Gene Editing
Proofreading the book of life: Gene editing made safer  SCIENCE DAILY · 2 days
A new method renders the gene editing tool CRISPR-Cas9 'immunosilent,' potentially allowing the editing and repair of genes to be accomplished reliably and stealthily. more
Researchers work to genetically modify flatworms and unlock their regenerative powers  PHYS.ORG · 3 days
Slice it into a hundred pieces if you want, and the millimeters-long flatworm called a planarian won't particularly care. Each piece can grow back into a... more
Proofreading the book of life: Gene editing made safer  PHYS.ORG · 3 days
The advance of science is something like the wandering of an explorer through an uncharted jungle. Often, the dense undergrowth can seem impenetrable, but at certain privileged moments, a clearing... more
New genomics tool ECCITE-seq expands multimodal single cell analysis  SCIENCE DAILY · 3 days
ECCITE-seq (Expanded CRISPR-compatible Cellular Indexing of Transcriptomes and Epitopes by sequencing) allows researchers to perform high-throughput measurements of multiple modalities of information from single cells. The technique profiles different types... more
China draws up tighter rules on human gene and embryo trials: Xinhua  REUTERS · 6 days
China's top legislature will consider tougher rules on research involving human genes and embryos, the first such move since a Chinese scientist sparked controversy... more
New method to detect off-target effects of CRISPR  SCIENCE DAILY · 6 days
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in... more
Scientists uncover a link between RNA editing and chloroplast-to-nucleus communication  PHYS.ORG · 6 days
What will a three-degree-warmer world look like? How will plants fare in more extreme weather conditions? When experiencing stress or damage from various sources, plants use chloroplast-to-nucleus communication... more
New method to detect off-target effects of CRISPR  PHYS.ORG · 6 days
Since the CRISPR genome editing technology was invented in 2012, it has shown great promise to treat a number of intractable diseases. However, scientists have struggled to identify potential off-target effects in... more
Scientists deploy CRISPR gene-editing tool to engineer multiple edits  NEWS MEDICAL · 7 days
Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments... more
Researchers use gene editing with CRISPR to treat lethal lung diseases before birth  SCIENCE DAILY · 1 week
Using CRISPR gene editing, researchers have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death... more
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq  Science Magazine · 1 week
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct... more
In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway  Science Magazine · 1 week
Although Cas9-mediated genome editing has been widely used to engineer alleles in animal models of human inherited diseases, very few homology-directed repair... more
[Research Articles] In utero gene editing for monogenic lung disease  Science Magazine · 1 week
Monogenic lung diseases that are caused by mutations in surfactant genes of the pulmonary epithelium are marked by perinatal lethal respiratory failure or chronic diffuse parenchymal lung disease... more
CRISPR base editors can induce wide-ranging off-target RNA edits  PHYS.ORG · 1 week
A Massachusetts General Hospital (MGH) research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target... more
Stanford clears faculty members in gene-edited baby inquiry  ABC NEWS · 1 week
Stanford University has cleared three faculty members of any wrongdoing in dealings with a Chinese scientist who claims to have helped make the world's first gene-edited babies more
First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway  NPR · 1 week
This could be a crucial year for the powerful gene-editing technique CRISPR as researchers start testing it in patients to treat diseases such as... more
First U.S. Patients Treated With CRISPR As Gene-Editing Human Trials Get Underway  NPR · 1 week
This could be a crucial year for the powerful gene-editing technique CRISPR as researchers start testing it in patients to treat diseases such as... more
A biosynthetic dual-core cell computer  SCIENCE DAILY · 1 week
Researchers have integrated two CRISPR-Cas9-based core processors into human cells. This represents a huge step towards creating powerful biocomputers. more
A biosynthetic dual-core cell computer  PHYS.ORG · 1 week
ETH researchers have integrated two CRISPR-Cas9-based core processors into human cells. This represents a huge step towards creating powerful biocomputers. more
Scientists Plan To Start Human Trials Testing CRISPR Soon  NPR · 1 week
The powerful gene-editing technique is moving out of the lab and into the clinic. Trials will use CRISPR to try to treat a variety of diseases, ranging from cancer and... more
CRISPR-scanning could lead to more effective treatments for cancer  NEWS MEDICAL · 1 week
11,000 people are predicted to die from acute myeloid leukemia in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to... more
Engineering 'hairpins' increases CRISPR accuracy  SCIENCE DAILY · 1 week
Biomedical engineers have developed a method for improving the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach adds a short tail to the guide RNA that folds back and binds onto itself,... more
Engineering 'hairpins' increases CRISPR accuracy  PHYS.ORG · 2 weeks
Biomedical engineers at Duke University have developed a method for improving the accuracy of the CRISPR genome editing technology by an average of 50-fold. They believe it can be easily translated to any of the editing technology's continually... more
CRISPR-Cas3 innovation holds promise for disease cures, advancing science  SCIENCE DAILY · 2 weeks
Scientists have used a new type of gene editing CRISPR system for the first time in human cells - a major advance in the field. more
Hundreds of new anti-cancer drug targets identified using CRISPR  NEWS MEDICAL · 2 weeks
A team of scientists from the Wellcome Sanger Institute have identified the genes that are essential for the survival of thirty types of cancer cells. more
New strategy for editing and repairing genetic mutation associated with microduplications  NEWS MEDICAL · 2 weeks
Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a... more
Novel strategy hits 'reset button' for disease-causing genetic duplications  SCIENCE DAILY · 2 weeks
Scientists have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway. This approach to programmable... more
CRISPR-based 'allelic drive' allows genetic editing with selective precision and broad implications  SCIENCE DAILY · 2 weeks
Scientists developed a new version of a gene drive that allows the spread of specific, favorable genetic variants, also known as 'alleles,' throughout a... more
CRISPR-based 'allelic drive' allows genetic editing with selective precision and broad implications  PHYS.ORG · 2 weeks
New CRISPR-based gene drives and broader active genetics technologies are revolutionizing the way scientists engineer the transfer of specific traits from one generation to... more
Scientists develop new CRISPR-based 'allelic drive'  NEWS MEDICAL · 2 weeks
New CRISPR-based gene drives and broader active genetics technologies are revolutionizing the way scientists engineer the transfer of specific traits from one generation to another. more
New DNA 'shredder' technique goes beyond CRISPR's scissors  SCIENCE DAILY · 2 weeks
An international team has unveiled a new CRISPR-based tool that acts more like a shredder than the usual scissor-like action of CRISPR-Cas9. The new approach, based on Type I CRISPR-Cas3, is able... more
New DNA 'shredder' technique goes beyond CRISPR's scissors  PHYS.ORG · 2 weeks
In the last six years, a tool called CRISPR-Cas9 has transformed genetic research, allowing scientists to snip and edit DNA strands at precise locations like a pair of tiny scissors. more
Researchers find a way to use CRISPR Cas-9 on reptiles  PHYS.ORG · 3 weeks
A team of researchers at the University of Georgia has found a way to use the CRISPR-Cas9 gene editing tool on reptiles. In their paper uploaded to the... more
Study demonstrates viability of gene editing strategy for recessive dystrophic epidermolysis bullosa  NEWS MEDICAL · 3 weeks
A group of researchers from the Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidad Carlos III de Madrid, the Centro de Investigaciones... more
Genome-wide analysis reveals new strategies to target pancreatic cancer  SCIENCE DAILY · 3 weeks
An international team of scientists employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the molecular dependencies - and thus vulnerabilities -- of pancreatic cancer... more
A light-based carrier system for CRISPR-Cas9 gene editing  PHYS.ORG · 3 weeks
A team of researchers from Nanjing and Xiamen Universities in China has developed an alternative to using viruses to transport CRISPR-Cas9 gene editing tools into a desired cell—and it involves two types... more
Novel strategy hits 'reset button' for disease-causing genetic duplications  PHYS.ORG · 3 weeks
Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR-Cas9 and a seldom-used DNA repair pathway.... more
New technology could change the way gene editing is approached in future  NEWS MEDICAL · 3 weeks
Gene editing has been a much sought after and controversial technology. Last month, part of the World Health Organization called for an international registry... more
New protein for gene editing may improve disease treatment, sustainable manufacturing  SCIENCE DAILY · 3 weeks
Researchers have developed a method that uses the protein Argonaute from Natronobacterium gregoryi (NgAgo) and supplied DNA for gene editing. more
Near-infrared upconversion-activated CRISPR-Cas9 system: A remote-controlled gene editing platform  Science Magazine · 3 weeks
As an RNA-guided nuclease, CRISPR-Cas9 offers facile and promising solutions to mediate genome modification with respect to versatility and high precision. However, spatiotemporal manipulation of CRISPR-Cas9 delivery remains a daunting... more
New protein for gene editing may improve disease treatment, sustainable manufacturing  PHYS.ORG · 3 weeks
Gene editing has been a much sought after and controversial technology. Last month, part of the World Health Organization called for an international registry to track... more
A Nobel Prize winner argues banning CRISPR babies won’t work  SCIENCE-NEWS · 3 weeks
Human gene editing needs responsible regulation, but a ban isn’t the way to go, says Nobel laureate David Baltimore. more
New plant breeding technologies for food security  PHYS.ORG · 4 weeks
An international team, including researchers from the University of Göttingen, argues in a perspective article recently published in Science that new plant breeding technologies can contribute significantly to food security and sustainable development. Genome... more
New plant breeding technologies for food security  SCIENCE DAILY · 4 weeks
Scientists argue that new plant breeding technologies can contribute significantly to food security and sustainable development. Genome editing techniques in particular, such as CRISPR/Cas, could help to make agriculture more productive and environmentally friendly.... more
Introducing a kinder, gentler way to blow holes in cells  PHYS.ORG · 4 weeks
When scientists attempt to slip big molecules, like the Cas9 enzyme that is key to CRISPR gene editing, into cells, things can get messy. more
Researchers develop new strategy to treat sickle cell disease and beta thalassemia  NEWS MEDICAL · 4 weeks
Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the University of Massachusetts Medical School have developed a strategy to treat two of... more
Interest in RNA editing heats up  PHYS.ORG · 4 weeks
The gene-editing technology known as CRISPR has attracted much excitement and investor interest with its potential to someday treat diseases by fixing faulty copies of genes. But recently, a different approach called RNA editing, which could... more
Record-breaking gene edit disables 13,200 LINE-1 Transposons in a single cell  PHYS.ORG · 4 weeks
An international team of researchers has succeeded in making 13,200 edits to a single cell—and the cell survived. In their paper uploaded to the bioRxiv preprint... more
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