Genetics
'Jumping genes' help stabilize DNA folding patterns  SCIENCE DAILY · 5 hours
The DNA molecule inside the nucleus of any human cell is more than six feet long. To fit into such a small space, it must fold into precise loops that also govern how genes... more
First glioblastoma patient treated with genetically modified poliovirus at UH  NEWS MEDICAL · 6 hours
University Hospitals Seidman Cancer Center treated its first patient in a new clinical trial to validate the groundbreaking effects of the poliovirus on glioblastoma, a deadly Grade IV... more
'Jumping genes' help stabilize DNA folding patterns  PHYS.ORG · 6 hours
"Jumping genes"—bits of DNA that can move from one spot in the genome to another—are well-known for increasing genetic diversity over the long course of evolution. Now, new research at Washington University School of... more
Jumping genes play surprising role in stabilizing DNA folding patterns  NEWS MEDICAL · 7 hours
"Jumping genes" -- bits of DNA that can move from one spot in the genome to another -- are well-known for increasing genetic diversity over the long course... more
30-year study of MSUD highlights critical need for more effective disease-modifying therapies  NEWS MEDICAL · 7 hours
A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup... more
Human DNA-PK activates a STING-independent DNA sensing pathway  Science Magazine · 7 hours
Detection of intracellular DNA by the cGAS-STING pathway activates a type I interferon-mediated innate immune response that protects from virus infection. Whether there are additional DNA sensing pathways, and how such pathways... more
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation  Science Magazine · 7 hours
T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high-affinity, isotype-switched antibodies. In a... more
Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli  Science Magazine · 7 hours
Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance, virulence, and other traits among bacterial populations. The environmental and genetic forces that drive... more
A single number aids biomedical data scientists in finding deadly cancer cells  NEWS MEDICAL · 8 hours
Biomedical data scientists at the Stanford University School of Medicine have shown that the number of genes a cell uses to make RNA is... more
Mapping the cumulative health effects of environmental exposures  SCIENCE DAILY · 10 hours
The genomics revolution has provided powerful insights into genetic risk factors for human disease while also revealing the limits of genetic determinants, which account for only a fraction of total disease risk.... more
The regulators active during iron deficiency  PHYS.ORG · 11 hours
Iron deficiency is a critical situation for plants, which respond using specific genetic programmes. Biologists from Heinrich Heine University Düsseldorf (HHU) and Michigan State University (MSU) used artificial intelligence methods to examine how to predict regulatory... more
Iron overload, variant gene and malaria resistance linked in African study  NEWS MEDICAL · 12 hours
A new study shows that a rare genetic mutation giving rise to a variant of the TP53 gene called P47S causes several linked biological processes. more
UC Davis MIND Institute provides care for those born with fragile X syndrome disorder  NEWS MEDICAL · 19 hours
Fragile X syndrome is a debilitating genetic neurodevelopmental disorder that affects people worldwide, but many doctors don't know anything about... more
RB1 alterations in cancer cells may lead to treatment resistance  NEWS MEDICAL · 20 hours
The Cancer Genetics Group of the Josep Carreras Leukaemia Research Institute, led by Montse Sánchez-Céspedes, together with Luis Montuenga from CIMA, and Enriqueta Felip from Vall d'Hebron Hospital,... more
Halting metastasis by preventing cancer cells from using fat  NEWS MEDICAL · 1 day
Healthy cells normally undergo cell division, but when a genetic mutation causes uncontrolled cell growth, they form a tumor. Cancer is one of the leading causes of death worldwide, and... more
Scientists uncover genetic information of what keeps us healthy  NEWS MEDICAL · 1 day
Genetics plays a role in the overall health and well-being of humans. Genes provide instructions for making proteins, which help determine the structure and function of each cell in the... more
Astronomers detect large amounts of oxygen in ancient star's atmosphere  PHYS.ORG · 1 day
An international team of astronomers from the University of California San Diego, the Instituto de Astrofísica de Canarias (IAC), and the University of Cambridge have detected large amounts... more
Two-drug combo halts the growth of cancer cells  SCIENCE DAILY · 1 day
Researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations. more
Urine fertilizer: 'Aging' effectively protects against transfer of antibiotic resistance  SCIENCE DAILY · 1 day
Recycled and aged human urine can be used as a fertilizer with low risks of transferring antibiotic resistant DNA to the environment, according to new research. more
Landmark study identifies 102 genes associated with autism risk  NEWS MEDICAL · 1 day
In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with risk for autism. The study also shows significant progress towards... more
Researchers identify novel cellular entry factor for AAV vector types  NEWS MEDICAL · 1 day
Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors... more
Mechanism for how common gene therapy vectors enter cells  SCIENCE DAILY · 1 day
Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types -- the most commonly used viral vectors for in vivo gene therapy. The researchers identified that... more
New understanding of condensation could lead to better power plant condenser, de-icing materials  SCIENCE DAILY · 1 day
For decades, it's been understood that water repellency is needed for surfaces to shed condensation buildup - like the droplets of water... more
Lineage tracing on transcriptional landscapes links state to fate during differentiation  Science Magazine · 1 day
A challenge in biology is to associate molecular differences among progenitor cells with their capacity to generate mature cell types. Here, we use expressed DNA barcodes... more
A two-way molecular dialogue between embryo and endosperm is required for seed development  Science Magazine · 1 day
The plant embryonic cuticle is a hydrophobic barrier deposited de novo by the embryo during seed development. At germination, it protects the... more
Single-cell transcriptional diversity is a hallmark of developmental potential  Science Magazine · 1 day
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation is challenging. Here, we demonstrate a simple, yet... more
A two-drug combo that halts growth of cancer cells discovered  NEWS MEDICAL · 1 day
UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations. more
Transcriptional scanning in the sperm may regulate rate of human evolution  NEWS MEDICAL · 1 day
Maturing sperm cells turn on most of their genes, not to follow their genetic instructions like normal, but instead to repair DNA before passing it to... more
New understanding of condensation could lead to better power plant condenser, de-icing materials  PHYS.ORG · 1 day
For decades, it's been understood that water repellency is needed for surfaces to shed condensation buildup—like the droplets of water that form... more
Global warming could have a negative impact on biodiversity generation processes  PHYS.ORG · 1 day
In the current climate change scenario, an international team led by researchers from Pablo de Olavide University (UPO) and the Autonomous University of Madrid (UAM) has... more
Immune system cells facilitate the invasive capacity of glioblastoma  NEWS MEDICAL · 1 day
In a study published in Brain Communications, a new Open Access publication of the well-known journal Brain, the team led by Carlos Barcia, researcher at Institut de Neurociències of the... more
Scientists discover new drug target for prostate cancer in the non-coding genome  NEWS MEDICAL · 1 day
Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design. more
Scanning system in sperm may control rate of human evolution  PHYS.ORG · 1 day
Maturing sperm cells turn on most of their genes, not to follow their genetic instructions like normal, but instead to repair DNA before passing it to the next... more
A new way to count and identify microscopic particles in fluids  nanowerk · 1 day
A new method is proposed to automate the measurement of nano- to microscale particles suspended in fluid. The single particle extinction and scattering (SPES) method can... more
New cages to trap molecules push boundaries of protein design  PHYS.ORG · 1 day
Protein design is a popular and rapidly growing field, with scientists engineering novel protein cages—capsule-like nanostructures for purposes such as gene therapy and targeted drug delivery. Many of... more
Genome reference database can help predict disease-linked gene variants more accurately  NEWS MEDICAL · 1 day
Most diseases have a genetic component. To better understand disease, researchers led by the Garvan Institute of Medical Research are analysing genetic information to determine what... more
Scientists discover the mechanism of DNA high-order structure formation  PHYS.ORG · 2 days
The genetic material of our cells—DNA—exists in a high-order structure called chromatin. Chromatin consists of DNA wrapped around histone proteins and efficiently packs DNA into a small volume. Moreover, using... more
A new approach to reveal the multiple structures of RNA  PHYS.ORG · 2 days
Experimental data and computer simulations have yielded an innovative technique to characterize the configurations of an RNA molecule. The work, published in Nucleic Acids Research, opens new roads... more
Artificial cells react to environmental changes  PHYS.ORG · 2 days
Cells are the basic unit of life. They provide an environment for the fundamental molecules of life to interact, for reactions to take place and sustain life. However, the biological cell is very complicated, making it... more
Synthego adopts GMP standards for producing sgRNA  NEWS MEDICAL · 2 days
Synthego has adopted Good Manufacturing Practice standards for producing customized GMP-grade synthetic guide RNA at its facilities, an initiative the company said will benefit its academic and industry customers as they develop advanced cell... more
New discovery changes the understanding of gene expression  NEWS MEDICAL · 2 days
A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. more
Oldest African DNA on record shines light on the deep human past  NEWS MEDICAL · 2 days
A team of international researchers, which includes a Saint Louis University Madrid anthropologist, dug deep to find some of the oldest African DNA on... more
Possible Alzheimer's breakthrough suggested  SCIENCE DAILY · 2 days
Researchers say they have identified a previously unknown gene and associated protein (which they have named 'aggregatin') which could potentially be suppressed to slow the advance of Alzheimer's disease. more
Scientists identify gene that puts brakes on tissue growth  SCIENCE DAILY · 2 days
The planarian flatworm is a simple animal with a mighty ability: it can regenerate itself from nearly every imaginable injury, including decapitation. Scientists have studied these worms for decades to... more
Here, there and everywhere: Large and giant viruses abound globally  SCIENCE DAILY · 2 days
Scientists have uncovered a broad diversity of large and giant viruses that belong to the nucleocytoplasmic large DNA viruses (NCLDV) supergroup. As a result, virus diversity in this... more
'Ghost' population of humans discovered in ancient Africa  LIVE SCIENCE · 2 days
The ancient DNA from four children who lived thousands of years ago is rewriting what geneticists thought happened in sub-Saharan Africa. more
Surprise discovery shakes up our understanding of gene expression  SCIENCE DAILY · 2 days
A group of scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest... more
Surprise discovery shakes up our understanding of gene expression  PHYS.ORG · 2 days
A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. more
Molecular biologists identify gene that puts brakes on tissue growth  NEWS MEDICAL · 2 days
The planarian flatworm is a simple animal with a mighty and highly unusual ability: it can regenerate itself from nearly every imaginable injury, including decapitation. These tiny worms... more
Domesticated wheat has complex parentage  SCIENCE DAILY · 2 days
Certain types of domesticated wheat have complicated origins, with genetic contributions from wild and cultivated wheat populations on opposite sides of the Fertile Crescent. more
A heart-healthy protein from bran of cereal crop  SCIENCE DAILY · 2 days
Foxtail millet is an annual grass grown widely as a cereal crop in parts of India, China and Southeast Asia. Milling the grain removes the hard outer layer, or bran, from the... more
Single-cell morphology encodes metastatic potential  Science Magazine · 2 days
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and,... more
Isothermal digital detection of microRNAs using background-free molecular circuit  Science Magazine · 2 days
MicroRNAs, a class of transcripts involved in the regulation of gene expression, are emerging as promising disease-specific biomarkers accessible from tissues or bodily fluids. However, their accurate quantification from biological... more
[Research Articles] PI4KIII{beta} is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma  Science Magazine · 2 days
Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet, the molecular underpinnings and therapeutic implications of this feature remain unclear.... more
[Research Articles] Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site  Science Magazine · 2 days
Arthropod-borne viruses (arboviruses) are important human pathogens for which there are no specific antiviral medicines. The abundance of genetically distinct... more
[Research Articles] The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas  Science Magazine · 2 days
Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut)... more
Scientists identify gene that puts brakes on tissue growth  PHYS.ORG · 2 days
The planarian flatworm is a simple animal with a mighty and highly unusual ability: it can regenerate itself from nearly every imaginable injury, including decapitation. These tiny worms can regrow... more
First mushrooms appeared earlier than previously thought  PHYS.ORG · 2 days
According to a new study led by Steeve Bonneville from the Université libre de Bruxelles, the first mushrooms evolved on Earth between 715 and 810 million years ago, 300 million years earlier than the... more
Domesticated wheat has complex parentage  PHYS.ORG · 2 days
Certain types of domesticated wheat have complicated origins, with genetic contributions from wild and cultivated wheat populations on opposite sides of the Fertile Crescent. Terence Brown and colleagues at the University of Manchester report these findings in a... more
Genetic identification of human remains from the Spanish Civil War and the dictatorship  PHYS.ORG · 2 days
It is estimated that around 114,000 people disappeared throughout Spain during the Spanish Civil War and subsequent dictatorship. Unfortunately, eight decades on,... more
First ancient DNA from West/Central Africa illuminates deep human past  PHYS.ORG · 2 days
An international team led by Harvard Medical School scientists has produced the first genome-wide ancient human DNA sequences from west and central Africa. more
New survey results reveal the experts and public's attitude towards gene-edited crops  PHYS.ORG · 2 days
Experts' interest in utilizing gene editing for breeding crops has seen revolutionary growth. Meanwhile, people's awareness of food safety has also been increasing. To... more
New roles found for Huntington's disease protein  SCIENCE DAILY · 2 days
A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic mouse models, they have discovered that... more
Our biological clock plays crucial role in healing from surgery  SCIENCE DAILY · 2 days
If you have just had knee, shoulder or hip surgery, you may want to take anti-inflammatories in the morning or at noon, but not at night. A new... more
Cognitive function in people with mental illness  SCIENCE DAILY · 2 days
A study has shown few differences in the profiles of genes that influence cognition between people with schizophrenia, bipolar disorder and the general population. This surprising finding could provide new insights into therapies designed... more
Study sheds light on mechanisms that underlie a rare genetic condition  NEWS MEDICAL · 2 days
A team of researchers at CHU Sainte-Justine and Université de Montréal has shed light on the mechanisms that underlie a rare genetic condition by creating the... more
Ranging behavior found to impact motor self-regulation in free-range chickens  PHYS.ORG · 3 days
A team of researchers from Yncréa Hauts-de-France and Université de Tours, has found that the ranging behavior of free-range chickens can impact their motor self-regulation. In their paper... more
A heart-healthy protein from bran of cereal crop  PHYS.ORG · 3 days
Foxtail millet is an annual grass grown widely as a cereal crop in parts of India, China and Southeast Asia. Milling the grain removes the hard outer layer, or bran, from the... more
Study reveals pre-Hispanic history, genetic changes among indigenous Mexican populations  PHYS.ORG · 3 days
As more and more large-scale human genome sequencing projects get completed, scientists have been able to trace with increasing confidence both the geographical movements and underlying genetic variation... more
Urine fertilizer: 'Aging' effectively protects against transfer of antibiotic resistance  PHYS.ORG · 3 days
Recycled and aged human urine can be used as a fertilizer with low risks of transferring antibiotic resistant DNA to the environment, according to new research from the... more
Case Western researchers suggest potential Alzheimer's breakthrough  NEWS MEDICAL · 3 days
Researchers at the Case Western University School of Medicine say they have identified a previously unknown gene and associated protein which could potentially be suppressed to slow the advance of Alzheimer's disease. more
Study shows how gene therapy may help protect against vision loss in multiple sclerosis  NEWS MEDICAL · 3 days
New research by Dorothy P. Schafer, PhD, at the University of Massachusetts Medical School, reveals the molecular process in which... more
Researchers show potential link between a genetic variation and atrial fibrillation  NEWS MEDICAL · 3 days
Researchers from the Faculty of Health and Medical Sciences have shown a possible link between a genetic variation and the widespread type of cardiac arrhythmia, atrial... more
Circadian clock genes are involved in healing from surgery, study shows  NEWS MEDICAL · 3 days
If you have just had knee, shoulder or hip surgery, you may want to take anti-inflammatories in the morning or at noon, but not at night. more
Research team identifies new roles for Huntington's Disease protein  NEWS MEDICAL · 3 days
A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. more
George Mason University researchers receive $314,000 to design better vaccines  NEWS MEDICAL · 3 days
George Mason University's Aarthi Narayanan, Associate Professor, College of Science and the National Center for Biodefense and Infectious Disease, and Remi Veneziano, Assistant Professor, Volgenau School of Engineering,... more
Cardiac and visual degeneration compensated by taurine supplement  NEWS MEDICAL · 3 days
Our genome consists of 20,000 genes, all of which may be capable of triggering disease. It is estimated that there are 7,000 unknown genes that cause recessive genetic diseases resulting from mutations... more
Scientists uncover new mode of evolution  LIVE SCIENCE · 3 days
Scientists have discovered a form of natural selection that doesn't rely on DNA. more
An asteroid wiped out the dinosaurs. Then, a volcano helped life flourish.  LIVE SCIENCE · 3 days
A massive meteorite impact and extreme volcanic activity occurred around the same time that Earth's large dinosaurs went extinct. But, did the volcanic activity... more
New genetic test to predict and prevent vision loss from glaucoma  NEWS MEDICAL · 3 days
Researchers have identified 107 genes that increase a person's risk of developing the eye disease glaucoma, and now developed a genetic test to detect those at... more
Zebrafish teach researchers more about atrial fibrillation  SCIENCE DAILY · 3 days
Genetic research in zebrafish has surprised the researchers behind the study. The results have the potential to change the prevalent perception of the cardiac disorder atrial fibrillation. more
Advancing the application of genomic sequences through 'Kmasker plants'  PHYS.ORG · 3 days
The development of next-generation-sequencing (NGS) has enabled researchers to investigate genomes that might previously have been considered too complex or too expensive. Nevertheless, the analysis of complex plant genomes, which... more
Platypus on brink of extinction  SCIENCE DAILY · 3 days
New research calls for national action to minimize the risk of the platypus vanishing due to habitat destruction, dams and weirs. more
Novel artificial intelligence system reveals genes that drive tumor growth  NEWS MEDICAL · 3 days
A method for finding genes that spur tumor growth takes advantage of machine learning algorithms to sift through reams of molecular data collected from studies of cancer cell... more
Fight for Sight funds research to investigate genetic risk of age-related macular degeneration  NEWS MEDICAL · 4 days
Eye research charity Fight for Sight is funding researchers from the University of Manchester to investigate the genetic risk of the UK’s... more
Designing lasers based on quantum physics  PHYS.ORG · 5 days
A five-country research team coordinated by Germán J. de Valcárcel Gonzalvo, Professor of Optics at the University of Valencia, has developed a new theory —the coherent master equation— that describes the behavior of pulsed lasers based... more
It was microbial mayhem in the Chicxulub crater, research suggests  PHYS.ORG · 5 days
New insights into how microbial life was quickly re-established following the mass extinction of the dinosaurs have been detailed for the first time by Curtin University-led research. more
Modern face of Homo antecessor may have had insufficient room for wisdom teeth  PHYS.ORG · 5 days
A study led by the University of Bordeaux and the Dental Anthropology Group of the Centro Nacional de Investigación sobre la Evolución... more
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