Genetics
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper like transcription regulator 1 (LZTR1) gene led...
The general transcription factor IID (TFIID) is a critical component of the eukaryotic transcription preinitiation complex (PIC) and is responsible for recognizing the core...
The LZTR1 protein, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, is implicated in human disease, yet its mechanism of action remains unknown. We found that Lztr1...
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG...
ChemistryGeneticsMicrobiologyBiology more... Science Magazine 7 minutes
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic...
One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry,...
Genetically engineered microbes such as bacteria and yeasts have long been used as living factories to produce drugs and fine chemicals. More recently, researchers have started to combine bacteria with semiconductor technology that, similar to solar...
The already-rare Stone's sheep of the Yukon is 20 per cent less common than previously thought, according to new research by biologists. The study examined 123 different DNA...
GeneticsMicrobiologyBiology more... SCIENCE DAILY 2 hours
Male salmon are maturing earlier and becoming smaller, and it shows in their genes. This was the discovery of a study that examined scale samples from salmon over a 40-year...
A team of researchers at Dalhousie University has found evidence that suggests hemimastigotes represent a major new branch of evolutionary life. In...
Coffee or tea is a bitter choice, a taste genetics study suggests.
GeneticsMicrobiologyBiology more... SCIENCE-NEWS 5 hours
A genetic analysis of samples taken from a large UK health database suggest that people who are more sensitive than their peers to the bitter taste of caffeine tend to drink more coffee —...
The majority of consumers, even those who prefer online shopping, think the extinction of brick-and-mortar stores would be bad for society, according to a...
Autism spectrum disorders are neurodevelopmental disorders characterized by communication disorders, altered social interactions and sensory and...
Cows that can withstand hotter temperatures. Cows born without pesky horns. Pigs that never reach puberty.
An international study published in the journal Blood by researchers led by Dr. Elie Haddad, a pediatric immunologist and researcher at CHU Sainte-Justine and professor at Université de Montréal, highlights the urgent need to develop better...
Call it instinct, but something compels some animals to behave in certain ways, perhaps programs in their genes. Researchers have directly connected activities of...
In the most comprehensive study of its kind, biologists have found that tropical and subtropical forests across South America's Andes Mountains are responding to warming temperatures...
EvolutionExtinction more... SCIENCE DAILY 23 hours
Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution...
RelativityGravityInfectionsUniverse more... Science Magazine 24 hours
An international study led by University of Miami tropical biologists reveals that tropical trees are migrating upslope to escape climate change, but not fast enough.
Modern medicine's ability to keep us alive makes it tempting to think human evolution may have stopped. Better healthcare disrupts a key driving force of evolution by keeping...
EvolutionThe Future more... PHYS.ORG 1 day
Shopping in your supermarket's produce section is like strolling through a museum of humanity's greatest inventions. Perfect ears of golden sweet corn;...
Male salmon are maturing earlier and becoming smaller, and it shows in their genes. This was the discovery of a study that examined scale samples from salmon in the River...
more... PHYS.ORG 1 day
For the first time astronomers have detected gravitational waves from a merged, hyper-massive neutron star. The scientists, Maurice van Putten of Sejong University in South Korea, and Massimo della Valle of the...
Call it instinct, but something compels some animals to behave in certain ways, perhaps programs in...
AnimalsConnectivity more... PHYS.ORG 1 day
The fin whale and mountain gorilla populations grew significantly due to efforts by conservationists to halt their descent towards extinction, the International Union for Conservation of Nature (IUCN) said Wednesday.
Biodiversity goes beyond species diversity. Another important aspect of biodiversity is genetic variation within species. A notable example is the immense variety of cultivars and landraces of crop plants and their wild...
more... PHYS.ORG 1 day
Researchers from Universidad Politécnica de Madrid have has achieved the functional recovery from a stroke after implanting silk fibroin hydrogels-encapsulated stem cells in stroke mice.
Inventions more... NEWS MEDICAL 1 day
A few hundred thousand years ago during Earth's most recent ice age, a beefy subspecies of spotted hyena that was...
Soil salinity is affecting large areas in the world and millions of farmers are faced with decreasing yields and many are even forced to migrate. Dutch scientists (Prof Dr. Gerrit van Straten (Wageningen University),...
more... PHYS.ORG 1 day
An analysis of dolphin genes has revealed information about their past migrations, showing just how crucial migrants might be for other populations.
more... PHYS.ORG 1 day
Paintings by Edward Hopper and Willem de Kooning sold for nearly $92 million and $69 million respectively in New York on Tuesday, setting new world record auction prices...
more... PHYS.ORG 1 day
The speed and error rate of DNA synthesis is influenced by the three-dimensional structure of the DNA. Using "third-generation" genome-wide DNA sequencing data, a team of...
Cancer more... NEWS MEDICAL 1 day
The next generation of biotech food is headed for the grocery aisles, and first up may be salad dressings or granola bars made with soybean oil genetically tweaked to be good for...
Gene Editing more... PHYS.ORG 1 day
Tiny microscopic worms, invisible to the naked eye, are helping scientists to better understand an extraordinarily complex biological pathway that...
AgingConnectivity more... NEWS MEDICAL 1 day
A new technology that relies on a moth-infecting virus and nanomagnets could be used to edit defective genes that give rise to diseases like...
Gene EditingInfections more... NEWS MEDICAL 2 days
Scientists have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results showed that DMAbs were expressed over a wide window of...
Clean EnergyInfections more... SCIENCE DAILY 2 days
While it has long been recognized that mutated gene NPM1 plays an important role in acute myeloid leukemia, no one has determined how the normal and the mutated...
Cancer more... NEWS MEDICAL 2 days
One important aspect of biodiversity is genetic variation within species. A notable example is the variety of cultivars of crop plants. Scientists have now characterized at the molecular level a world collection...
more... SCIENCE DAILY 2 days
The speed and error rate of DNA synthesis is influenced by the three-dimensional structure of the DNA. Using "third-generation" genome-wide DNA sequencing data, a team of researchers from Penn State...
Cancer more... PHYS.ORG 2 days
VIDEO Living cells depend absolutely on tubulin, a protein that forms hollow tube-like polymers, called microtubules, that form scaffolding for moving materials inside the cell. Tubulin-based microtubule scaffolding allows cells to move, keeps things in place or moves them around. When...
more... PHYS.ORG 2 days
Bioengineers have combined a virus that infects moths with magnetic nanoparticles to create a potential new therapy for inherited genetic diseases like muscular dystrophy, sickle cell, cystic fibrosis, spinal muscular atrophy and some forms of cancer.
InfectionsCancer more... SCIENCE DAILY 2 days
By temporarily silencing the expression of a critical gene, researchers fooled soybean plants into sensing they were under siege, encountering a wide range of stresses. Then,...
more... PHYS.ORG 2 days
Depression and obesity are known to be linked, but science has found the relationship between them hard to unpick. A new study uses genetic...
Obesity more... MNT 2 days
If you were to take a seed and zap it into the future to see how it will respond to climate change, how realistic might that prediction be? After all, seeds that actually grow in the...
Experimental therapy could repair mutations that cause genetic diseases.
more... nanowerk 2 days
Today's birds descend from a small number of bird species living before the dinosaur extinction. Some of the birds that went extinct, the enantiornithines, were actually more common than and out-competed modern...
AnimalsEvolutionExtinction more... SCIENCE DAILY 2 days
Researchers have used neural networks and supervised machine learning techniques to characterize cell types following single-cell RNA sequencing.
Networking more... NEWS MEDICAL 2 days
Plants have evolved ways to make ants defend them from attacks and spread their seeds, and this new study shows how it happened. In a new study breaking down the genetic history...
Evolution more... SCIENCE DAILY 2 days
Researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment of genetic conditions.
more... SCIENCE DAILY 2 days
Jairo Méndez Abreu and Adriana de Lorenzo-Cáceres, researchers at the Instituto de Astrofísica de Canarias (IAC), have discovered a peanut-shaped structure in the inner bar of a double-barred galaxy close to the Milky Way. Structures of this type, previously detected...
A new technology that relies on a moth-infecting virus and nanomagnets could be used to edit defective genes that give rise to diseases like sickle cell, muscular dystrophy and cystic...
A team of researchers from Universidad de Zaragoza, King's College London and the Institute of Astronomy in the U.K. has found that a "dark matter hurricane" passing through our solar system offers...
When a cell divides—a process known as mitosis—its chromosomes need to be separated and evenly distributed into the newly created daughter cells. Although this is known to be extremely complicated...
more... PHYS.ORG 2 days
A variety of animals have male-specific ornament traits and these ornaments are favored by female choice. Which male traits are preferred by females often varies among females. Genetic mechanisms that...
AnimalsEvolution more... PHYS.ORG 2 days
Computer scientists at Carnegie Mellon University say neural networks and supervised machine learning techniques can efficiently characterize cells that have been studied using single cell RNA-sequencing...
Networking more... PHYS.ORG 2 days
Cimone Stills, 15, has a medical condition that has caused her to have multiple seizures a day for most of her life. Specifically, she has treatment-resistant generalized epilepsy...
more... NEWS MEDICAL 2 days
Carnegie Mellon University researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform...
more... NEWS MEDICAL 3 days
When a cell divides—a process known as mitosis—its chromosomes need to be separated and evenly distributed into the newly created daughter cells. Although this is known to be...
more... NEWS MEDICAL 3 days
Analysis of ancient DNA of a mysterious extinct monkey named Xenothrix -- which displays bizarre body characteristics very different to any living monkey -- has revealed...
AnimalsEvolutionExtinction more... SCIENCE DAILY 3 days
By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that...
Animals more... NEWS MEDICAL 3 days
Analysis of ancient DNA of a mysterious extinct monkey named Xenothrix—which displays bizarre body characteristics very different to any living monkey—has revealed that it was in...
EvolutionExtinction more... PHYS.ORG 3 days
Plants are boring. They just sit there photosynthesizing while animals have all the fun. Right? Not so much. Take a look at the interactions between ants and plants—plants have evolved features specifically...
AnimalsEvolution more... PHYS.ORG 3 days
Researchers shed light on the protein complexes and processes that enable microtubules to bind to the centromeres of chromosomes and redistribute them to the daughter cells during mitosis. Via experiments...
more... SCIENCE DAILY 3 days
Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is...
more... NEWS MEDICAL 3 days
Researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment of genetic conditions.
more... nanowerk 3 days
Scientists have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If...
more... SCIENCE DAILY 3 days
Carnegie Mellon University researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment...
more... PHYS.ORG 3 days
Experimenting with lab-grown brain cancer cells, researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the...
more... SCIENCE DAILY 3 days
This experiment had a good chance of crashing. Instead, it delivered whopping evidence to coroborrate the earliest evolution of the translational system, the mechanisms which make...
Evolution more... SCIENCE DAILY 3 days
Metabarcoding, a technique of mass DNA sequencing, allows for tracing migratory routes of insects, an understudied subject due to technical limitations. A small DNA fragment of the pollen that insects transport is...
AnimalsBees more... PHYS.ORG 3 days
Researchers have established the trigger for catastrophic events that occur within the chromosomes of cancer cells and lead to cancer cell death.
more... NEWS MEDICAL 3 days
Citizens prefer to enjoy natural landscapes that combine nature with built infrastructure, and that are close and accessible. This is apparent from the results of a pioneering study developed by...
Social Media more... PHYS.ORG 3 days
VIDEO The way DNA folds largely determines which genes are read out. John van Noort and his group have quantified how easily rolled-up DNA parts stack. This costs less energy than previously assumed. Publication in...
more... PHYS.ORG 3 days
From elongated oblongs to near-perfect spheres, vegetables come in almost every size and shape. But what differentiates a fingerling potato from a russet or a Roma tomato from a beefsteak? Researchers at...
more... PHYS.ORG 3 days
Scientists at the German Cancer Research Center have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for...
more... NEWS MEDICAL 3 days
Last week The Howard de Walden Estate gathered medical experts from across the industry for a one day conference to discuss the future challenges of healthcare...
The Future more... NEWS MEDICAL 3 days
Common bacteria that cause foodborne diseases are resistant to antibiotics used to treat infections, according to research that identified 39 genes responsible for this resistance.
Infections more... SCIENCE DAILY 5 days
New research has identified a key factor in the case of a progressive form of hair loss that starts in early childhood. The main...
more... MNT 5 days
Genetics may predispose some people to both Alzheimer's disease and high levels of blood lipids such as cholesterol, a common feature of cardiovascular disease, according to a new...
Alzheimers more... SCIENCE DAILY 6 days
Newly published research shows that a saliva-based biomarker panel and associated algorithm could improve the ability to accurately identify children with autism spectrum disorder...
Autism more... NEWS MEDICAL 6 days
Genetics may predispose some people to both Alzheimer's disease and high levels of blood lipids such as cholesterol, a common feature of cardiovascular disease,...
Alzheimers more... NEWS MEDICAL 6 days
Researchers have made important insights into the link between genetic diversity and the intricate changes in peptides bound to human leukocyte antigen molecules -- which help the immune...
Infections more... SCIENCE DAILY 6 days
Epigenetic changes can bring about new traits without altering the sequence of genes. This may allow plants to respond quicker to changes in their environment. Plant biologists have now demonstrated that epigenetic variation is also subject...
more... SCIENCE DAILY 6 days
By about 7,000 years ago, ancient people who lived high in the Andes Mountains had developed bigger hearts and slightly higher blood pressure, among other adaptations, to better...
more... LIVE SCIENCE 6 days
Scientists have discovered a gene signature biomarker that may predict which patients will respond -- or not -- to immune therapy.
more... SCIENCE DAILY 6 days
Human SH2D1A mutations resulting in X-linked lymphoproliferative syndrome type 1 are associated with a unique susceptibility to the Epstein-Barr virus,...
Infections more... NEWS MEDICAL 6 days
EU research has investigated protein profiles for individual pigs so the producer will be able to determine the...
more... PHYS.ORG 6 days
A pair of researchers has found evidence at the Tulán-52 excavation in Chile that suggests the need for a reinterpretation of how the stone complex was used. In...
more... PHYS.ORG 6 days
Genetic studies of ancient remains are filling in the picture of who the earliest Americans were and how they spread through the Americas long...
more... SCIENCE-NEWS 6 days
Human impacts are the biggest risk factor in the possible extinction of a quarter of all land-based mammals, according to a University of Queensland study.
Virginia Tech Carilion Research Institute scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis-- also...
more... NEWS MEDICAL 7 days
How does the three-dimensional architecture of our genes affect the differentiation of cells and development of diseases? This is the question behind the European Innovation Training Network "ChromDesign-...
NetworkingInventions more... NEWS MEDICAL 7 days
Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, researchers have solved the long-standing mystery around why AMPK can both hinder and...
more... SCIENCE DAILY 7 days
Like humans, fruit flies are active during the day, sleep at night and have similar sleep characteristics. A study has discovered a new gene and uncovered a mechanism...
more... SCIENCE DAILY 7 days
Research on a newly rediscovered 9,000-year-old child's tooth has reshaped our understanding of Alaska's ancient people, their genetic background and their diets. The tooth is only the second known remnant...
Connectivity more... SCIENCE DAILY 7 days
People genetically linked to the Clovis culture, one of the earliest continentwide cultures in North America, made it down to South America as far back as 11,000 years ago. Then...
more... LIVE SCIENCE 7 days
Visualizing 'unfurling' microtubule growth
PHYS.ORG
Bending DNA costs less energy than assumed
PHYS.ORG
CRISPR opens door to new type of medicine—'genome surgery'
PHYS.ORG
Experimental work reproduces the knapping process at Olduvai
PHYS.ORG
New data tool can help scientists use limited funds to protect the greatest number of endangered species
PHYS.ORG