Genetics
Study: 15,000 cases of hypophosphatasia potentially undetected in Spanish population  NEWS MEDICAL · 8 hours
Hypophosphatasia (HPP) is a rare and serious hereditary disease that is potentially life-threatening and is caused by one or more mutations in the gene coding for alkaline phosphatase... more
Mining 'darkest' parts of the genome in cancer cells yields gold  NEWS MEDICAL · 9 hours
Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for... more
Genetics may determine who benefits from broccoli's effects on kidney health  SCIENCE DAILY · 9 hours
Deletion of the gene that codes for an enzyme called GSTM1 increased kidney injury in mice with hypertension and kidney disease, but supplementing the diet with... more
Early DNA lineages shed light on the diverse origins of the contemporary population  SCIENCE DAILY · 9 hours
A new genetic study demonstrates that, at the end of the Iron Age, Finland was inhabited by separate and differing populations, all... more
eDNA reveals where endangered birds of a feather flock together  PHYS.ORG · 10 hours
For the first time, Australian scientists have shown that environmental DNA (eDNA) can be used to detect the presence of an endangered bird species simply by collecting a... more
Researchers link sisters' paralysis to an 'extremely rare' genetic variant  SCIENCE DAILY · 10 hours
Following a nearly 25-year search across three continents, parents of a pair of sisters -- who as children slowly became paralyzed from the waist down -- finally have... more
Broccoli's effects on kidney health may depend on individual's genetics  NEWS MEDICAL · 10 hours
New research indicates that the benefits of a dietary compound on kidney health may depend on an individual's genetics. The findings, which appear in an upcoming issue of... more
Lichens are way younger than scientists thought  SCIENCE DAILY · 10 hours
Lichens -- a combo of fungus and algae -- can grow on bare rocks, so scientists thought that lichens were some of the first organisms to make their way onto land from the water,... more
Key Alzheimer's gene variants act differently among Caribbean Hispanics based on ancestry  NEWS MEDICAL · 11 hours
Researchers looking to uncover the mysteries of Alzheimer's disease have revealed new insights from old variants. more
A new kind of glue to bond polyethylene  PHYS.ORG · 11 hours
A team of researchers from the University of Victoria and the University of British Columbia, both in Canada, has developed a new kind of glue that is able to bond polyethylene materials... more
DNA may hold the clue to protecting endangered species  PHYS.ORG · 12 hours
A new method for analyzing DNA collected from waterways which can help identify endangered bird species has been developed with the help of researchers from The University of Western Australia. more
New role for dopamine in gene transcription and cell proliferation  SCIENCE DAILY · 12 hours
The dopamine D2 receptor has a previously unobserved role in modulating Wnt expression and control of cell proliferation, according to a new study. The research could have implications... more
A step closer to cancer precision medicine  SCIENCE DAILY · 12 hours
Researchers have developed a computational model, Combined Essentiality Scoring (CES), that enables accurate identification of essential genes in cancer cells for development of anti-cancer drugs. more
Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome  NEWS MEDICAL · 12 hours
In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning... more
A potential new way to diagnose male infertility and pharmaceutical treatment options  SCIENCE DAILY · 13 hours
New research has discovered infertile men have identifiable patterns of epigenetic molecules or biomarkers attached to their sperm DNA that aren't present in fertile... more
Bigger doesn't mean better for hatchery-released salmon  PHYS.ORG · 17 hours
Fish permeate the culture of the Pacific Northwest (PNW). In particular, the iconic salmon has been an important part of the region for thousands of years, from ancient Native American trade routes and legends... more
Research shows how bacteria associated with Crohn's disease tolerate antibiotics  NEWS MEDICAL · 22 hours
Bacteria associated with Crohn's disease rely on multiple stress responses to survive, multiply, and tolerate antibiotics within white blood cells called macrophages, according to a study published November... more
Non-coding enhancer DNA may be key for identifying genetic risk in neurological conditions  NEWS MEDICAL · 23 hours
One might think that the primary cause of most genetically linked diseases comes from mutations in coding DNA -- alterations in coding... more
Genes borrowed from bacteria allowed plants to move to land  SCIENCE DAILY · 1 day
Natural genetic engineering allowed plants to move from water to land, according to a new study. more
Altering malarial parasite genes to prevent malaria  NEWS MEDICAL · 1 day
Malaria is a mosquito-borne disease caused by the parasitic organism called Plasmodium, of which there are several types that cause the different kinds of malarial fever. This age-old infection still kills over 400,000 people... more
Brain cell type-specific enhancer-promoter interactome maps and disease risk association  Science Magazine · 1 day
Non-coding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic variation associated with brain diseases, we defined non-coding... more
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome  Science Magazine · 1 day
Down syndrome (DS) is the most common genetic cause of intellectual disability. Protein homeostasis is essential for normal brain function, but little... more
Cellular RNA surveillance in health and disease  Science Magazine · 1 day
The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding... more
DNA data offers scientific look at 500 years of extramarital sex in Western Europe  SCIENCE DAILY · 1 day
Researchers have put DNA evidence together with long-term genealogical data to explore questions of biological fatherhood on a broad scale... more
New computational model could help in the development of anti-cancer drugs  NEWS MEDICAL · 1 day
Researchers from the Faculty of Medicine and the Institute for Molecular Medicine at the University of Helsinki have developed a computational model, Combined Essentiality Scoring (CES)... more
Evolution can reconfigure gene networks to deal with environmental change  SCIENCE DAILY · 1 day
Scientists have unraveled the genetic mechanisms behind tiny waterfleas' ability to adapt to increased levels of phosphorus pollution in lakes. more
Observing changes in the chirality of molecules in real time  PHYS.ORG · 1 day
Some molecules can exist in two mirror-image forms, similar to our hands. Although such so-called enantiomers have almost identical physical properties, they are not the same. The fact... more
DNA data offers scientific look at 500 years of extramarital sex in Western Europe  PHYS.ORG · 1 day
These days it's easy to resolve questions about paternity with over-the-counter test kits. Now, researchers have put DNA evidence together... more
Genes borrowed from bacteria allowed plants to move to land  PHYS.ORG · 1 day
Natural genetic engineering allowed plants to move from water to land, according to a new study by an international group of scientists from Canada, China, France, Germany, and... more
Gene deletion study identifies many new targets in malaria pathogen  PHYS.ORG · 1 day
Despite great efforts in medicine and science, more than 400,000 people worldwide are still dying of malaria. The infectious disease is transmitted by the bite of mosquitoes infected... more
MicroRNA comprehensively analyzed  PHYS.ORG · 1 day
Messenger RNA transmits genetic information to the proteins, and microRNA plays a key role in the regulation of gene expression. Scientists from the Moscow Institute of Physics and Technology and the Research Centre for Medical Genetics have described the complex... more
New RNA molecules may play a role in aging  SCIENCE DAILY · 2 days
Using a new sequencing method, this class of previously invisible RNA molecules were found to be abundantly expressed. more
How to make better biofuels? Convince yeast it's not starving  PHYS.ORG · 2 days
Yeast already helps make bread and beer and cranks out the biofuel ethanol, but scientists believe it can be used to create an even more efficient fuel called... more
New RNA molecules may play a role in aging  PHYS.ORG · 2 days
The genome is the master plan for all body parts, from toe nails to eyebrows. But it's not just the blueprint that determines what's built. All of the cellular players... more
Researchers unravel protective properties of telomere t-loops  SCIENCE DAILY · 2 days
Loops at the ends of telomeres play a vital protective role preventing damage to chromosomes, according to new research. The study showed how the winding and unwinding of 't-loops' at the end of telomeres... more
Extinct giant ape directly linked to the living orangutan  SCIENCE DAILY · 2 days
Researchers have succeeded in reconstructing the evolutionary relationship between a two million year old giant primate and the living orangutan. It is the first time genetic material this old has... more
Precisely poking cells en masse to cure cancer  SCIENCE DAILY · 2 days
A novel microfluidic device addresses one of the most costly steps in the engineered cell therapy manufacturing process, namely gene delivery. Deterministic mechanoporation, or DMP, uses fluid flow to pull each cell... more
Evolution can reconfigure gene networks to deal with environmental change  PHYS.ORG · 2 days
Scientists at the University of Birmingham have unravelled the genetic mechanisms behind tiny waterfleas' ability to adapt to increased levels of phosphorus pollution in lakes. more
Something old, something new in the ocean's blue  SCIENCE DAILY · 2 days
Microbiologists have discovered a new metabolic process in the ocean. Ranging from molecular structures of individual genes and detection of their global distribution, their results give insight into the pathway process and... more
Predicting evolution: Not just 'survival of the fittest'  SCIENCE DAILY · 2 days
A new method of 're-barcoding' DNA allows scientists to track rapid evolution in yeast. The approach has implications for the prediction of dominant viral strains. more
New artificial intelligence system automatically evolves to evade internet censorship  SCIENCE DAILY · 2 days
Researchers developed a tool called Geneva (short for Genetic Evasion), which automatically learns to circumvent censorship. Tested in China, India and Kazakhstan, Geneva found dozens of ways to... more
New method could optimize facial analysis to detect genetic syndromes  NEWS MEDICAL · 2 days
Each year, over a million children are born with a genetic disease. Although about half of genetic syndromes present facial dysmorphology, abnormal facial features are often subtle at... more
The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation  Science Magazine · 2 days
Cas9 is an RNA-guided endonuclease that targets complementary DNA for cleavage and has been repurposed for many biological usages. Cas9... more
Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling  Science Magazine · 2 days
The genetic bases for most human sleep disorders and for variation in human sleep quantity and quality are largely unknown. Using the zebrafish, a diurnal vertebrate,... more
China's huge mysterious extinct ape 'Giganto' was an orangutan cousin  REUTERS · 2 days
Genetic material extracted from a 1.9 million-year-old fossil tooth from southern China shows that the world's... more
Scientists explore expansion of cytotoxic CD4 T-cells in supercentenarians  NEWS MEDICAL · 2 days
Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians--meaning people over the... more
Extinct giant ape directly linked to the living orangutan  PHYS.ORG · 2 days
By using ancient protein sequencing, researchers have retrieved genetic information from a 1.9 million year old extinct, giant primate that used to live in a subtropical area in southern China.... more
Leukemia type B cell can transform into a macrophage through epigenetic changes  NEWS MEDICAL · 2 days
All the tissues of our body have the same DNA, but they perform very different functions and have very different aspects. more
Spot the difference: Two identical-looking bird species with very different genes  SCIENCE DAILY · 2 days
While reports of species going extinct are sadly becoming common, an international team of scientists has identified a new species of bird living on the Southern... more
Molecular Scissors Could Help Keep Some Viral Illnesses At Bay  NPR · 2 days
A new technique uses the CRISPR molecule to snip away at the part of RNA viruses that allows them to spread infection by making copies of themselves. more
Could cytotoxic T-cells be a key to longevity?  SCIENCE DAILY · 2 days
Scientists have used single-cell RNA analysis to find that supercentenarians -- meaning people over the age of 110 -- have an excess of a type of immune cell called cytotoxic CD4 T-cells. more
Oldest carnivorous dinosaur fossil unearthed in Brazil  PHYS.ORG · 2 days
A team of researchers from Universidade Federal de Santa Maria and Universidade de São Paulo, both in Brazil, has found and identified the oldest carnivorous dinosaur fossil to date. In their paper published in... more
What is a 'mass extinction' and are we in one now?  PHYS.ORG · 2 days
For more than 3.5 billion years, living organisms have thrived, multiplied and diversified to occupy every ecosystem on Earth. The flip side to this explosion of... more
Scientists find two identical-looking bird species have very different genes  PHYS.ORG · 3 days
While reports of species going extinct are sadly becoming common, an international team of scientists has identified a new species of bird living on the Southern coast of... more
Genetic engineering tools produce better-modified plants faster, easier  PHYS.ORG · 3 days
Plants have big genomes; a rare flower from Japan has a genome that is 50 times the size of a human's. These huge genomes, and associated large genes, can make it challenging... more
Gold mining critically impairs water quality in rivers across Peruvian biodiversity hotspot  SCIENCE DAILY · 3 days
A new study finds that artisanal-scale gold mining is altering water clarity and dynamics in the Madre de Dios River watershed in Peru, a... more
Songbirds sing species-specific songs  SCIENCE DAILY · 3 days
The generation of species-specific singing in songbirds is associated with species-specific patterns of gene activity in brain regions called song nuclei, according to a new study. According to the authors, the findings could be a promising step toward a better... more
Widespread misinterpretation of gene expression data  PHYS.ORG · 3 days
Reproducibility is a major challenge in experimental biology, and with the increasing complexity of data generated by genomic-scale techniques this concern is immensely amplified. RNA-seq, one of the most widely used methods in modern molecular biology,... more
Songbirds sing species-specific songs  PHYS.ORG · 3 days
The generation of species-specific singing in songbirds is associated with species-specific patterns of gene activity in brain regions called song nuclei, according to a study published November 12 in the open-access journal PLOS Biology by Kazuhiro Wada of Hokkaido University... more
New collection showcases cutting-edge techniques in insect morphology and systematics  PHYS.ORG · 3 days
While the field of morphology—the study of the form and function of organisms—is centuries old, the last two decades have brought incredible leaps forward through the emergence of... more
New research explains how HIV avoids getting ZAPped  SCIENCE DAILY · 3 days
Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies -- proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak... more
Widespread misinterpretation of gene expression data  SCIENCE DAILY · 3 days
Reproducibility is a major challenge in experimental biology. New research identifies a frequent technical bias in data generated by RNA-seq technology, which allows in a single test the simultaneous measurement of the expression level of all... more
Collaborative study shows sex-specific processes in schizophrenia and bipolar disorder  NEWS MEDICAL · 3 days
Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than... more
Small RNAs link immune system and brain cells  SCIENCE DAILY · 3 days
A collaborative study shows sex-specific biases in disease-specific changes in brain cells, as well as in cellular control mechanisms based on endogenous short ribonucleic acid (RNA) chains. more
Applying biodiversity conservation research in practice  SCIENCE DAILY · 3 days
One million species are threatened with extinction, many of them already in the coming decades. This unprecedented loss of biodiversity threatens valuable ecosystems and human well-being. But what is holding us back from putting conservation research... more
Boosting host immune defenses to treat tuberculosis  SCIENCE DAILY · 3 days
A study suggests a new approach that might help treat Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis: making people's cells better at killing Mtb by harnessing RNA sensors in our cells, which detect... more
Applying biodiversity conservation research in practice  PHYS.ORG · 3 days
One million species are threatened with extinction, many of them already in the coming decades. This unprecedented loss of biodiversity threatens valuable ecosystems and human well-being. But what is holding us back from putting conservation research... more
Using CRISPR for dose-dependent activation of gene expressions  PHYS.ORG · 3 days
A team of researchers affiliated with several institutions in the U.S. has developed a way to use the CRISPR gene editing technique for dose-dependent activation of gene expressions. In their paper published... more
Putting a conservation finger on the internet's pulse  PHYS.ORG · 3 days
Scientists from the University of Helsinki have figured out how to mine people's online reactions to endangered animals and plants so that they can reduce the chance of pushing species toward extinction. more
Evidence found of gene markers that may help people survive at high altitudes  PHYS.ORG · 3 days
A team of researchers with members from several institutions in the U.S., one from Peru and one from India, has found evidence... more
High resolution cryo-EM images from Africa pave the way to bespoke nitrilases for industry  PHYS.ORG · 4 days
A team from Cape Town have recently published the first high-resolution cryo-electron microscopy (EM) paper to originate from Africa. As... more
DNA Just One of More Than 1 Million Possible 'Genetic Molecules,' Scientists Find  LIVE SCIENCE · 4 days
Scientists used a computer program to uncover more than 1 million molecules that could potentially store genetic information, just like DNA. more
How two strains of one bacterium combine to cause flesh-eating infection  SCIENCE DAILY · 4 days
A new study used genetic analysis to reveal how two different strains of a single species of flesh-eating bacteria worked in concert to become more dangerous... more
New research explains how HIV avoids getting ZAPped  PHYS.ORG · 4 days
Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies—proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak into our... more
Gold mining critically impairs water quality in rivers across Peruvian biodiversity hotspot  PHYS.ORG · 4 days
A Dartmouth study finds that artisanal-scale gold mining is altering water clarity and dynamics in the Madre de Dios River watershed in Peru, a... more
Vietnam deer rediscovered after nearly 30 years  PHYS.ORG · 4 days
A very rare species of small, deer-like animal thought to be on the verge of extinction has been spotted in the northwestern jungle of Vietnam for the first time in nearly 30 years. more
For the first time: A method for measuring animal personality  SCIENCE DAILY · 4 days
A study on mice shows animal research may need to take into account the connection between genes, behavior and personality. more
CRISPR: More than just for gene editing?  SCIENCE DAILY · 4 days
Researchers have converted the CRISPR 'recognition induced enzymatic signal' to an electrical signal, which was then used to detect the biomarkers for viruses such as HPV or parvo. They hope the end result could... more
DNA is only one among millions of possible genetic molecules  SCIENCE DAILY · 4 days
Biology encodes information in DNA and RNA, complex molecules finely tuned to their functions. Although, other nucleic acid-like polymers are known, yet much remains unknown regarding possible alternatives... more
Sensitivity to bitter tastes may be why some people eat fewer vegetables  SCIENCE DAILY · 4 days
A gene that makes some compounds taste bitter may make it harder for some people to add heart-healthy vegetables to their diet. Researchers hope... more
Better biosensor technology created for stem cells  SCIENCE DAILY · 4 days
A team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders. The technology, which features a unique graphene and... more
DNA SOS: Understanding DNA signaling pathways  PHYS.ORG · 5 days
When cells suffer DNA damage, they send out an SOS signal. When the repair crew arrives, the emergency signal is cancelled as it is no longer needed. This two-stage process is an important one in many... more
DNA is only one among millions of possible genetic molecules  PHYS.ORG · 5 days
Biology encodes information in DNA and RNA, which are complex molecules finely tuned to their functions. But are they the only way to store hereditary molecular information? Some... more
Horizon Discovery announces divestment of animal models business to Envigo  NEWS MEDICAL · 5 days
Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation technologies, today announces an agreement to divest the Group’s animal research models... more
New point-of-care medical device rapidly and accurately detects viruses  NEWS MEDICAL · 5 days
The gene-editing tool CRISPR has been heralded as a scientific miracle destined to eradicate diseases from sickle-cell anemia to cancer, or decried as "the genetic scissors that tailor the human... more
DNA is only one among millions of possible genetic molecules  nanowerk · 5 days
Scientists computed a zoo of millions of alternate genetic polymer molecular structures, giving context for why biology encodes information how it does, and providing potential leads for new... more
Better biosensor technology created for stem cells  nanowerk · 5 days
Researchers have created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders. The technology, which features a unique graphene and gold-based... more
CRISPR: More than just for gene editing?  PHYS.ORG · 5 days
The gene-editing tool CRISPR has been heralded as a scientific miracle destined to eradicate diseases from sickle-cell anemia to cancer, or decried as "the genetic scissors that tailor the human gene pool," an ethically... more
Synthetic DNA technology applied as a novel strategy for delivery of anti-HIV antibodies  nanowerk · 6 days
Synthetic DNA-encoded monoclonal antibodies (DMAbs) allow for in vivo production of broadly neutralizing antibodies in preclinical studies. more
Genetic diversity impacts efficacy of cancer immunotherapy  NEWS MEDICAL · 7 days
The constant battle against infectious pathogens has had a decisive influence on the human immune system over the course of our evolution. more
DNA technology as a novel strategy for delivery of anti-HIV antibodies  SCIENCE DAILY · 1 week
Scientists applied synthetic DNA-based technology to drive in vivo production of broadly neutralizing anti-HIV antibodies in small and large-animal models, providing proof of concept for a... more
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