Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance, virulence, and other traits among bacterial populations. The environmental and genetic forces that drive plasmid transfer are poorly understood, however, due to the lack of definitive quantification coupled with genomic analysis. Here, we integrate conjugative phenotype with plasmid genotype to provide quantitative analysis of HGT in clinical Escherichia coli pathogens. We find a substantial proportion... Science Magazine · 1 month
Stochastic transcriptional pulses orchestrate flagellar biosynthesis in Escherichia coli  Science Magazine · 3 weeks
The classic picture of flagellum biosynthesis in Escherichia coli, inferred from population measurements, depicts a deterministic program where promoters are sequentially up-regulated and are maintained steadily active throughout exponential growth.... more
Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter  Science Magazine · 3 weeks
To fight for essential metal ions, human pathogens secrete virulence-associated siderophores and retake the metal-chelated siderophores through a subfamily of adenosine triphosphate (ATP)–binding cassette (ABC) importer,... more
New laser-driven technology to detect toxins and pathogenic E. coli in food samples  NEWS MEDICAL · 1 week
Researchers at Purdue University have been working to develop new technologies to help stop the spread of foodborne illnesses, which kill 3,000... more
New laser-driven technology o detect toxins and pathogenic E. coli in food samples  NEWS MEDICAL · 1 week
Researchers at Purdue University have been working to develop new technologies to help stop the spread of foodborne illnesses, which kill 3,000... more
High mobility in a van der Waals layered antiferromagnetic metal  Science Magazine · 3 weeks
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New technology for pathogen detection driven by lasers  PHYS.ORG · 2 weeks
Researchers at Purdue University have been working to develop new technologies to help stop the spread of foodborne illnesses, which kill 3,000 people a year, by detecting them more efficiently. They have... more
Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism  Science Magazine · 2 hours
Cytostasis is the most salient manifestation of the potent antimicrobial activity of nitric oxide (NO), yet the mechanism by which NO disrupts bacterial cell division is unknown. Here, we show... more
A host's genes likely influence the spread of antibiotic resistance  SCIENCE DAILY · 4 weeks
New findings in mSphere suggest that the genetic makeup of the host organism can influence the transfer of plasmids. By identifying the host factors that facilitate or stop... more
UMass Amherst study aims to develop new test for BRCA-positive lactating moms  NEWS MEDICAL · 3 weeks
Breastfeeding women with a pathogenic BRCA1 or BRCA2 genetic mutation face a significant risk, even at a young age, of breast and ovarian cancer. more
Portable device lights the way to better foodborne illness detection  PHYS.ORG · 3 weeks
Foodborne illness hits about one in six people in the United States every year. The Centers for Disease Control and Prevention estimates that 48 million people in the... more
Portable device paves way for better detection of foodborne illness  NEWS MEDICAL · 3 weeks
Foodborne illness hits about one in six people in the United States every year. The Centers for Disease Control and Prevention estimates that 48 million people in the... more
Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection  Science Magazine · 1 week
Mucosal-associated invariant T (MAIT) cells in HIV-1–infected individuals are functionally impaired by poorly understood mechanisms. Single-cell... more
Comparing DNA-repair gene mutations in African American and Caucasian men with prostate cancer  NEWS MEDICAL · 3 weeks
Pathogenic or likely pathogenic alterations in these 14 DNA repair genes were less likely to be detected in African Americans as compared... more
Study: 25% of pathogenic bacteria can spread antibiotic resistance directly to peers  NEWS MEDICAL · 4 weeks
Biomedical engineers at Duke University have demonstrated that at least 25 percent of antibiotic-resistant pathogenic bacteria found in clinical settings are capable of spreading... more
Economic growth and environmental sustainability  PHYS.ORG · 1 month
There are political and business leaders who do not care if economic growth causes environmental damage, and there are environmental advocates who do not believe you can have economic growth without causing environmental damage. In a New York... more
SDOH screening not enough to identify patients at risk of utility shut-off  NEWS MEDICAL · 2 days
Researchers at Boston Medical Center have found that only a fraction of patients at risk of having their utilities shut off were identified through... more
New material has highest electron mobility among known layered magnetic materials  PHYS.ORG · 2 weeks
All the elements are there to begin with, so to speak; it's just a matter of figuring out what they are capable of—alone or together. For... more
Ancient DNA analysis provides insight into genetic history of Sardinia  NEWS MEDICAL · 2 days
A new study of the genetic history of Sardinia, a Mediterranean island off the western coast of Italy, tells how genetic ancestry on the island was relatively stable... more
Marine bacteria genes can help track environmental changes caused by humans  NEWS MEDICAL · 2 weeks
The gene expression of marine bacteria can be a valuable sensor for discovering environmental changes caused by humans. Furthermore, bacteria help to clean our oceans and... more
Bacteria genes help researchers keep track of human environmental impact in oceans  PHYS.ORG · 2 weeks
The gene expression of marine bacteria can be a valuable sensor for discovering environmental changes caused by humans. Furthermore, bacteria help to clean our... more
Ancient DNA from Sardinia reveals 6,000 years of genetic history  PHYS.ORG · 2 days
A new study of the genetic history of Sardinia, a Mediterranean island off the western coast of Italy, tells how genetic ancestry on the island was relatively stable... more
New world map of fish genetic diversity  PHYS.ORG · 2 weeks
An international research team from ETH Zurich and French universities has studied genetic diversity among fish around the world for the first time. Their research produced a map that will serve as a tool... more
New world map of fish genetic diversity  SCIENCE DAILY · 2 weeks
An international research team has studied genetic diversity among fish around the world for the first time. Their research produced a map that will serve as a tool in improving the protection of species... more
Hiden achieve benchmark environmental accreditation  NEWS MEDICAL · 3 weeks
Hiden Isochema is proud to announce that it has been awarded ISO 14001 accreditation for its environmental management system. more
Antibiotic-resistance in Tanzania is an environmental problem  SCIENCE DAILY · 4 weeks
WSU study finds that environmental transmission rather than antibiotic use explains the presence of antibiotic-resistant bacteria in people, domestic animals and wildlife. more
Environmental solutions to go global  PHYS.ORG · 1 week
New Australian technology that could fix some of the world's biggest environmental pollution problems—oil spills, mercury pollution and fertiliser runoff—will soon be available to global markets following the signing of a landmark partnership with Flinders University. more
Biological toolkit for composing genetic programs in mammalian cells  SCIENCE DAILY · 3 weeks
A new ensemble of parts for mammalian synthetic biology will enable the design and construction of genetic programs not previously possible. more
Social determinant screening not enough to capture patients at risk of utility shut-off  SCIENCE DAILY · 2 days
Researchers have found that only a fraction of patients at risk of having their utilities shut off were identified through social determinants... more
How cells respond appropriately in harsh environments arising from global warming  PHYS.ORG · 3 weeks
Under severe environmental stresses such as high temperature, dryness and high salinity, cells survive by responding appropriately through elaborate mechanisms, according to new cell biology research... more
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