DNA
World's oldest human DNA found in 800,000-year-old tooth of a cannibal  LIVE SCIENCE · 1 day
A protein analysis of an 800,000-year-old tooth suggests the supposed cannibal species Homo antecessor was only distantly related to humans and Neanderthals. more
Homo sapiens Interbred with Various Neanderthal Populations, Study Says  SCI-NEWS.COM · 2 days
Modern humans in Eurasia carry genetic material inherited from Altai Neanderthals, according to a study published in the journal... more
Newly discovered biostability in DNA structures may lead to enhanced design of therapeutics  nanowerk · 2 days
Researchers discovered an already existing biostable DNA motif applicable to the design of new drug carriers and diagnostics. more
Structural basis for allosteric PARP-1 retention on DNA breaks  Science Magazine · 2 days
The success of poly(ADP-ribose) polymerase–1 (PARP-1) inhibitors (PARPi) to treat cancer relates to their ability to trap PARP-1 at the site of a DNA break. Although different forms of PARPi... more
Technique reveals how crystals form on surfaces  MIT · 3 days
DNA-based self-assembling system sheds light on processes essential for semiconductors and nanotechnology. more
How (easily) does the novel coronavirus spread?  NEWS MEDICAL · 3 days
Viruses are tiny bundles of DNA or RNA which have the ability to infect host cells, hijack the machinery of the host cell and then replicate. Once the host cell’s resources are exhausted, the... more
Modern humans, Neanderthals share a tangled genetic history, study affirms  SCIENCE DAILY · 3 days
A new study reinforces the concept that Neanderthal DNA has been woven into the modern human genome on multiple occasions as our ancestors met Neanderthals time and again... more
First complete German shepherd DNA offers new tool to fight disease  PHYS.ORG · 3 days
Scientists have mapped the genome of the German shepherd, one of the world's most popular canine breeds, after using a blood sample from 'Nala,' a healthy... more
A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application  Science Magazine · 3 days
Although growth factors have great therapeutic potential because of their regenerative functions, they often have intrinsic drawbacks, such as low... more
Using sound and environmental DNA to find an elusive, endangered whale  PHYS.ORG · 4 days
In an ongoing effort to detect endangered Bryde's whales, the National Oceanic and Atmospheric Administration (NOAA) and MBARI have teamed up to deploy an Environmental Sample... more
Scientists unravel a new mechanism that triggers cell death and inflammation  NEWS MEDICAL · 4 days
Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic... more
Cobra Biologics and Karolinska Institutet join forces to develop DNA vaccine against COVID-19  NEWS MEDICAL · 4 days
Cobra Biologics, an international CDMO for biologics and pharmaceuticals, and the Karolinska Institutet, one of the world’s leading medical universities, today announced... more
Novel approach to DNA synthesis could help tackle COVID-19 pandemic  NEWS MEDICAL · 4 days
Synthetic biology, and particularly DNA synthesis, is transforming diagnosis and treatment of disease, and may yet play a key role in halting the COVID-19 pandemic. more
New blood test accurately detects more than 50 types of cancer  NEWS MEDICAL · 5 days
Researchers have developed a blood test that could accurately detect up to 50 types of cancers, and some of these detections could be even before the... more
Newly discovered enzyme “square dance” helps generate DNA building blocks  MIT · 5 days
MIT biochemists can trap and visualize an enzyme as it becomes active — an important development that may aid in future drug development. more
DNA riddle unravelled: How cells access data from 'genetic cotton reels'  SCIENCE DAILY · 1 week
With so much genetic information packed in such a tiny space, how cells access DNA when it needs it is something of a mystery. Research has... more
Capabilities of CRISPR gene editing expanded  PHYS.ORG · 1 week
Many basic and clinical researchers are testing the potential of a simple and efficient gene editing approach to study and correct disease-causing mutations for conditions ranging from blindness to cancer, but the technology is constrained by... more
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants  Science Magazine · 1 week
Manipulation of DNA by CRISPR-Cas enzymes requires the recognition of a protospacer adjacent motif (PAM), limiting target site recognition to a subset of sequences. To remove this constraint, we engineered variants of... more
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex  Science Magazine · 1 week
Ribonucleotide reductases (RNRs) are a diverse family of enzymes that are alone capable of generating 2'-deoxynucleotides de novo and are thus critical in DNA... more
Scientists reveal how proteins team up to repair DNA  SCIENCE DAILY · 2 weeks
Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research. more
Scientists reveal how proteins team up to repair DNA  PHYS.ORG · 2 weeks
Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research published today in eLife. more
Research reveals important mechanism in the repair of DNA double-strand breaks  NEWS MEDICAL · 2 weeks
Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research published today in eLife. more
eDNA provides researchers with 'more than meets the eye'  SCIENCE DAILY · 2 weeks
Researchers have used next generation DNA sequencing to learn more about the different species of plants, insects and animals present in the Pilbara and Perth regions of Western Australia. more
DNA riddle unravelled: How cells access data from 'genetic cotton reels'  PHYS.ORG · 2 weeks
Australian scientists have unraveled part of the mystery about how nature can usefully access genetic information in cells despite it being so tightly packed away. more
Crumpled graphene can be used to make ultra-sensitive cancer DNA detector  NEWS MEDICAL · 2 weeks
Crumpled graphene can enhance graphene-based biosensors, increasing sensitivity to DNA for accurate detection of cancer. more
eDNA provides researchers with 'more than meets the eye'  PHYS.ORG · 2 weeks
Researchers from Curtin University have used next generation DNA sequencing to learn more about the different species of plants, insects and animals present in the Pilbara and Perth regions of... more
Protein modification with ISG15 blocks coxsackievirus pathology via antiviral and metabolic reprogramming  PHYS.ORG · 2 weeks
During early encounters between a pathogen and a cell, receptors located on the cell surface, in the cytosol or within endosomal (storage) compartments engage... more
Crumpled graphene makes ultra-sensitive cancer DNA detector  nanowerk · 2 weeks
Crumpling graphene makes it more than ten thousand times more sensitive to DNA by creating electrical 'hot spots'. more
Crumpled graphene makes ultra-sensitive cancer DNA detector  PHYS.ORG · 2 weeks
Graphene-based biosensors could usher in an era of liquid biopsy, detecting DNA cancer markers circulating in a patient's blood or serum. But current designs need a lot of DNA. In a new study, crumpling... more
Crumpled grapheme can be more sensitive in detecting DNA cancer markers  NEWS MEDICAL · 2 weeks
Graphene-based biosensors could usher in an era of liquid biopsy, detecting DNA cancer markers circulating in a patient's blood or serum. But current designs need a... more
Study identifies ancestral fragments of DNA associated with hereditary prostate cancer  NEWS MEDICAL · 2 weeks
Vanderbilt researchers have identified haplotypes, ancestral fragments of DNA, that are associated with hereditary prostate cancer (HPC) in a first-of-its-kind genomic study made possible by the... more
Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia  NEWS MEDICAL · 2 weeks
A study found that children with aggressive blood cancers have different superstructures of the proteins that control gene access. more
Harnessing human genetics to uncover clues to longevity  NEWS MEDICAL · 2 weeks
The genetic code within DNA has long been thought to determine whether one becomes sick or resists illnesses. DNA contains the information that makes all cells that compose our bodies and allows... more
New role of important factor in early embryonic development identified  PHYS.ORG · 2 weeks
In collaboration with Stanford University, a working group from MedUni Vienna's Division of Cell and Developmental Biology, led by Mark Wossidlo, has identified the role of a factor... more
Epigenetic inheritance: A 'silver bullet' against climate change?  PHYS.ORG · 2 weeks
The current pace of climate change exceeds historical events by 1-2 orders of magnitude, which will make it hard for organisms and ecosystems to adapt. For a long time, it has been... more
Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage  Science Magazine · 2 weeks
Zinc finger protein Zscan4 is selectively expressed in mouse two-cell (2C) embryos undergoing zygotic genome activation (ZGA) and in a rare subpopulation... more
MILabs enhances preclinical diagnostic U-CT system for COVID-19 research  NEWS MEDICAL · 2 weeks
Based on recent scientific research, diagnostic X-ray CT is able to detect COVID-19, the disease caused by the novel coronavirus (SARS-CoV-2), in individuals with high clinical suspicion of the virus... more
Bacteria cause problems for genetic research  SCIENCE DAILY · 2 weeks
A puzzling modification of DNA that is typical in bacteria does not occur in humans or other mammals. This has been shown in a new study. The study shows that findings from the epigenetic marker 6mdA... more
New technique 'prints' cells to create diverse biological environments  nanowerk · 2 weeks
Researchers have created a new technique that utilizes photolithography and programmable DNA to rapidly 'print' two-dimensional arrays of cells and proteins that mimic a wide variety of cellular environments in... more
New technique 'prints' cells to create diverse biological environments  SCIENCE DAILY · 2 weeks
With the help of photolithography and programmable DNA, researchers have created a new technique that can rapidly 'print' two-dimensional arrays of cells and proteins that mimic a wide variety of... more
Supercomputers unlock reproductive mysteries of viruses and life  SCIENCE DAILY · 2 weeks
Supercomputer simulations support a new mechanism for the budding off of viruses like the coronavirus. ESCRTIII polymer features clear intrinsic twist in molecular dynamics simulations, might play major role in creating three-dimensional... more
Bacteria cause problems for genetic research  PHYS.ORG · 2 weeks
A puzzling modification of DNA that is common in bacteria is not present in humans or other mammals. This has been shown in a new study by scientists at Linköping University in Sweden, published in Science... more
Novel Alzheimer's risk genes affect microglial response to amyloid-beta  NEWS MEDICAL · 2 weeks
Our DNA determines a large part of our risk for Alzheimer's disease, but it remained unclear how many genetic risk factors contribute to disease. more
No evidence for DNA N6-methyladenine in mammals  Science Magazine · 2 weeks
N6-methyladenine (6mdA) is a widespread DNA modification in bacteria. More recently, 6mdA has also been characterized in mammalian DNA. However, measurements of 6mdA abundance and profiles are often very dissimilar between studies, even when... more
[Research Articles] A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection  Science Magazine · 2 weeks
Accurate and noninvasive monitoring of renal allograft posttransplant is essential for early detection of acute rejection (AR) and... more
Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach  Science Magazine · 2 weeks
Elucidating how the spatial organization of extrinsic signals modulates cell behavior and drives biological processes remains largely unexplored because of challenges in controlling spatial patterning of multiple microenvironmental... more
How 'pioneer' protein turns stem cells into organs  PHYS.ORG · 2 weeks
Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new... more
Amplification and imaging of microRNA as a biomarker to detect tumor development  nanowerk · 3 weeks
Scientists found a way to amplify miRNA in live tumor cells for bioimaging. Their assay is based on a robust cellular autocatalytic biocircuit triggered... more
New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus  SCIENCE DAILY · 3 weeks
Researchers have developed a new kind of CRISPR screen technology to target RNA. The team leveraged their technology for a critical analysis:... more
Elucidation of mechanisms that coordinate cell memory inheritance with DNA replication  PHYS.ORG · 3 weeks
Why do normal cells turn into cancer cells? One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.... more
Researchers elucidate new mechanism for controlling DNA methylation in cells  NEWS MEDICAL · 3 weeks
Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation. more
Scientists can now edit multiple genome fragments at a time  PHYS.ORG · 3 weeks
Scientists can now edit multiple sites in the genome at the same time to learn how different DNA stretches co-operate in health and disease. more
New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus  PHYS.ORG · 3 weeks
CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many... more
Amplification and imaging of microRNA as a biomarker to detect tumor development  PHYS.ORG · 3 weeks
A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered... more
Highly efficient, low-cost method developed to reduce DNA errors  PHYS.ORG · 3 weeks
DNA only persists through replication—naturally or synthetically. While humans need the genetic material to be reproduced in order to replace old or damaged cells, the ability to replicate DNA in... more
Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination-mediated DNA repair  Science Magazine · 3 weeks
Previously, we reported that chromodomain Y–like (CDYL) acts as a crotonyl–coenzyme A hydratase and negatively regulates histone crotonylation (Kcr). However, the global CDYL-regulated crotonylome remains unclear.... more
Environmental DNA in rivers offers new tool for detecting wildlife communities  PHYS.ORG · 3 weeks
Ecologists in England and Scotland, collaborating with ecologists Christopher Sutherland and Joseph Drake at the University of Massachusetts Amherst, report this week on a new method... more
Environmental DNA in rivers offers new tool for detecting wildlife communities  SCIENCE DAILY · 3 weeks
Ecologists report this week on a new method of identifying an 'entire community of mammals' -- including elusive and endangered species that are otherwise difficult to... more
Researchers map structure of key chromatin-remodeling complex  PHYS.ORG · 3 weeks
Northwestern University researchers have mapped a group of proteins that play a critical role in both gene expression and repairing damaged DNA. By understanding this protein complex, called SWI/SNF, researchers hope to better understand... more
Blood test for microbial DNA could warn of cancer  NEWS MEDICAL · 3 weeks
A new study published in the journal Nature on March 11, 2020, could transform the currently held views on cancer causation and diagnosis. The researchers have come up with a... more
Microbial DNA in the blood could help identify who has cancer  NEWS MEDICAL · 3 weeks
When Gregory Poore was a freshman in college, his otherwise healthy grandmother was shocked to learn that she had late-stage pancreatic cancer. The condition was diagnosed... more
Caught in a spin: Spiral vortex streamlines delivery of nanomaterials into cells  PHYS.ORG · 4 weeks
The membrane surrounding cells acts as a selective barrier, cradling and protecting the cell's contents from the external surroundings and choosing which substances to... more
Second Patient Cured of HIV, Researchers Say  SCI-NEWS.COM · 3 weeks
A study of the ‘London patient’ — the second HIV patient to undergo stem cell transplantation from donors with a HIV-resistant gene... more
New study unveils the mechanism of DNA high-order structure formation  PHYS.ORG · 4 weeks
A joint research team led by Professor Ja Yil Lee (School of Life Sciences, UNIST) and Professor Ji-Joon Song (Department of Biological Sciences, KAIST) has unveiled the structure... more
Protecting DNA origami for anti-cancer drug delivery  PHYS.ORG · 4 weeks
Scientists have designed and synthesized chains of molecules with a precise sequence and length to efficiently protect 3-D DNA nanostructures from structural degradation under a variety of biomedically relevant conditions. They demonstrated how these... more
Researchers establish new viable CRISPR-Cas12b system for plant genome engineering  PHYS.ORG · 4 weeks
In a new publication in Nature Plants, assistant professor of Plant Science at the University of Maryland Yiping Qi has established a new CRISPR genome engineering system as... more
New study unveils the mechanism of DNA high-order structure formation  SCIENCE DAILY · 4 weeks
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has unveiled the structure and mechanism of proteins that are highly overexpressed in... more
New toolkit to repair DNA breaks linked to aging, cancer and MND discovered  NEWS MEDICAL · 4 weeks
A new 'toolkit' to repair damaged DNA that can lead to aging, cancer and Motor Neurone Disease has been discovered by scientists... more
Geneticists pump the brakes on DNA, revealing key developmental process  PHYS.ORG · 4 weeks
Researchers at Princeton University have revealed the inner workings of a gene repression mechanism in fruit fly embryos, adding insight to the study of human diseases. more
New technique to distinguish freshly made transcripts from pre-existing transcripts  NEWS MEDICAL · 4 weeks
Our bodies consist of trillions of cells that all contain the same DNA. Even though the DNA in each cell is the same, we consist of many different... more
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