A recent article studies chitin-binding proteins from a soilborne fungus (Verticillium nonalfalfae) that causes vascular wilt in plants. This fungus binds a particular protein (VnaChtBP) to chitin in order to abolish the host plant's chitin-triggered burst of reactive oxygen species and shield the fungus from being digested by the plant.... SCIENCE DAILY · 1 month
Discovery of a new protein gives insight into a long-standing plant immunity mystery  PHYS.ORG · 1 week
When a plant senses an invading pathogen, it activates a molecular signaling cascade that switch on its defense mechanisms. One such mechanism... more
'Dual login' mechanism found to resist fungal infection in cells  PHYS.ORG · 4 weeks
Indiana University researchers have identified a mechanism involving the body's ability to resist fungal infection. The work could help advance research on cancer therapies that use the body's... more
Researchers identify new mechanism to resist fungal infection in cells  NEWS MEDICAL · 4 weeks
Indiana University researchers have identified a mechanism involving the body's ability to resist fungal infection. The work could help advance research on cancer therapies that use the body's... more
Current treatment for fungal meningitis is fueling drug resistance  SCIENCE DAILY · 1 week
A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new research warns. The findings highlight the need to develop... more
Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation  Science Magazine · 3 weeks
The pleiotropic host resistance factor SLC11A1 (NRAMP1) defends against diverse intracellular pathogens in mammals by yet-unknown mechanisms. We compared Salmonella infection of coisogenic mice with different SLC11A1 alleles.... more
Host cell proteases can process viral capsid proteins  PHYS.ORG · 1 week
It has long been suggested that a cell protease could take part in enterovirus infection. However, the identities of such proteases have remained unknown. The work performed in the University of Jyväskylä... more
Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection  Science Magazine · 3 weeks
Increasing evidence indicates that infection-triggered host defenses are regulated by the nervous system. However, the precise mechanisms of this regulation are not well understood. Here, we demonstrate that... more
Researchers develop a database to aid in identifying key genes for bacterial infections  PHYS.ORG · 4 weeks
Infectious diseases are caused by pathogenic microorganisms capable of entering, colonizing and growing within a host organism, thus producing an infection. Bacterial... more
Genetic typing of a bacterium with biotechnological potential  PHYS.ORG · 1 week
Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p.—the ability of the bacterium to infect its host and inflict a disease—is considered to... more
Kanazawa University researchers describe genetic typing of Pseudomonas putida  NEWS MEDICAL · 1 week
Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p. -- the ability of the bacterium to infect its host and inflict... more
Novel way to ID disease-resistance genes in chocolate-producing trees found  PHYS.ORG · 1 week
Chocolate-producing cacao trees that are resistant to a major pathogen were identified by an international team of plant geneticists. The findings point the way for plant breeders to... more
Novel way to ID disease-resistance genes in chocolate-producing trees found  SCIENCE DAILY · 1 week
Chocolate-producing cacao trees that are resistant to a major pathogen were identified by an international team of plant geneticists. The findings point the way for plant breeders to... more
Self-assembling system uses magnets to mimic specific binding in DNA  nanowerk · 3 weeks
Researchers are using the binding power of magnets to design self-assembling systems that potentially can be created in nanoscale form. more
Self-assembling system uses magnets to mimic specific binding in DNA  SCIENCE DAILY · 3 weeks
Physicists are using the binding power of magnets to design self-assembling systems that potentially can be created in nanoscale form. more
Quantum mechanics of proteins in explicit water: The role of plasmon-like solute-solvent interactions  Science Magazine · 1 day
Quantum-mechanical van der Waals dispersion interactions play an essential role in intraprotein and protein-water interactions—the two main factors affecting the structure and... more
A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species  Science Magazine · 2 weeks
While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to... more
Researchers uncover the binding mechanism of opioid receptor  NEWS MEDICAL · 2 weeks
Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor. more
Ketogenic diet activates protective {gamma}{delta} T cell responses against influenza virus infection  Science Magazine · 4 weeks
Influenza A virus (IAV) infection–associated morbidity and mortality are a key global health care concern, necessitating the identification of new therapies capable of reducing... more
How to find molecular glues to effectively target diseases  PHYS.ORG · 2 weeks
Many of the currently available drugs are not specific enough to effectively cure complex diseases such as cancer, neurodegenerative diseases and diabetes. In addition, drug resistance reduces the effectiveness of... more
Depletion of microbiome-derived molecules in the host using Clostridium genetics  Science Magazine · 2 days
The gut microbiota produce hundreds of molecules that are present at high concentrations in the host circulation. Unraveling the contribution of each molecule to host biology remains difficult.... more
Host cell calpain proteases can process enterovirus polyprotein in vitro, study shows  NEWS MEDICAL · 1 week
It has long been suggested that a cell protease could take part in enterovirus infection. However, the identity of such proteases have remained unknown. more
Dangerous bacteria send out warning signals when attacked by antibiotics  NEWS MEDICAL · 3 weeks
A bacterial infection is not just an unpleasant experience - it can also be a major health problem. Some bacteria develop resistance to otherwise effective treatment with antibiotics. more
Yeasts derived from food can reduce multi-drug resistant fungal infections  NEWS MEDICAL · 4 days
A study by researchers in the United States and India has shown that probiotic yeasts derived from food are able to reduce the virulence of, and even prevent... more
Pot while pregnant: Doctors urge caution  SCIENCE DAILY · 2 weeks
Daily marijuana use during pregnancy may lead to an increased risk of low birth weight, low resistance to infection, decreased oxygen levels and other negative fetal health outcomes, according to a new study. more
Attacking HIV at the source  NEWS MEDICAL · 3 weeks
A new study published on November 26, 2019, in the journal Cell Reports, details a new discovery that may help avert HIV infection right at the start. The virus is known to take a long time to infect... more
Dynamics of crucial immune system proteins  SCIENCE DAILY · 2 weeks
Of the many marvels of the human immune system, the processing of antigens by the class I proteins of the major histocompatability complex (MHC-I) is among the most mind-boggling. Exactly how these proteins carry out their... more
New database helps identify therapeutic targets to fight infectious diseases  NEWS MEDICAL · 4 weeks
Infectious diseases are caused by pathogenic microorganisms capable of entering, colonizing and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise... more
Study reveals dynamics of crucial immune system proteins  PHYS.ORG · 2 weeks
Of the many marvels of the human immune system, the processing of antigens by the class I proteins of the major histocompatability complex (MHC-I) is among the most mind-boggling. Exactly how these... more
Computational design of a modular protein sense-response system  Science Magazine · 3 weeks
Sensing and responding to signals is a fundamental ability of living systems, but despite substantial progress in the computational design of new protein structures, there is no general approach for engineering arbitrary... more
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