A new study out of Boston's Children's Hospital has used the gene-editing tool CRISPR-Cas9 to explore the fatal genetic condition called facioscapulohumeral dystrophy (FSHD, one of the family of muscular dystrophies), and to test out the potential utility of various genes involved in this disorder. The research is published in the journal Science Translational Medicine.... NEWS MEDICAL · 6 days
[Research Articles] Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy  Science Magazine · 6 days
The emergence of CRISPR-Cas9 gene-editing technologies and genome-wide CRISPR-Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process of therapeutic... more
Model that sheds light on severe Duchenne muscular dystrophy could pave the way for new therapies  NEWS MEDICAL · 5 days
Researchers have developed an experimental model of severe Duchenne muscular dystrophy that offers insight into the... more
New Cas9 variant makes genome editing even more precise  PHYS.ORG · 4 weeks
CRISPR-Cas9 has revolutionized the field of genetics by its ability to cut DNA at defined target sites. Researchers are using the Cas9 enzyme to specifically switch off genes, or insert... more
Researchers establish new viable CRISPR-Cas12b system for plant genome engineering  PHYS.ORG · 3 weeks
In a new publication in Nature Plants, assistant professor of Plant Science at the University of Maryland Yiping Qi has established a new CRISPR genome engineering system as... more
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants  Science Magazine · 5 days
Manipulation of DNA by CRISPR-Cas enzymes requires the recognition of a protospacer adjacent motif (PAM), limiting target site recognition to a subset of sequences. To remove this constraint, we engineered variants of... more
Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain  Science Magazine · 2 weeks
A genome editing technique based on the clustered regularly interspaced short palindromic repeats (CRISPR)–associated endonuclease Cas9 enables efficient... more
Research breakthrough: Humans are not the first to repurpose CRISPR  SCIENCE DAILY · 7 days
We humans are far from the first to exploit the benefits of CRISPR. Groundbreaking research has helped to redefine what CRISPR is. Researchers have discovered that primitive bacterial... more
New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus  nanowerk · 2 weeks
New genetic screening platform using CRISPR technology for targeting thousands of genes in a massively-parallel fashion; accurate and fast method of finding... more
Biomimetic human small muscular pulmonary arteries  Science Magazine · 6 days
Changes in structure and function of small muscular arteries play a major role in the pathophysiology of pulmonary hypertension, a burgeoning public health challenge. Improved anatomically mimetic in vitro models of these microvessels are urgently needed... more
Humans are not the first to repurpose CRISPR  PHYS.ORG · 7 days
In recent years, the development of CRISPR technologies and gene-editing scissors in particular have taken the world by storm. Indeed, scientists have learned how to harness these clever natural systems in the... more
Humans are not the first to exploit benefits of CRISPR technique, research shows  NEWS MEDICAL · 7 days
In recent years, the development of CRISPR technologies and gene-editing scissors in particular have taken the world by storm. Indeed, scientists have... more
Doctors try 1st CRISPR editing in the body for blindness  ABC NEWS · 4 weeks
Scientists say they have used the gene editing tool CRISPR inside someone's body for the first time more
Researchers develop new kind of CRISPR screen technology to target RNA  NEWS MEDICAL · 2 weeks
CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases. more
New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus  PHYS.ORG · 2 weeks
CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many... more
CRISPR-Cas system can be used to effectively target colitis pathogen  NEWS MEDICAL · 3 weeks
Research at North Carolina State University shows that the CRISPR-Cas system can be used to effectively target and eliminate specific gut bacteria, in this case Clostridioides difficile, the... more
Trials of potential coronavirus treatments start for some existing drugs  REUTERS · 2 weeks
Drugs used for treating arthritis are being tested as treatments for COVID-19, the disease caused by... more
New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus  SCIENCE DAILY · 2 weeks
Researchers have developed a new kind of CRISPR screen technology to target RNA. The team leveraged their technology for a critical analysis:... more
Treatments for COVID-19: Drugs being tested against the coronavirus  LIVE SCIENCE · 1 week
Here, we take a look at several of the treatments that doctors hope will help fight COVID-19, the disease caused by the novel coronavirus. more
DSI alumni use computational design to quickly discover treatments for COVID-19  NEWS MEDICAL · 1 week
Two graduates of the Data Science Institute at Columbia University are using computational design to quickly discover treatments for the coronavirus. more
Trump focuses attention on possible coronavirus treatments  ABC NEWS · 2 weeks
President Donald Trump is focusing attention on possible treatments for the new coronavirus more
CRISPR-HOT: A new tool to 'color' specific genes and cells  SCIENCE DAILY · 4 weeks
Researchers have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate how hepatocytes... more
CRISPR-HOT: A new tool to 'color' specific genes and cells  PHYS.ORG · 4 weeks
Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They... more
Researchers working on simple, low-cost CRISPR-based diagnostic test for infectious diseases  PHYS.ORG · 4 days
Researchers in the Department of Biomedical Engineering— a shared department in the schools of Dental Medicine, Medicine, and Engineering—have been working to develop a new, low-cost,... more
First patients enrolled in new clinical trial to evaluate potential COVID-19 treatments  NEWS MEDICAL · 1 week
Researchers from the University of Oxford have launched a new clinical trial to test the effects of potential drug treatments for patients admitted to... more
Treatments for rare diseases affecting children are increasing, study suggests  NEWS MEDICAL · 4 weeks
The number of treatments for rare diseases affecting children has increased, a new study suggests. But federal incentives intended to encourage drug development for rare conditions are being... more
Research may pave the way to developing effective treatments for puerperal sepsis  NEWS MEDICAL · 2 weeks
Puerperal sepsis, also known as childbed fever, is the leading cause of maternal deaths. In this novel study in The American Journal of Pathology,... more
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs  Science Magazine · 4 weeks
The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of populations with CRISPR homing gene drives. One proposed... more
Cleaving through the heart of viral infections  PHYS.ORG · 2 weeks
A novel CRISPR/Cas system that can efficiently attack and destroy several prolific plant viruses has been developed by KAUST using tobacco plants and is now being extended to rice and other crops. more
Improved CRISPR gene drive solves problems of old tech  PHYS.ORG · 4 weeks
Gene drives use genetic engineering to create a desired mutation in a few individuals that then spreads via mating throughout a population in fewer than 10 generations. more
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