Many of the world's most common or deadly human pathogens are RNA-based viruses—Ebola, Zika and flu, for example—and most have no FDA-approved treatments. A team led by researchers at the Broad Institute of MIT and Harvard has now turned a CRISPR RNA-cutting enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.... PHYS.ORG · 6 days
CRISPR enzyme programmed to kill viruses in human cells  SCIENCE DAILY · 6 days
Researchers have now turned a CRISPR RNA-cutting enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells. more
CRISPR RNA-cutting enzyme programmed to destroy viruses in human cells  NEWS MEDICAL · 6 days
Many of the world's most common or deadly human pathogens are RNA-based viruses -- Ebola, Zika and flu, for example -- and most have no FDA-approved treatments. more
AAV vector integration into CRISPR-induced DNA breaks  PHYS.ORG · 1 day
To design safe clinical trials, it is crucial to better understand and predict gene editing outcomes in preclinical studies. Bence György and collaborators have shown that adeno-associated viruses (AAVs) can stably integrate into CRISPR-Cas9-induced... more
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New CRISPR class expands genetic engineering toolbox  SCIENCE DAILY · 3 weeks
Biomedical engineers have used a previously unexplored CRISPR technology to accurately regulate and edit target genes in human cells. With this new approach, the researchers hope to dramatically expand the CRISPR-based tools available to... more
Engineered viruses could fight drug resistance  PHYS.ORG · 2 weeks
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Stopping cold viruses dead by blocking replication  NEWS MEDICAL · 4 weeks
The common cold virus (and its more deadly cousins, the viruses that cause polio and acute flaccid myelitis) may just have met its nemesis. In a recent study published in the journal Nature Microbiology... more
New study discovers the three-dimensional structure of the genome replication machine  PHYS.ORG · 2 weeks
Mount Sinai researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next.... more
CRISPR-BEST prevents genome instability  SCIENCE DAILY · 1 week
Scientists have developed CRISPR-BEST, a new genome editing tool for actinomycetes. It addresses the problem of genome instability caused by DNA double-stranded breaks in current CRISPR-technologies. more
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A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis  Science Magazine · 2 weeks
Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization,... more
Why multipartite viruses infect plants rather than animals  PHYS.ORG · 2 weeks
Neither living nor non-living, viruses are generally strange. Among viruses, multipartite viruses are among the most peculiar—their genome is not packed into many particles rather than one. Multipartite viruses primarily infect plants... more
Combination of two drugs disrupts cancer cells' ability to survive DNA damage, study finds  NEWS MEDICAL · 2 days
In continuing efforts to find novel ways to kill cancer cells, researchers at the University of Maryland School of Medicine... more
Researchers identify an unexpected genetic plasticity in bat-borne influenza viruses  NEWS MEDICAL · 4 weeks
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Why viruses like Herpes and Zika will need to be reclassified: Biotech impact  SCIENCE DAILY · 3 weeks
New findings reveal many different structural models for viruses, which can eventually lead to developing more targeted antiviral vaccines, by improving our... more
Why viruses like Herpes and Zika will need to be reclassified, and its biotech impact  SCIENCE DAILY · 3 weeks
New findings reveal many different structural models for viruses, which can eventually lead to developing more targeted antiviral... more
CRISPR helps find difficult to detect cancer cells  NEWS MEDICAL · 1 day
Immunotherapy is one of the latest and most effective armaments against various types of cancers. Some of the immunotherapy drugs such as PD-1 inhibitor Keytruda from Merck can block certain proteins in... more
Viruses as modulators of interactions in marine ecosystems  SCIENCE DAILY · 3 weeks
Viruses are mainly known as pathogens - often causing death. However, scientists are now showing how viruses influence the biology of living marine predators. This sheds new light on the general role... more
Engineered T cells may be harnessed to kill solid tumor cells  SCIENCE DAILY · 2 weeks
A new study finds that a form of immunotherapy used to treat the blood cancer leukemia may be effective in treating other kinds of cancer as... more
Mount Sinai researchers discover how DNA polymerase delta duplicates the genome  NEWS MEDICAL · 2 weeks
Mount Sinai researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next.... more
New study identifies potential enzyme target for diabetic retinopathy  NEWS MEDICAL · 3 weeks
A new study shows that diabetic retinopathy (DR), or retinal disease caused by the high blood glucose levels in diabetes mellitus, is due to the death of retinal cells because... more
Researchers deploy bacteriophages to fight against antibiotic resistance  NEWS MEDICAL · 2 weeks
In the battle against antibiotic resistance, many scientists have been trying to deploy naturally occurring viruses called bacteriophages that can infect and kill bacteria. more
First video of viruses assembling released  PHYS.ORG · 2 weeks
For the first time, researchers have captured images of the formation of individual viruses, offering a real-time view into the kinetics of viral assembly. The research provides new insights into how to fight viruses and engineer... more
Rare view into the formation of viruses  SCIENCE DAILY · 2 weeks
For the first time, researchers have captured images of the formation of individual viruses, offering a real-time view into the kinetics of viral assembly. The research provides new insights into how to fight viruses... more
First video of viruses assembling (w/video)  nanowerk · 1 week
For the first time, researchers have captured images of the formation of individual viruses, offering a real-time view into the kinetics of viral assembly. The research provides new insights into how to fight viruses and engineer... more
Researchers unlock potential to use CRISPR to alter the microbiome  SCIENCE DAILY · 2 weeks
Researchers have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on specific... more
Researchers unlock potential to use CRISPR to alter the microbiome  PHYS.ORG · 2 weeks
Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted... more
Targeting specific enzyme could combat Alzheimer’s disease on two fronts  NEWS MEDICAL · 4 weeks
UQ researchers have discovered a potential drug target for Alzheimer’s disease — an enzyme which has effects on both the immune and nervous systems. more
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