originates in the bone marrow and kills most of its victims within five years. Chemotherapy has been the standard AML... more
Radical procedures to treat oral infections are not necessary before stem cell transplantation  NEWS MEDICAL · 3 weeks
A recently published study indicates that oral infections seem to have no association with the risk of stem cell transplantation patients dying... more
ISSCR statement on ethical standards for stem cell-based embryo models  PHYS.ORG · 6 days
The ISSCR is updating its Guidelines for Stem Cell Research and Clinical Translation to respond to recent scientific advances that include the use of pluripotent stem cell (PSC)... more
Lung microbiome of critically ill patients is predictive of clinical outcomes  NEWS MEDICAL · 23 hours
Changes in the lung microbiome may help predict how well critically ill patients will respond to care, according to new research published online in the American... more
Rejuvenating the brain with stem cells  SCIENCE DAILY · 2 weeks
The older we get the more our brains will find it difficult to learn and remember new things. The research group used a method to stimulate the small pool of neural stem cells that reside in... more
A simple twist of cell fate  PHYS.ORG · 1 week
How do a couple of universally expressed proteins in stem cells and developing embryos influence an individual cell's ultimate fate—whether it ultimately becomes, for example, a retinal cell, a heart muscle cell, or a stomach lining... more
Artificial muscle sheets transform stem cells into bone  SCIENCE DAILY · 1 week
Specifically programmed materials can, under specific conditions, encourage stem cells to transform into bone cells. To do this, scientists implemented a so-called shape-memory polymer in stem cell research. more
Clinical trial tests experimental stem cell treatment against best available drugs for MS  NEWS MEDICAL · 2 weeks
A clinical trial has begun testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing... more
New method uses MRI, machine learning to forecast genetic mutations in glioma tumors  NEWS MEDICAL · 2 weeks
Researchers at Osaka University have developed a computer method that uses magnetic resonance imaging (MRI) and machine learning to rapidly forecast genetic... more
Mediterranean diet may help protect transplant recipients' kidney health  NEWS MEDICAL · 3 weeks
A new study indicates that following the Mediterranean diet may help kidney transplant recipients maintain transplant kidney function. The findings appear in an upcoming issue of CJASN. more
Cheap drug may alleviate treatment-resistance in leukemia  SCIENCE DAILY · 5 days
A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. The researchers will now launch a... more
Scientists create 3D images of unique RNA molecule critical for stem cell programming  NEWS MEDICAL · 2 weeks
Scientists at Los Alamos and international partners have created the first 3-D images of a special type of RNA molecule that is... more
3D atlas of bone marrow -- in single cell resolution  SCIENCE DAILY · 1 month
Stem cells located in the bone marrow generate and control the production of blood and immune cells. Researchers have now developed new methods to reveal the three-dimensional organization... more
Innovative method delivers new insights into the stem cell microenvironment  PHYS.ORG · 1 month
Researchers from the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Center (DKFZ) in Heidelberg, Germany, have developed new methods to reveal the three-dimensional organization of... more
Common cardiac blood test before surgery can predict post-operative complications  NEWS MEDICAL · 4 weeks
A common cardiac blood test done before surgery can predict who will experience adverse outcomes after most types of surgery, says an international study led by Hamilton researchers. more
Effort To Control Opioids In An ER Leaves Some Sickle Cell Patients In Pain  NPR · 3 weeks
People with sickle cell disease aren't fueling the opioid crisis, research shows. Yet some ER doctors still treat patients seeking... more
New genetic test to predict and prevent vision loss from glaucoma  NEWS MEDICAL · 1 day
Researchers have identified 107 genes that increase a person's risk of developing the eye disease glaucoma, and now developed a genetic test to detect those at... more
Intervention for patients hospitalized with HIV improved reengagement and outcomes of care  SCIENCE DAILY · 2 weeks
Providing multidisciplinary team consults for HIV patients while they are hospitalized to help address social and medical barriers reduces future infection rates and boosts... more
Multivariate patterning of human pluripotent cells reveals induced paracrine factors in kidney organoid development  PHYS.ORG · 8 hours
Bioengineers have shown great promise in creating complex multicellular kidney organoids (tiny, self-organized tissues) in the lab using pluripotent stem... more
Functional validity, role, and implications of heavy alcohol consumption genetic loci  Science Magazine · 1 week
High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K.... more
How bacteria control their cell cycle  PHYS.ORG · 3 weeks
Researchers at the Biozentrum of the University of Basel have demonstrated how bacteria coordinate cell division with the replication of their genetic material. In an interdisciplinary study they explain why the current concept of the bacterial... more
MGH surgeons perform first-of-its-kind heart transplant in New England  NEWS MEDICAL · 2 weeks
A team of surgeons and specialists at Massachusetts General Hospital is announcing an achievement in transplant surgery today, having recently performed the largest number of adult heart transplants in the... more
PCORI announces new research funding opportunities to improve patient-centered outcomes  NEWS MEDICAL · 2 weeks
Following congressional reauthorization of its funding in December 2019, the Patient-Centered Outcomes Research Institute (PCORI) began accepting new proposals for research designed to help patients and those who... more
“Hotspotting” programs have virtually no impact on patient outcomes, indicates study  NEWS MEDICAL · 2 weeks
The new health care practice of "hotspotting" -- in which providers identify very high-cost patients and attempt to reduce their medical spending while improving care --... more
Study reveals new way to predict risk of death for people with stable heart failure  NEWS MEDICAL · 3 weeks
A UCLA-led study revealed a new way to predict which patients with "stable" heart failure -; those who... more
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