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Food allergies: Mechanism underlying cross-reaction between cypress pollen and certain fruits revealed
NEWS MEDICAL Working in collaboration with teams from the Czech Republic and Japan, researchers from the Institut Pasteur, Assistance Publique - Hôpitaux de Paris (AP-HP), and... 2 days
Ocean channel in Bahamas marks genetic divide in Brazilian free-tailed bats
PHYS.ORG Brazilian free-tailed bats are expert flyers, capable of migrating hundreds of miles and regularly traveling more than 30 miles a night. But they pull up short... 3 days
Ocean channel in Bahamas marks genetic divide in Brazilian free-tailed bats
SCIENCE DAILY Brazilian free-tailed bats are expert flyers, capable of migrating hundreds of miles and regularly traveling more than 30 miles a night. But they pull up short... 3 days
Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors
Science Magazine Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could... 3 days
Research identifies new gene fusions and mutations linked to GIST tumors
NEWS MEDICAL Researchers at UC San Diego Moores Cancer Center, with colleagues from Memorial Sloan Kettering Cancer Center and Fox Chase Cancer Center, have determined that a specific... 3 days
Two-step process leads to cell immortalization and cancer
SCIENCE DAILY Immortalization of cells is a necessary step in the development of cancer, and scientists think that the main cause is turning on an enzyme -- telomerase -- that lengthens chromosomal telomeres and... 3 days
Gene variant activity is surprisingly variable between tissues
SCIENCE DAILY Every tissue has its own pattern of active alleles, a large-scale study has found. Researchers were able to show that the differential allele activity is regulated by tissue-specific, regulatory DNA elements known... 3 days
Histone 1, the guardian of genome stability
SCIENCE DAILY Genomic instability is the main risk factor for tumor development in humans. Therefore understanding its origin and and exploring therapeutic targets is paramount. Histone 1 silences a region of the genome that causes irreparable... 3 days
Mechanisms explaining positional diversity of the hindlimb in tetrapod evolution
SCIENCE DAILY Elucidating how body parts in their earliest recognizable form are assembled in tetrapods during development is essential for understanding the nature of morphological evolution. Researchers found in eight... 3 days
how we inherit masculine and feminine behaviours a new idea about environment and genes How we inherit masculine and feminine behaviours: a new idea about environment and genes
PHYS.ORG VIDEO The now infamous Google memo, written by engineer James Damore, has inflamed longstanding debates about the differences between women and... 3 days
Genome analysis with near-complete privacy possible, say researchers
SCIENCE DAILY It is now possible to scour complete human genomes for the presence of disease-associated genes without revealing any genetic information not directly associated with the inquiry, say researchers. 3 days
Exclusive: Inside The Lab Where Scientists Are Editing DNA In Human Embryos
NPR NPR gets exclusive access to a lab in Portland, Ore., where scientists have begun editing the DNA in human embryos to try to prevent... 3 days
A First Look: Inside The Lab Where Scientists Are Editing DNA In Human Embryos
NPR NPR gets exclusive access to a lab in Portland, Ore., where scientists have begun editing the DNA in human embryos... 3 days
Scientists reveal differences between human and murine microglia used in degenerative disease research
NEWS MEDICAL The results of a new research showed that many of the genes that are expressed by microglia are different between humans and... 3 days
Worm atlas profiles gene readouts in every cell type in the animal
SCIENCE DAILY A worm atlas has been built that profiles gene readouts for every kind of cell in the animal. This is the first time this... 3 days
New gene catalog of ocean microbiome reveals surprises
SCIENCE DAILY Oceanographers report completing the largest single-site microbiome gene catalog constructed to date. With this new information, the team discovered nutrient limitation is a central driver in the evolution of ocean microbe genomes. 3 days
New gene catalog of ocean microbiome reveals surprises
PHYS.ORG Microbes dominate the planet, especially the ocean, and help support the entire marine food web. In a recent report published in Nature Microbiology, University of Hawai'i at Mānoa (UHM) oceanography professor Ed... 4 days
New technique overcomes genetic cause of infertility
SCIENCE DAILY Scientists have created healthy offspring from genetically infertile male mice, offering a potential new approach to tackling a common genetic cause of human infertility. 4 days
Evolutionary history of imperiled salmon stocks
SCIENCE DAILY New technologies for analyzing DNA may transform how imperiled species are considered and managed for conservation protection, according to a study. These technologies can be applied to a wide range of species around the world --... 4 days
Gene that makes large, plump tomatoes identified
SCIENCE DAILY Farmers can grow big, juicy tomatoes thanks to a mutation in the cell size regulator gene that occurred during the tomato domestication process. 4 days
New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine
SCIENCE DAILY A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of... 4 days
Fertile offspring from sterile sex chromosome trisomic mice
Science Magazine Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy (SCT) affects 0.1% of the human population and is associated with infertility. We show that during... 4 days
Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism
Science Magazine TERT promoter mutations (TPMs) are the most common non-coding mutations in cancer. The timing and consequences... 4 days
Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis
Science Magazine Gene silencing by Polycomb complexes is central to eukaryotic development. Cold-induced epigenetic repression of FLOWERING LOCUS C (FLC) in the plant Arabidopsis... 4 days
DNA replication-coupled histone modification maintains Polycomb gene silencing in plants
Science Magazine Propagation of patterns of gene expression through the cell cycle requires prompt restoration of epigenetic marks after the twofold dilution caused by DNA replication. Here, we show that... 4 days
Comprehensive single-cell transcriptional profiling of a multicellular organism
Science Magazine To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial indexing RNA sequencing). We applied sci-RNA-seq to profile nearly... 4 days
Preventing mussel adhesion using lubricant-infused materials
Science Magazine Mussels are opportunistic macrofouling organisms that can attach to most immersed solid surfaces, leading to serious economic and ecological consequences for the maritime and aquaculture industries. We demonstrate that lubricant-infused coatings exhibit very low preferential mussel... 4 days
A pathology atlas of the human cancer transcriptome
Science Magazine Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level... 4 days
Deriving genomic diagnoses without revealing patient genomes
Science Magazine Patient genomes are interpretable only in the context of other genomes; however, genome sharing enables discrimination. Thousands of monogenic diseases have yielded definitive genomic diagnoses and potential gene therapy targets. Here we show how... 4 days
Researchers describe gene that makes large, plump tomatoes
PHYS.ORG Farmers can grow big, juicy tomatoes thanks to a mutation in the Cell Size Regulator gene that occurred during the tomato domestication process. Esther van der Knaap of the University of Georgia,... 4 days
Early Indian Ocean trade routes bring chicken, black rat to eastern Africa
PHYS.ORG The earliest introduction of domestic chickens and black rats from Asia to the east coast of Africa came via maritime routes between the 7th... 4 days
Worm atlas profiles gene readouts in every cell type in the animal
PHYS.ORG The roundworm stars in the first-ever compilation of gene readouts in every kind of cell in an animal. The readouts, which were taken at... 4 days
Male fruit flies can smell a good mate based on her metabolism
PHYS.ORG A female fruit fly must balance her energy usage between making eggs now and storing nutrients for later. This balance affects the pheromones that... 4 days
Scientists develop novel immunotherapy technology for prostate cancer
SCIENCE DAILY A novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer-specific protein has been described in a new article. 4 days
Medical News Today: Vitamin C may stop leukemia from progressing
MNT New research finds that high-dose vitamin C can genetically 'reprogram' leukemic cells to mature and die normally, instead of replicating to cause cancer. 4 days
Smithsonian manatee count informs policy recommendations
PHYS.ORG All three of the world's manatee species are threatened with extinction: the Amazonian Manatee, the African Manatee and the West Indian Manatee. The Antillean Manatee, an endangered subspecies, feeds and calves in rivers and coastal wetlands... 4 days
How the genome sets its functional micro-architecture
PHYS.ORG The genes that are involved in the development of the fetus are activated in different tissues and at different times. Their expression is carefully regulated by so-called "enhancer sequences", which are often located far... 4 days
Turkey bones may help trace fate of ancient cliff dwellers
PHYS.ORG Researchers say they have found a new clue into the mysterious exodus of ancient cliff-dwelling people from the Mesa Verde area of Colorado more than 700 years ago:... 4 days
How the genome sets its functional micro-architecture
SCIENCE DAILY Scientists now show how DNA is organized into specific regions, and that this depends on a combination of genomic distance and the presence of the CTCF protein. 4 days
Evolution of a killer—researchers study traces deadly fungus affecting bats
PHYS.ORG A new study from U of T Mississauga is shining a light on genetic changes happening in the darkest of places – bat caves. 4 days
Sharp X-ray pulses from the atomic nucleus
PHYS.ORG X-rays make the invisible visible: they permit the way materials are structured to be determined all the way down to the level of individual atoms. In the 1950s it was x-rays which revealed the... 4 days
Novel blood test identifies tumor-derived DNA in early-stage cancer patients
NEWS MEDICAL In a bid to detect cancers early and in a noninvasive way, scientists at the Johns Hopkins Kimmel Cancer Center report they have developed a test that spots... 4 days
White supremacists use a decision tree to affirm or discount the results of DNA tests
PHYS.ORG Now that science can determine a person's racial and ethnic origins from a cheek swab, those devoted to... 4 days
Medical News Today: Jumping genes made us human, but can they cause disease?
MNT Ancient bacteria and viruses left their traces all over our DNA. This may have given us an edge in our quest to... 4 days
Sanford Health launches solid tumor oncolytic virus clinical trial
NEWS MEDICAL Sanford Health is the first site in the United States to launch a clinical trial using a genetically-engineered virus that aims to destroy therapy-resistant tumors. 4 days
Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes
NEWS MEDICAL Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. 4 days
Research shows how glutamine plays role in regulating cellular differentiation programs
NEWS MEDICAL The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood... 4 days
Liquid biopsies show potential use for cancer screening
NEWS MEDICAL A new study has shown the potential of analyzing cell-free DNA (cfDNA) present in patients’ blood for cancer markers in early cancer detection. This technique was used in some instances for patients... 4 days
Fundamental pathology behind amyotrophic lateral sclerosis
SCIENCE DAILY Scientists have identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients. ALS is popularly known as Lou Gehrig’s... 4 days
Life at home affects kids at school, some more than others
SCIENCE DAILY Some children are more susceptible to changes than others. They carry the relationship with their parents to school with them. Genetics can help explain why. 4 days
Stress in the nest can have lifelong effect
SCIENCE DAILY Why do some sparrows hatch six chicks while others don’t hatch any? How does upbringing affect the remainder of their lives? Physiological stress in the nest can actually affect birds’ DNA and... 4 days
Problems with DNA replication can cause epigenetic changes that may be inherited for several generations
SCIENCE DAILY Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes... 5 days
Modern genetic sequencing tools give clearer picture of how corals are related
SCIENCE DAILY As corals face threats from ocean warming, a new study uses the latest genetic-sequencing tools to help unravel the relationships between three similar-looking corals. 5 days
The evolutionary basis of premature migration in Pacific salmon highlights the utility of genomics for informing conservation
Science Magazine The delineation of conservation units (CUs) is a challenging issue that has profound implications... 5 days
Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory
Science Magazine Impaired DNA replication is a hallmark of cancer and a cause of genomic instability. We report that, in addition to causing genetic change, impaired... 5 days
Adult-onset obesity is triggered by impaired mitochondrial gene expression
Science Magazine Mitochondrial gene expression is essential for energy production; however, an understanding of how it can influence physiology and metabolism is lacking. Several proteins from the pentatricopeptide repeat (PPR) family are... 5 days
[Research Articles] Direct detection of early-stage cancers using circulating tumor DNA
Science Magazine Early detection and intervention are likely to be the most effective means for reducing morbidity and mortality of human cancer. However, development of methods for noninvasive... 5 days
[Editors' Choice] Prostate cancer loses when androgen receptor cant stick the landing
Science Magazine A small-molecule inhibitor blocks the interaction of the androgen receptor with DNA to target drug-resistant prostate cancer. 5 days
[Research Articles] mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome
Science Magazine Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding... 5 days
Impaired DNA replication can cause epigenetic changes inherited for several generations
PHYS.ORG Cell division is key for renewing the cells in our tissues and organs. There are two particular processes in which cell division is crucial: embryonic development... 5 days
Study reveals the evolutionary history of imperiled salmon stocks
PHYS.ORG New technologies for analyzing DNA may transform how imperiled species are considered and managed for conservation protection, according to a study published today in the journal Science Advances and led... 5 days
Modern genetic sequencing tools give clearer picture of how corals are related
PHYS.ORG The documentary "Chasing Coral," released on Netflix in July, is a cinematic warning about how the bleaching of coral reefs may foreshadow how these... 5 days
Using barcodes to trace cell development
SCIENCE DAILY There are various concepts about how blood cells develop. However, they are based almost exclusively on experiments that solely reflect snapshots. Scientists now present a novel technique that captures the process in a dynamic way. Using... 5 days
Scientists identify basic biological mechanism that kills neurons in ALS
NEWS MEDICAL A team led by scientists at St. Jude Children's Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in... 5 days
Popular sungazer lizards under threat from poaching
SCIENCE DAILY The sungazer (Smaug giganteus), a dragon-like lizard species endemic to the Highveld regions of South Africa, is facing an assault on two fronts as farming and industrialization encroaches on its natural habitat -- which... 5 days
Study offers novel insights into how genetic variants play key role in human immune system
NEWS MEDICAL It is widely recognized that people respond differently to infections. This can partially be explained by genetics, shows... 5 days
Blood biopsy helps identify targetable genetic alterations in patients with cancer of unknown primary
NEWS MEDICAL Using fragments of circulating tumor DNA in blood, University of California San Diego School of Medicine researchers were able to... 5 days
Physicists measure complementary properties using quantum clones
PHYS.ORG (Phys.org)—In quantum mechanics, it's impossible to precisely and simultaneously measure the complementary properties (such as the position and momentum) of a quantum state. Now in a new study, physicists have cloned quantum states and... 5 days
popular sungazer lizards under threat from poaching Popular sungazer lizards under threat from poaching
PHYS.ORG VIDEO The Sungazer (Smaug giganteus), a dragon-like lizard species endemic to the Highveld regions of South Africa, is facing an assault on two fronts as farming and industrialisation encroaches on its natural habitat - which... 5 days
Genetic variants found to play key role in human immune system
SCIENCE DAILY It is widely recognized that people respond differently to infections. This can partially be explained by genetics, according to a new study. The findings offer novel... 5 days
Lab-grown miniature blood vessels mimic rare Hutchinson-Gilford Progeria Syndrome
NEWS MEDICAL Biomedical engineers have grown miniature human blood vessels that exhibit many of the symptoms and drug reactions associated with Hutchinson-Gilford Progeria Syndrome -- an extremely rare genetic disease that causes... 5 days
Change in protein production essential to muscle function
SCIENCE DAILY A group of genes involved in calcium handling undergoes a highly-regulated process called alternative splicing that changes the type of protein the genes produce as muscles transition from newborn to adult. 6 days
Using experimental and computational methods, researchers reveal workings of bacterial defense system
PHYS.ORG Central to understanding why bacteria become antibiotic resistant is knowing how bacteria respond to the drugs trying to kill them. In a new study,... 6 days
New genomic insights reveal a surprising two-way journey for apple on the Silk Road
SCIENCE DAILY New research reveals surprising insights into the genetic exchange along the Silk Road that brought us the modern apple. 6 days
'Acidic patch' regulates access to genetic information
SCIENCE DAILY Researchers have uncovered new details about the way in which DNA, which is tightly packed into the cell's nucleus, is unwound so that it can be read and transcribed into proteins. 6 days
How a nutrient, glutamine, can control gene programs in cells
SCIENCE DAILY Researchers show that an intracellular metabolite of glutamine, alpha-ketoglutarate, plays a role in regulating cellular differentiation programs by changing the DNA-binding patterns of the transcription factor CTCF and... 6 days
Viruses up their game in arms race with immune system
SCIENCE DAILY Myxoma virus -- introduced to control the rabbit population in Australia in 1950 -- has developed a deadly ability to suppress the immune response in host rabbits. This... 6 days
Genome sequencing method can detect clinically relevant mutations using 5 CTCs
SCIENCE DAILY Whole genome sequencing using long fragment read (LFR), a technology that can analyze the entire genomic content of small numbers of cells, detected potentially targetable mutations... 6 days
Artificial blood vessels mimic rare accelerated aging disease
SCIENCE DAILY Biomedical engineers have grown miniature human blood vessels using stem cells taken from patients with an extremely rare genetic disease called progeria that causes symptoms resembling accelerated aging in children. The blood... 6 days
How head-on collisions of DNA protein machines stop replication
SCIENCE DAILY Head-on collisions between the protein machines that crawl along chromosomes can disrupt DNA replication and boost gene mutation rates. This may be one of the ways bacteria control their evolution... 6 days
Skewing the aim of targeted cancer therapies
SCIENCE DAILY The aim of targeted gene-based cancer therapies could often be skewed from the start. A widespread concept about how cells produce proteins proved incorrect 62 percent of the time in a new study in... 6 days
Mercury is altering gene expression
SCIENCE DAILY Mercury causes severe neurological disorders in people who have consumed highly contaminated fish. Whereas we know about the element's extreme toxicity, what happens further down the food chain, all the way down to those microalgae that are the... 6 days
Five researchers share $500,000 prize for work on gene editing
PHYS.ORG Five researchers will share a $500,000 medical prize for their roles in developing a groundbreaking gene-editing tool that lets scientists alter the DNA of living cells. 6 days
How Gata4 helps mend a broken heart
SCIENCE DAILY Gata4 alone is able to reduce post-heart attack fibrosis and improve cardiac function in a rat model of heart attack. In rat fibroblasts in the lab, the molecular mechanism involves reduced expression of Snail,... 6 days
How head-on collisions of DNA protein machines stop replication
PHYS.ORG A new study describes how head-on collisions between protein machines on chromosomes can disrupt DNA replication and boost the rate of gene mutations that help bacteria survive hostile environments, resist... 6 days
Mercury is altering gene expression
PHYS.ORG The mercury found at very low concentrations in water is concentrated along the entire food chain, from algae via zooplankton to small fish and on to the largest fish—the ones we eat. Mercury causes severe and irreversible neurological... 6 days
New genomic insights reveal a surprising two-way journey for apple on the Silk Road
PHYS.ORG Centuries ago, the ancient networks of the Silk Road facilitated a political and economic openness between the nations of Eurasia.... 6 days
'Acidic patch' regulates access to genetic information
PHYS.ORG Chromatin remodelers—protein machines that pack and unpack chromatin, the tightly wound DNA-protein complex in cell nuclei—are essential and powerful regulators for critical cellular processes, such as replication, recombination and gene transcription and repression. In... 6 days
New study identifies gene critical to pancreatic cancer cell growth
NEWS MEDICAL Pancreatic cancer is a particularly deadly form of disease, and patients have few options for effective treatment. 6 days
Researchers develop and validate new assay that detects gene fusions in solid tumors
NEWS MEDICAL An assay that identifies a peculiar but important abnormality in cancer cells has been developed and validated by researchers at The Ohio... 6 days
Genetic mechanism prevents kidney injury after severe dehydration
SCIENCE DAILY In humans, even the most minor dehydration can compromise the kidneys causing lifelong, irreparable issues or even death. However, some animals living in desert environments are able to survive both acute and... 7 days
From thousands of suspects, researchers ferret out cancer-causing genes
SCIENCE DAILY A team of researchers has identified specific gene combinations that can cause deadly brain cancer glioblastoma, using new technology that can also pinpoint triggers of other types cancers. 7 days
Blood biopsy test reads platelets to detect human lung cancer
SCIENCE DAILY Researchers have designed a different approach to the liquid biopsy. Rather than looking for evidence of cancer DNA or other biomarkers in the blood, their test (called thromboSeq)... 7 days
From cancer evolution to personalized therapies
SCIENCE DAILY Being able to predict the resistance or sensitivity of a tumor cell to a drug is a key success-factor of cancer precision therapy. But such a prediction is made difficult by the fact that genetic alterations... 7 days
Medical News Today: Genetic drivers of deadly brain cancer uncovered
MNT Researchers have pinpointed a number of gene mutations that work together to cause glioblastoma, an aggressive and deadly brain cancer. 7 days
Genetic drivers of deadly brain cancer uncovered
MNT Researchers have pinpointed a number of gene mutations that work together to cause glioblastoma, an aggressive and deadly brain cancer. 7 days
Trophic coherence explains why networks have few feedback loops and high stability
PHYS.ORG (Phys.org)—Complexity – defined as having emergent properties or traits that are not a function of, and are therefore difficult or inherently impossible to predict... 7 days
Varroa mites -- bees' archenemies -- have genetic holes in their armor
SCIENCE DAILY Seemingly indestructible Varroa mites have decimated honeybee populations and are a primary cause of colony collapse disorder, or CCD. Scientists have found genetic holes... 7 days
Neonics put bumblebees at risk of extinction by hindering colony formation, study reveals
SCIENCE DAILY Bumblebees are less able to start colonies when exposed to a common neonicotinoid pesticide, according to a new study. The research has... 7 days
Varroa mites—bees' archenemies—have genetic holes in their armor
PHYS.ORG Seemingly indestructible Varroa mites have decimated honeybee populations and are a primary cause of colony collapse disorder, or CCD. 7 days
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How we inherit masculine and feminine behaviours: a new idea about environment and genes
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Popular sungazer lizards under threat from poaching
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