Microbiology
Researchers find high-risk genes for schizophrenia  SCIENCE DAILY · 6 hours
Using a unique computational 'framework' they developed, a team of scientist cyber-sleuths has identified 104 high-risk genes for schizophrenia. more
Overlooked molecular machine in cell nucleus may hold key to treating aggressive leukemia  SCIENCE DAILY · 6 hours
Many people fighting a very aggressive form of acute myeloid leukemia (AML) don't survive more than five years. These very sick patients... more
Protecting damaged hearts with microRNAs  SCIENCE DAILY · 8 hours
Once the heart is formed, its muscle cells have very limited ability to regenerate. After a heart attack, these cells die off and scar tissue forms, potentially setting people up for heart failure. A new study advances the... more
New genomics tool ECCITE-seq expands multimodal single cell analysis  SCIENCE DAILY · 8 hours
ECCITE-seq (Expanded CRISPR-compatible Cellular Indexing of Transcriptomes and Epitopes by sequencing) allows researchers to perform high-throughput measurements of multiple modalities of information from single cells. The technique profiles different types... more
Advance in CAR T-cell therapy eliminates severe side effects  SCIENCE DAILY · 8 hours
An advance in the cancer treatment known as CAR T-cell therapy appears to eliminate its severe side effects, making the treatment safer and potentially available in outpatient settings. more
Droplet trains reveal how nature navigates blood traffic  SCIENCE DAILY · 8 hours
Scientists report that they discovered spontaneous oscillations in microfluidic droplet networks. The scientists have successfully modeled network channels similar to our blood capillaries in the simplest way containing one or two loops.... more
Heterogeneous catalyst goes enzymatic  SCIENCE DAILY · 8 hours
Researchers demonstrated enzyme-like heterogeneous catalysis for the first time. They developed a highly active heterogeneous TiO2 photocatalyst incorporated with many single copper atoms. They used this catalyst for the photocatalytic hydrogen production, and found that the catalyst is as active... more
New genomics tool ECCITE-seq expands multimodal single cell analysis  PHYS.ORG · 9 hours
A new technique called ECCITE-seq, developed by scientists at the New York Genome Center's (NYGC) Technology Innovation Lab (@NYGCtech), allows researchers to perform high-throughput measurements of multiple modalities of information... more
Advance in breakthrough cancer treatment eliminates serious side effects  NEWS MEDICAL · 10 hours
An advance in the breakthrough cancer treatment known as CAR T-cell therapy appears to eliminate its severe side effects, making the treatment safer and potentially available in outpatient settings, a... more
Overlooked part of cell’s internal machinery may hold key to treating acute myeloid leukemia  NEWS MEDICAL · 10 hours
Many individuals forced to fight an exceptionally aggressive form of the blood cancer acute myeloid leukemia (AML) don't survive more... more
Hole-forming protein could help control cancer growth  NEWS MEDICAL · 12 hours
Sometimes cells need to die. The process of cell death is encoded within the genome of all higher organisms to kill off cancerous cells, and as a normal part of development to shape a... more
Researchers are developing brand-new method to cure brain tumors  NEWS MEDICAL · 12 hours
Scientists from Far Eastern Federal University in cooperation with colleagues from Blokhin Russian Cancer Research Center, Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway... more
Hole-forming protein may suppress tumor growth  SCIENCE DAILY · 13 hours
A gene called gasdermin E, which is downregulated in many cancers, aids cells in dying in an unexpected way, and may also suppress tumor growth. more
DNA is managed like climbers' rope to help keep tangles at bay  SCIENCE DAILY · 13 hours
Scientists have uncovered a process in cells that prevents DNA from becoming tangled, which resembles a method used to control climbers' ropes. more
Scientists identify a novel target for corn straw utilization  PHYS.ORG · 13 hours
Plant cell walls, as repositories of fixed carbon, are an important source of biomass, which is mainly composed of cellulose, hemicellulose, and lignin. However, the complex lignin structure makes it... more
Researchers make synthetic polymers inside of living cells  PHYS.ORG · 13 hours
A team of researchers at the University of Edinburgh has demonstrated that it is possible to create synthetic polymers inside of living cells. In their paper published in the journal Nature Chemistry,... more
Slime mold absorbs substances to memorize them  PHYS.ORG · 13 hours
In 2016, CNRS scientists demonstrated that the slime mold Physarum polycephalum, a single-cell organism without a nervous system, could learn to no longer fear a harmless but aversive substance and could transmit this knowledge... more
Mechanism of a protein upon infection of the 'Fasciola hepatica'  SCIENCE DAILY · 14 hours
The study also validated ten reference genes in sheep that allow for studying how the immune system behaves when facing this disease. more
DNA managed like climbing rope to avoid knots  PHYS.ORG · 14 hours
A process that cells use to unravel knotted strands of DNA – resembling a method used to control climbing ropes – has been uncovered by scientists. more
Slow charge generation plays big role in model material for solar cells  PHYS.ORG · 15 hours
Next-generation devices based on molecular materials have the potential to efficiently use sunlight to produce electricity or to drive chemical reactions. In contrast to... more
'Longevity gene' responsible for more efficient DNA repair  PHYS.ORG · 15 hours
Explorers have dreamt for centuries of a Fountain of Youth, with healing waters that rejuvenate the old and extend life indefinitely. more
Quantum-material-based proton-irradiation-immune electronics for space travel  nanowerk · 18 hours
Proton radiation damage is an important failure mechanism for electronic devices in near-Earth orbits and deep space. The future of space exploration depends crucially on the development of new electronic technologies that are immune to space... more
Deep-learning model better predicts survival outcomes for lung cancer  NEWS MEDICAL · 19 hours
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. more
Research uncovers critical RNA processing aberrations in ALS and FTD  NEWS MEDICAL · 24 hours
Research by a Barrow Neurological Center scientist on mechanisms of dysfunctional RNA processing in ALS and frontal temporal dementia was published in the April issue of Acta Neuropathologica. more
Bacteria play a role in the development of stomach ulcers in pigs  NEWS MEDICAL · 1 day
Stomach ulcers are common in pigs, like they are in humans. Until recently, the cause of this disease was unclear. more
China draws up tighter rules on human gene and embryo trials: Xinhua  REUTERS · 3 days
China's top legislature will consider tougher rules on research involving human genes and embryos, the first such move since a Chinese scientist sparked controversy... more
A universal framework combining genome annotation and undergraduate education  PHYS.ORG · 3 days
As genome sequencing becomes cheaper and faster, resulting in an exponential increase in data, the need for efficiency in predicting gene function is growing, as is the need to train... more
On-chip drug screening for identifying antibiotic interactions in eight hours  SCIENCE DAILY · 3 days
A research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening platform... more
New method to detect off-target effects of CRISPR  SCIENCE DAILY · 3 days
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in... more
A polyaromatic receptor with high androgen affinity  Science Magazine · 3 days
Biological receptors distinguish and bind steroid sex hormones, e.g., androgen-, progestogen-, and estrogen-type hormones, with high selectivity. To date, artificial molecular receptors have been unable to discriminate between these classes of biosubstrates. Here, we... more
Discovery may help explain why women get autoimmune diseases far more often than men  SCIENCE DAILY · 3 days
New evidence points to a key role for a molecular switch called VGLL3 in autoimmune diseases, and the major gap... more
A specific gene-microbe interaction drives the development of Crohns disease-like colitis in mice  Science Magazine · 3 days
Bacterial dysbiosis is associated with Crohn’s disease (CD), a chronic intestinal inflammatory disorder thought to result from an abnormal immune response against... more
Warming: Plants are also stressed out  SCIENCE DAILY · 3 days
What will a three-degree-warmer world look like? When experiencing stress or damage from various sources, plants use chloroplast-to-nucleus communication to regulate gene expression and help them cope. Now, researchers have found that GUN1 -- a gene... more
In rare cases, immune system fails despite HIV suppression  SCIENCE DAILY · 3 days
Antiretroviral therapy (ART) is usually effective at suppressing HIV, allowing the immune system to recover by preventing the virus from destroying CD4+ T cells. Scientists have now identified a rare,... more
Scientists uncover a link between RNA editing and chloroplast-to-nucleus communication  PHYS.ORG · 4 days
What will a three-degree-warmer world look like? How will plants fare in more extreme weather conditions? When experiencing stress or damage from various sources, plants use chloroplast-to-nucleus communication... more
New method to detect off-target effects of CRISPR  PHYS.ORG · 4 days
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in... more
Behavioral disorders in kids with autism linked to reduced brain connectivity  SCIENCE DAILY · 4 days
More than a quarter of children with autism spectrum disorder are also diagnosed with disruptive behavior disorders. Now researchers have identified a possible biological cause: a... more
Fuel cells in bacteria  PHYS.ORG · 4 days
The exchange of nitrogen between the atmosphere and organic matter is crucial for life on Earth because nitrogen is a major component of essential molecules such as proteins and DNA. One major route for this exchange, discovered only in the... more
On-chip drug screening for identifying antibiotic interactions in eight hours  PHYS.ORG · 4 days
A KAIST research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening... more
BRB-seq: The quick and cheaper future of RNA sequencing  PHYS.ORG · 4 days
RNA sequencing is a technique used to analyze entire genomes by looking at the expression of their genes. Today, such genome-wide expression analyses are a standard tool for genomic studies... more
Taming the genome's 'jumping' sequences  PHYS.ORG · 4 days
The human genome is fascinating. Once predicted to contain about a hundred thousand protein-coding genes, it now seems that the number is closer to twenty thousand, and maybe less. And although our genome is made up of about... more
Mysterious river dolphin helps crack the code of marine mammal communication  PHYS.ORG · 4 days
The Araguaian river dolphin of Brazil is something of a mystery. It was thought to be quite solitary, with little social structure that would require communication.... more
Multiple modes for selectivity of transmembrane transport  PHYS.ORG · 4 days
LMU researchers utilized a biophysical approach to understand how bacterial import proteins bind and selectively convey their cargoes across membranes. The results reveal an unexpectedly wide variety of transfer mechanisms. more
Researchers explore whether time of day can affect the body's response to physical exertion  NEWS MEDICAL · 4 days
Two papers appearing April 18 in the journal Cell Metabolism confirm that the circadian clock is an important factor in... more
Research sheds light on how hepatitis B virus establishes chronic infection  NEWS MEDICAL · 4 days
New research sheds light on how a hepatitis B viral protein stimulates the expansion of immune cells that impair antiviral responses, according to a study published... more
Phasefocus to launch new cell imaging system with smart incubation technology  NEWS MEDICAL · 4 days
Phasefocus has secured additional investment as it prepares to launch the newest version of its flagship live cell imaging and analysis system, Livecyte™. more
Next frontier in study of gut bacteria: mining microbial molecules  PHYS.ORG · 4 days
The human gut harbors trillions of invisible microbial inhabitants, referred to as the microbiota, that collectively produce thousands of unique small molecules. The sources and biological functions of... more
Molecular target UNC45A is essential for cancer cell proliferation and tumor growth  NEWS MEDICAL · 4 days
Identifying a protein that plays a key role in cancer cell growth is a first step toward the development of a targeted cancer therapy.... more
Specific strains of Staphylococcus aureus linked to wounds that do not heal  NEWS MEDICAL · 4 days
Whether a wound--such as a diabetic foot ulcer--heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome... more
Key proteins can block Listeria without triggering the death of host cells  NEWS MEDICAL · 4 days
New North Carolina State University research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also... more
Scientists deploy CRISPR gene-editing tool to engineer multiple edits  NEWS MEDICAL · 4 days
Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments... more
Scientists get closer to injecting artificial lymph nodes into people to fight disease  NEWS MEDICAL · 4 days
In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a... more
Molecular target UNC45A is essential for cancer but not normal cell proliferation  PHYS.ORG · 4 days
Identifying a protein that plays a key role in cancer cell growth is a first step toward the development of a targeted cancer therapy.... more
Study: Measles outbreaks may become more frequent if vaccination rates continue to decline  NEWS MEDICAL · 4 days
In 2000, measles was declared to be eliminated in the United States, when no sustained transmission of the virus was seen in... more
Scientific breakthrough provides new hope for people living with multiple sclerosis  NEWS MEDICAL · 4 days
A scientific breakthrough provides new hope for millions of people living with multiple sclerosis. Researchers at Oregon Health & Science University have developed a compound that... more
Scientists identify rare, paradoxical response to antiretroviral therapy  NEWS MEDICAL · 4 days
Antiretroviral therapy is usually very effective at suppressing HIV in the body, allowing a person's immune system to recover by preventing the virus from destroying CD4+ T cells. more
Triple negative breast cancer develop resistance to chemotherapy by turning on molecular pathway  NEWS MEDICAL · 4 days
Researchers at The University of Texas MD Anderson Cancer Center have discovered that triple negative breast cancer cells can develop resistance to... more
KZFPs play a key role in the regulation of human genome  NEWS MEDICAL · 4 days
The human genome is fascinating. Once predicted to contain about a hundred thousand protein-coding genes, it now seems that the number is closer to twenty thousand,... more
Novel system enables researchers to study bacteria within mini-tissues in a dish  NEWS MEDICAL · 4 days
Engineering bacteria to intelligently sense and respond to disease states, from infections to cancer, has become a promising focus of synthetic biology. more
New discovery transforms conventional microfluidics into open-space microfluidics  NEWS MEDICAL · 4 days
Microfluidics refers to the manipulation of fluids in microscale devices. Commonly called "labs on a chip," microfluidic systems are used to study and analyze very small-scale chemical or biological samples, replacing the... more
Two new epigenetic regulators maintain self-renewal of embryonic stem cells  NEWS MEDICAL · 4 days
Embryonic stem cells have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body. more
Study compares effectiveness and cost of gene therapy and HSCT in major beta-thalassemia  NEWS MEDICAL · 4 days
Gene therapy offers the promise of a cure for beta-thalassemia and a new study has shown that it is associated with fewer... more
Scientists use NIR light and injected DNA nanodevice to guide stem cells to injury  NEWS MEDICAL · 4 days
What if doctors had a remote control that they could use to steer a patient's own cells to a wound... more
Making digital tissue imaging better  SCIENCE DAILY · 4 days
A low-tech problem troubles the high-tech world of digital pathology imaging: There are no reliable standards for the quality of digitized tissue slides comprising the source material for computers reading and analyzing vast numbers of images. Poor-quality slides... more
RNA sequencing used to discover novel genes and pathways in celiac disease  SCIENCE DAILY · 4 days
Researchers have discovered novel genes and pathways related to early stages in the development of celiac disease and the ongoing inflammation and comorbidities associated... more
BRB-seq: The quick and cheaper future of RNA sequencing  SCIENCE DAILY · 4 days
Bioengineers have developed a new method for Bulk RNA Sequencing that combines the multiplexing-driven cost-effectiveness of a single-cell RNA-seq workflow with the performance of a bulk RNA-seq procedure. more
New eDNA technology used to quickly assess coral reefs  SCIENCE DAILY · 4 days
Scientists have developed a technique for measuring the amount of living coral on a reef by analyzing DNA in small samples of seawater. more
New automated biological-sample analysis systems to accelerate disease detection  SCIENCE DAILY · 4 days
Microfluidics refers to the manipulation of fluids in microscale devices. Commonly called "labs on a chip," microfluidic systems are used to study and analyze very small-scale chemical or biological samples,... more
Growing a cerebral tract in a microscale brain model  SCIENCE DAILY · 4 days
An international research team modeled the growth of cerebral tracts. Using neurons derived from stem cells, they grew cortical-like spheroids. In a microdevice, the spheroids extended bundles of axons toward... more
Antimicrobial paints have a blind spot  SCIENCE DAILY · 4 days
Researchers tested bacteria commonly found inside homes on samples of drywall coated with antimicrobial, synthetic latex paints. Within 24 hours, all bacteria died except for Bacillus timonensis, a spore-forming bacterium. more
Infection biology: Gut microbe helps thwart Salmonella  SCIENCE DAILY · 4 days
Researchers have identified a bacterial species in the gut microbiome of the mouse which protects against infection by human-pathogenic Salmonella. more
Scientists advance creation of 'artificial lymph node' to fight cancer, other diseases  SCIENCE DAILY · 4 days
In a proof-of-principle study in mice, scientists report the creation of a specialized gel that acts like a lymph node to successfully activate and... more
Bioengineers program cells as digital signal processors  SCIENCE DAILY · 4 days
Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells. The research dramatically expands the chemical, physical and environmental cues engineers can use to prompt programmed responses from engineered... more
How the hepatitis B virus establishes persistent infection  SCIENCE DAILY · 4 days
New research sheds light on how a hepatitis B viral protein stimulates the expansion of immune cells that impair antiviral responses. The findings potentially explain how the hepatitis B virus (HBV) establishes... more
Certain strains of bacteria associated with diabetic wounds that do not heal  SCIENCE DAILY · 4 days
Whether a wound -- such as a diabetic foot ulcer -- heals or progresses to a worse outcome, including infection or even amputation, may... more
Study shows promise in repairing damaged myelin  SCIENCE DAILY · 4 days
A new study shows that a synthetic molecule stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord. The study demonstrates in mice that a synthetic molecule called... more
What Are Stem Cells?  LIVE SCIENCE · 4 days
Embryonic stem cells can morph into any cell in the human body. more
Researchers use gene editing with CRISPR to treat lethal lung diseases before birth  SCIENCE DAILY · 4 days
Using CRISPR gene editing, researchers have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death... more
Carrier lifetimes of >1 {mu}s in Sn-Pb perovskites enable efficient all-perovskite tandem solar cells  Science Magazine · 4 days
All-perovskite-based polycrystalline thin-film tandem solar cells have the potential to deliver efficiencies of > 30%. However, the performance of all-perovskite-based... more
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses  Science Magazine · 4 days
Targeted blockade of PD-1 using checkpoint inhibitor immunotherapies can activate T cells to destroy tumors. PD-1 is believed to function... more
Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies  Science Magazine · 4 days
Eukaryotic genes are regulated by multivalent transcription factor complexes. Through cooperative self-assembly, these complexes perform non-linear regulatory operations involved in cellular decision-making and signal processing. Here,... more
Rare 'Bubble Boy Disease' Likely Cured with New Gene Therapy  LIVE SCIENCE · 4 days
Eight infants with a severe immune disorder, known as "bubble boy disease," appear to be cured of the disease thanks to an experimental gene therapy. more
Cell-killing proteins suppress listeria without killing cells  SCIENCE DAILY · 4 days
New research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells. more
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1  Science Magazine · 4 days
Malignancies arising from mutation of tumor suppressors have unexplained tissue proclivity. For example, BAP1 encodes a widely expressed deubiquitinase for histone H2A,... more
Comment on "Ghost cytometry"  Science Magazine · 4 days
Ota et al. (Reports, 15 June 2018, p. 1246) report using pseudo-random optical masks and a spatial-temporal transformation to perform blur-free, high–frame rate imaging of cells in flow with a high signal-to-noise ratio. They also claim sorting at rates of... more
Response to Comment on "Ghost cytometry"  Science Magazine · 4 days
Di Carlo et al. comment that our original results were insufficient to prove that the ghost cytometry technique is performing a morphologic analysis of cells in flow. We emphasize that the technique is primarily intended to... more
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq  Science Magazine · 4 days
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct... more
How superstitions spread  SCIENCE DAILY · 4 days
Superstitious beliefs may seem irrational, but they can nevertheless catch on in a society. Using an evolutionary approach to studying the emergence of coordinated behaviors, biologists showed how a jumble of individual beliefs, including superstitions, can coalesce into an accepted... more
Bioengineers program cells as digital signal processors  nanowerk · 4 days
Synthetic biologists add tunable, analog-to-digital converter to their toolkit. more
General anesthesia hijacks sleep circuitry to knock you out  SCIENCE DAILY · 4 days
Researchers have found that general anesthesia induces unconsciousness by hijacking the neural circuitry that makes us fall sleep. They traced this neural circuitry back to a cluster of cells at... more
To amp up solar cells, scientists ditch silicon  Science Magazine · 4 days
New perovskite tandem cell promises to be cheaper than conventional ones, and almost as efficient more
Bioengineers add cooperative molecules to their toolkit for programming signal processing  PHYS.ORG · 4 days
Elaborate molecular networks inside living cells enable them to sense and process many signals from the environment to perform desired cellular functions. Synthetic biologists have been... more
Medical News Today: Breast cancer: Reducing this amino acid could make drugs more effective  MNT · 4 days
New research in cell cultures and mice reveals a surprising link between the essential amino acid leucine and resistance to... more
A history of the Crusades, as told by crusaders' DNA  SCIENCE DAILY · 4 days
History can tell us a lot about the Crusades, the series of religious wars fought between 1095 and 1291, in which Christian invaders tried to claim the Near... more
Algae
Researchers develop new platform that recreates cancer in a dish to quickly determine the best bacterial therapy
PHYS.ORG
Dead pig brains bathed in artificial fluid showed signs of cellular life
SCIENCE-NEWS
These beetles have successfully freeloaded for 100 million years
PHYS.ORG
A new bacteria-killing weapon in the fight against antibiotic resistance
PHYS.ORG
New imaging technique reveals 'burst' of activity before cell death
PHYS.ORG
In cellular world, strong relationships the key to healing old wounds
PHYS.ORG
Cell death may be triggered by 'hit-and-run' interaction
PHYS.ORG
Cold plasma can kill 99.9% of airborne viruses, study shows
PHYS.ORG
Hearts and lung transplants from hepatitis-C infected donors considered safe
NEWS MEDICAL
Will the ocean benefit from the battle of the microbeads bans?
PHYS.ORG
Microscopic swimmers with visual perception of group members form stable swarms
PHYS.ORG
Zooming in on an inner-cell DNA repair shop
PHYS.ORG
Keeping genetic engineering localized
PHYS.ORG
Team harnesses spin of electrons to power tech devices
PHYS.ORG
Chemists design faster production process for essential sugars
PHYS.ORG
Putting the science in science communication
PHYS.ORG
Protein 'spat out' by cancer cells promotes tumor growth
SCIENCE DAILY
Here's what that house proud mouse was doing – plus five other animals who take cleaning seriously
PHYS.ORG
Fresh