Microbiology
New structure for HIV-1 viral shell proposed  NEWS MEDICAL · 8 hours
The matrix shell of the HIV-1 virus may have a different shape than previously thought, and a newly proposed model has significant implications for understanding how the virus functions, according to a new study... more
Researchers identify novel genes associated with severity of peanut allergy  NEWS MEDICAL · 12 hours
Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these... more
NIH provides up to $102.5 million in renewed funding for Antibacterial Resistance Leadership Group  NEWS MEDICAL · 13 hours
As antibiotic-resistant bacteria become more urgent threats worldwide, the National Institute of Allergy and Infectious Diseases, part of the National... more
Novel drug shows efficacy against advanced ROS1 and NTRK fusion-positive NSCLC  NEWS MEDICAL · 13 hours
Pooled analysis of three phase 1 and 2 clinical trials published online ahead of print in the journal Lancet Oncology show that the drug entrectinib is... more
Researchers make significant advances in developing novel Zika virus vaccine  NEWS MEDICAL · 14 hours
Researchers from the University of Adelaide have made significant advances in developing a novel vaccine against Zika virus, which could potentially lead to global elimination of the disease. more
Why are giant pandas born so tiny?  SCIENCE DAILY · 16 hours
Born pink, blind, and helpless, giant pandas typically weigh about 100 grams at birth -- the equivalent of a stick of butter. Their mothers are 900 times more massive than that. That raises a... more
Mitochondria are the 'canary in the coal mine' for cellular stress  SCIENCE DAILY · 16 hours
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, researchers have discovered a new function of mitochondria: they set off molecular... more
Following the lizard lung labyrinth  SCIENCE DAILY · 16 hours
Birds and mammals are on extreme ends of the airflow spectrum. Mammals inhale oxygen-rich air and they exhale depleted air, exhibiting a so-called tidal flow pattern. In contrast, bird breath travels tidally through part of the respiratory system,... more
Mitochondria are the 'canary in the coal mine' for cellular stress  PHYS.ORG · 1 day
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off... more
Punching holes in opaque solar cells turns them transparent  nanowerk · 1 day
Researchers have found an effective and inexpensive strategy to transform solar cells from opaque to transparent. more
Rectal microbes could make a difference to the effectiveness of HIV vaccines  NEWS MEDICAL · 1 day
Microbes living in the rectum could make a difference to the effectiveness of experimental HIV vaccines, according to researchers at the University of California,... more
Neuroscientists develop new method for uniquely targeted gene therapy  NEWS MEDICAL · 1 day
Neuroscientists at Lund University in Sweden have developed a new technology that engineers the shell of a virus to deliver gene therapy to the exact cell type in the body... more
Rectal microbes influence effectiveness of HIV vaccine  SCIENCE DAILY · 2 days
Microbes living in the rectum could make a difference to the effectiveness of experimental HIV vaccines, according to researchers. more
The wild relatives of major vegetables, needed for climate resilience, are in danger  PHYS.ORG · 2 days
Growing up in the wild makes plants tough. Wild plants evolve to survive the whims of nature and thrive in difficult conditions,... more
Topology-dependent anomalous dynamics of ring and linear DNA are sensitive to cytoskeleton crosslinking  Science Magazine · 2 days
Cytoskeletal crowding plays a key role in the diffusion of DNA molecules through the cell, acting as a barrier to effective intracellular... more
Synthetic nanopores made from DNA  SCIENCE DAILY · 2 days
A scientific collaboration has resulted in the construction of a synthetic DNA nanopore capable of selectively translocating protein-size macromolecules across lipid bilayers. more
Breakthrough in Zika virus vaccine  SCIENCE DAILY · 2 days
Researchers have made significant advances in developing a novel vaccine against Zika virus, which could potentially lead to global elimination of the disease. more
A self-cleaning surface that repels even the deadliest superbugs  PHYS.ORG · 2 days
A team of researchers at McMaster University has developed a self-cleaning surface that can repel all forms of bacteria, preventing the transfer of antibiotic-resistant superbugs and other dangerous bacteria in... more
Freestanding microwire-array enables flexible solar window  PHYS.ORG · 2 days
TSCs are emerging devices that combine the advantages of visible transparency and light-to-electricity conversion. One of the valuable prospective applications of such devices is their integration into buildings, vehicles, or portable electronics. Therefore, colour-perception and flexibility... more
Researchers create synthetic nanopores made from DNA  PHYS.ORG · 2 days
In 2015, the first commercial nanopore DNA sequencing device was introduced by Oxford Nanopore Technologies. Based on a synthetically engineered transmembrane protein, nanopore sequencing allows long DNA strands to be channelled through the central... more
Researchers create synthetic nanopores made from DNA  nanowerk · 2 days
Researchers have constructed a synthetic DNA nanopore capable of selectively translocating protein-size macromolecules across lipid bilayers. more
Protein injections in medicine  PHYS.ORG · 2 days
Pathogens can use a range of toxins to damage their host organism. Bacteria, such as those responsible for causing the deadly Plague, use a special injection mechanism to deliver their poisonous contents into the host cell. Stefan Raunser, Director at... more
Amid the wasteland of the Salton Sea, a miraculous but challenging oasis is born  PHYS.ORG · 2 days
It came as a bittersweet surprise to biologists and government agencies monitoring the steadily shrinking Salton Sea's slide toward death... more
Freestanding microwire-array enables flexible solar window  nanowerk · 2 days
Transparent solar cells (TSC) are emerging device that combines the benefits of visible transparency and electricity generation. Scientist have developed a new-concepted TSC consisting of freestanding Si microwire-arrays and transparent polymer matrix with tunable transparency and... more
Scientists explain why some molecules spontaneously arrange themselves into five slices of nanoscale pie  PHYS.ORG · 2 days
Materials formed on vanishingly small scales are being used in medicine, electronics, manufacturing and a host of other applications. But... more
Breast cancer cells swallow a 'free lunch' of dietary fat particles from the bloodstream  SCIENCE DAILY · 2 days
A research team has previously shown that fatty particles from the bloodstream may boost the growth of breast cancer cells.... more
Success in metabolically engineering marine algae to synthesize valuable antioxidant astaxanthin  PHYS.ORG · 2 days
A research group led by Professor HASUNUMA Tomohisa of Kobe University's Engineering Biology Research Center have succeeded in synthesizing the natural pigment astaxanthin using the fast-growing... more
Chimpanzees may have evolved resistance to HIV precursor  PHYS.ORG · 2 days
Simian immunodeficiency virus, the monkey- and ape-infecting virus that HIV originated from, may have influenced the genetics of chimpanzees, finds a new UCL-led study. more
Researchers find many psychiatric disorders share the same gene variants  NEWS MEDICAL · 2 days
An international team of researchers has found that many psychiatric disorders share a common and specific set of gene variants. more
These sponge-like gels can help grow new tissue, train immune cells, and deliver medication  PHYS.ORG · 2 days
In 2010, Sidi Bencherif was working in a lab at Harvard University, trying to use a surgically implantable structure to... more
Micro-RNAs keep stem cells from growing up too fast  PHYS.ORG · 2 days
There comes a point in every cell's life when it has to decide what it wants to be when it grows up. Young cells, so-called stem cells, take their clues... more
Ancient DNA confirms humans wiped out northern hemisphere's version of the penguin  PHYS.ORG · 2 days
The North Atlantic was once home to a bird that bore a remarkable similarity to penguins. The great auk, also known as "the original... more
Study: The human lifespan is written into our DNA  PHYS.ORG · 2 days
Humans have a "natural" lifespan of around 38 years, according to a new method we have developed for estimating the lifespans of different species by analyzing their DNA. more
Horizon Discovery adds predesigned synthetic single guide RNA to its product range  NEWS MEDICAL · 2 days
Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation technologies, today announced the addition of predesigned synthetic... more
Human genetics evidence predictive of drug development success, study shows  NEWS MEDICAL · 2 days
A new drug candidate is more likely to be approved for use if it targets a gene known to be linked to the disease; a finding that can... more
Deadly 'superbugs' destroyed by molecular drills  nanowerk · 2 days
Motorized molecules activated by light target and drill through highly antibiotic resistant bacteria and kill them within minutes. The molecules can open bacteria to attack by drugs they previously resisted. The strategy could be applied to... more
Rosalind meets Rosalind  ESA · 2 days
Image: The work of Dr Rosalind Franklin (1920-1958) is well known for being central to the discovery of the iconic double-helix structure of DNA, the fabric of life as we... more
Medical News Today: Could epigenome editing prevent developmental disorders?  MNT · 2 days
Using mice, scientists show how epigenome editing has promise as a way to fix disordered brain development that arises from a WAGR syndrome gene mutation. more
ACMG recommends evaluations of breast cancer patients before genetic testing  NEWS MEDICAL · 2 days
According to a statement on behalf of the American College of Medical Genetics and Genomics (ACMG) published Dec. 13 in the organization's official journal, Genetics in Medicine, there... more
Influenza research could pave way for new and improved drugs, vaccines  NEWS MEDICAL · 2 days
Researchers at the Centenary Institute and the University of Sydney have discovered a key reason as to why the influenza virus is so effective at establishing... more
Precision epigenome editing can repair genetic syndrome of intellectual disability  NEWS MEDICAL · 2 days
Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome,... more
New strategy could prevent side effects of targeted cancer treatment  NEWS MEDICAL · 2 days
Targeted, highly effective cancer treatments often produce debilitating side effects. This is the case with one commonly used therapy which works by blocking the epidermal growth factor receptor,... more
Scientists develop new method for targeted drug delivery to cancer cells  NEWS MEDICAL · 2 days
A team of scientists from Peter the Great St.Petersburg Polytechnic University together with their colleagues developed a method of targeted drug delivery to cancer cells. more
Research could pave way for regenerative TBI-IV therapy  NEWS MEDICAL · 2 days
A team of researchers from the University of Georgia's Regenerative Bioscience Center has found that neural exosomes- "cargo" molecules within the nervous system that carry messages to the brain- can minimize or... more
Could epigenome editing prevent developmental disorders?  MNT · 2 days
Using mice, scientists show how epigenome editing has promise as a way to fix disordered brain development that arises from a WAGR syndrome gene mutation. more
Research suggests contributory role of 'Asian glow' mutation and alcohol to Alzheimer’s  NEWS MEDICAL · 2 days
A new study from Stanford, published on December 12 in the journal Acta Neuropathologica Communications, suggests that an important enzyme that helps break down... more
Deadly 'superbugs' destroyed by molecular drills  PHYS.ORG · 2 days
Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again. more
Tiny quantum sensors watch materials transform under pressure  PHYS.ORG · 3 days
Since their invention more than 60 years ago, diamond anvil cells have made it possible for scientists to recreate extreme phenomena—such as the crushing pressures deep inside the Earth's mantle—or to enable... more
Tiny insects become 'visible' to bats when they swarm  PHYS.ORG · 3 days
Small insects that would normally be undetectable to bats using echolocation suddenly become detectable when they occur in large swarms. Arjan Boonman of Tel-Aviv University and colleagues present these findings... more
Achieving optimal collaboration when goals conflict  PHYS.ORG · 3 days
New research suggests that, when two people must work together on a physical task despite conflicting goals, the amount of information available about each other's actions influences how quickly and optimally they learn to collaborate. Vinil... more
Rice University study aims to clarify microscopic aspects of cancer initiation  NEWS MEDICAL · 3 days
When do cancer-prone cells turn into full-blown cancer? A Rice University scientist and his colleague believe there's a way to know. more
Scientists solve 3D structure of vaccinia virus RNA polymerase  NEWS MEDICAL · 3 days
For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host's nucleus can they find the machines, enzymes and building... more
Climate cycles and insect pests drive migration timing of reindeer's North American cousin  SCIENCE DAILY · 3 days
Biologists have discovered two unexpected drivers for migration timing that dispute long-held assumptions and provide insight into potential future effects of climate... more
Molecular drills target and destroy deadly superbugs  NEWS MEDICAL · 3 days
Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again. more
Study shows unexpected mechanism for lipid acquisition by breast cancer cells  NEWS MEDICAL · 3 days
High-fat diets and obesity have been shown to increase the risk of breast cancer and worsen outcomes and prognosis of breast cancer patients. A team of... more
Scientists discover specific neurons that promote reward-like behaviors, alcohol consumption  NEWS MEDICAL · 3 days
Scientists have known that a region of the brain called the central nucleus of the amygdala (CeA) plays a role in behaviors related to alcohol use and consumption... more
NIH-funded research finds differences in energy use by immune T cells in ME/CFS  NEWS MEDICAL · 3 days
New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome... more
Metabolic adaptation ensures survival of colon cancer cells  SCIENCE DAILY · 3 days
Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the... more
Insight into the neglected tropical disease sleeping sickness  SCIENCE DAILY · 3 days
Researchers have shed light on how the parasite which causes sleeping sickness multiples inside its host. Human African Trypanosomiasis or sleeping sickness, only occurs in Sub-Saharan Africa where an estimated 60 million... more
To the brain, straight from the vein: IV treatment for TBI  SCIENCE DAILY · 3 days
A team of researchers has found that neural exosomes -- 'cargo' molecules within the nervous system that carry messages to the brain -- can minimize or... more
New drug targets to treat Nipah virus  SCIENCE DAILY · 3 days
Nipah virus, which is transmitted to humans from bats and pigs, has a high mortality rate and there are no licensed drugs against it. Now, researchers have used information on the structure of the... more
Researchers examine p53-deficient colon cancer cells to identify how p53 impacts metabolic adaptation  NEWS MEDICAL · 3 days
Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to... more
Your genes aren't the only factor dictating Alzheimer's risk  SCIENCE DAILY · 3 days
In the first study published about Alzheimer's disease among identical triplets, researchers found that despite sharing the same DNA, two of the triplets developed Alzheimer's while one did not. more
Ocean microbes: Novel study underscores microbial individuality  SCIENCE DAILY · 3 days
A single drop of seawater can contain a wide representation of ocean microbes from around the world -- revealing novel insights into the ecology, evolution and biotechnology potential of the global microbiome. more
Deadly 'superbugs' destroyed by molecular drills  SCIENCE DAILY · 3 days
Motorized molecules activated by light target and drill through highly antibiotic resistant bacteria and kill them within minutes. The molecules can open bacteria to attack by drugs they previously resisted. The strategy could be applied to... more
Sensory coding mechanisms revealed by optical tagging of physiologically defined neuronal types  Science Magazine · 3 days
Neural circuit analysis relies on having molecular markers for specific cell types. However, for a cell type identified only by its circuit function, the... more
Imaging stress and magnetism at high pressures using a nanoscale quantum sensor  Science Magazine · 3 days
Pressure alters the physical, chemical, and electronic properties of matter. The diamond anvil cell enables tabletop experiments to investigate a diverse landscape of high-pressure... more
Magnetic measurements on micrometer-sized samples under high pressure using designed NV centers  Science Magazine · 3 days
Pressure can be used to tune the interplay among structural, electronic, and magnetic interactions in materials. High pressures are usually applied in the diamond... more
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition  Science Magazine · 3 days
The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some circumstances, p27 is associated with active CDK4,... more
Depletion of microbiome-derived molecules in the host using Clostridium genetics  Science Magazine · 3 days
The gut microbiota produce hundreds of molecules that are present at high concentrations in the host circulation. Unraveling the contribution of each molecule to host biology remains difficult.... more
A window into the hidden world of colons  SCIENCE DAILY · 3 days
Biomedical engineers have developed a system for real-time observations at the cellular level in the colon of a living mouse. It employs a magnetic system to stabilize the colon during imaging while... more
Dendritic cells could lead to better treatments for persistent infections, cancer  NEWS MEDICAL · 3 days
Autoimmune disorders such as rheumatoid arthritis, psoriasis, and Crohn's disease plague tens of millions of Americans and are the result of the body's immune system, whose... more
Blood transfusions: Fresh red blood cells no better than older ones  SCIENCE DAILY · 3 days
Findings from the ABC-PICU study on critically ill children may alter policies at hospitals where fresh red cells are preferentially used. more
Safer viruses for vaccine research and diagnosis  SCIENCE DAILY · 3 days
A new technology to produce safer 'hybrid' viruses at high volumes for use in vaccines and diagnostics for mosquito-borne diseases has been developed. more
Immune outposts inside kidney tumors predict post-surgery outcomes  SCIENCE DAILY · 3 days
Patients with well-supported immune cells in their tumors are more likely to control their cancers' growth for a longer time, an observation that could guide treatment decisions after surgery for kidney cancer.... more
Microglia monitor and protect neuronal function via specialized somatic purinergic junctions  Science Magazine · 3 days
Microglia are the main immune cells in the brain with roles in brain homeostasis and neurological diseases. Mechanisms underlying microglia-neuron communication remain elusive. Here, we identified... more
As epilepsy drugs fail nearly one-third of patients, scientists seek root causes of seizures  Science Magazine · 3 days
Leaps in gene sequencing and better animal models are changing how doctors understand, study, and sometimes treat epilepsy more
Medical News Today: Transport breakdown in brain cells may lead to Alzheimer's, Parkinson's  MNT · 3 days
New research in mice and flies suggests that failure to transport molecules that break down proteins in neurons may lead to neurodegenerative... more
Virus multiplication in 3D  SCIENCE DAILY · 3 days
Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level. more
Bovine kobuvirus in US  SCIENCE DAILY · 3 days
A virus that afflicts cattle that was first discovered in Japan in 2003 has made its way to the US, researchers report. more
Team finds bovine kobuvirus in US  PHYS.ORG · 3 days
A virus that afflicts cattle that was first discovered in Japan in 2003 has made its way to the U.S., researchers report in the journal Emerging Infectious Diseases. more
The mathematics of prey detection in spider orb-webs  PHYS.ORG · 3 days
Spider webs are one of nature's most fascinating manifestations. Many spiders extrude proteinaceous silk to weave sticky webs that ensnare unsuspecting prey who venture into their threads. Despite their elasticity, these webs... more
Virus multiplication in 3-D  PHYS.ORG · 3 days
For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host's nucleus can they find the machines, enzymes and building blocks with which they can multiply their genetic material before... more
Chemists' calculations may advance cancer prediction  PHYS.ORG · 3 days
When do cancer-prone cells turn into full-blown cancer? A Rice University scientist and his colleague believe there's a way to know. more
Chemists' calculations may advance cancer prediction  SCIENCE DAILY · 3 days
A computational study by chemists showed the dynamics of tumor formation don't necessarily correlate with clinical data on lifetime cancer risks. It suggests biomarkers may someday be able to help predict when mutations in cells will... more
Tracking lab-grown tissue with light  PHYS.ORG · 3 days
Someday, doctors would like to grow limbs and other body tissue for soldiers who have lost arms in battle, children who need a new heart or liver, and many other people with critical needs. Today, medical professionals can... more
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