Cancer
Starving pancreatic cancer cells of cysteine may induce tumor ferroptosis  NEWS MEDICAL · 12 hours
A new study from Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center suggests a compound in development for a rare kidney stone disease may... more
New study overturns ‘snapshot’ model of cell cycle accepted since 1974  NEWS MEDICAL · 12 hours
Cells have a big decision: Should they replicate or sleep? Healthy cells can go either way. Cancer cells' replication switches are stuck in the 'on' position. more
Cysteine depletion induces pancreatic tumor ferroptosis in mice  Science Magazine · 17 hours
Ferroptosis is a form of cell death that results from the catastrophic accumulation of lipid reactive oxygen species (ROS). Oncogenic signaling elevates lipid ROS production in many tumor types and is counteracted... more
Structural basis for allosteric PARP-1 retention on DNA breaks  Science Magazine · 17 hours
The success of poly(ADP-ribose) polymerase–1 (PARP-1) inhibitors (PARPi) to treat cancer relates to their ability to trap PARP-1 at the site of a DNA break. Although different forms of PARPi... more
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1  Science Magazine · 17 hours
Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish... more
A 3-D-printed brain could make it easier to find cancer treatments  PHYS.ORG · 21 hours
Glioblastoma is the deadliest form of brain tumor—less than 10 percent of people who are diagnosed with it will survive more than five years. more
Breast density, microcalcifications, and masses are heritable features, analysis reveals  NEWS MEDICAL · 1 day
An analysis of a large Swedish cohort revealed that breast density, microcalcifications, and masses are heritable features, and that breast density and microcalcifications were positively associated with a... more
Majority of patients with mantle cell lymphoma may benefit from CAR T-cell therapy KTE-X19  NEWS MEDICAL · 1 day
A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with... more
Hereditary genetic defect linked to medulloblastoma destabilizes protein regulation  NEWS MEDICAL · 1 day
The causes of 40 percent of all cases of certain medulloblastoma - dangerous brain tumors affecting children - are hereditary. more
Immunotherapy may benefit mCRPC patients with specific markers of immune activation  NEWS MEDICAL · 1 day
Although metastatic castration-resistant prostate cancer typically has limited response to immunotherapy, a subset of patients with pretreatment evidence of active T-cell responses in their tumors experienced... more
Significant global investment in treating children with cancer could save 11 million lives  NEWS MEDICAL · 1 day
A significant, sustained, global investment in treating children with cancer could save 11 million lives and yield a triple return on investment,... more
Understanding hereditary medulloblastomas in children  NEWS MEDICAL · 2 days
This is a combined press release between EMBL, the Hopp Children's Cancer Center Heidelberg and the German Cancer Consortium. more
Inherited gene mutation can predispose children to SHH medulloblastoma  NEWS MEDICAL · 2 days
Investigators at St. Jude Children's Research Hospital, the European Molecular Biology Laboratory, and the German Cancer Research Center have identified ELP1 as a novel predisposition gene in the SHH subgroup... more
New sensors could offer early detection of lung tumors  MIT · 2 days
Study shows that a simple urine test can reveal the presence of lung cancer in mice. more
Pretargeted delivery of PI3K/mTOR small-molecule inhibitor-loaded nanoparticles for treatment of non-Hodgkins lymphoma  Science Magazine · 2 days
Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual PI3K/mTOR inhibitor, but it was withdrawn from early-phase... more
[Research Articles] Control of brain tumor growth by reactivating myeloid cells with niacin  Science Magazine · 2 days
Glioblastomas are generally incurable partly because monocytes, macrophages, and microglia in afflicted patients do not function in an antitumor capacity. Medications that... more
[Research Articles] Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling  Science Magazine · 2 days
Lung cancer is the leading cause of cancer-related death, and patients most commonly present with incurable advanced-stage disease. U.S. national... more
Understanding brain tumors in children  SCIENCE DAILY · 2 days
The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of... more
FDA wants heartburn meds off the market due to contamination  ABC NEWS · 2 days
The U.S. Food and Drug Administration is telling drugmakers to immediately pull a type of heartburn drug off the market due to contamination with a chemical that may... more
The discovery of new compounds for acting on the circadian clock  PHYS.ORG · 2 days
The circadian clock controls a variety of biological phenomena that occur during the course of the day, such as sleeping and waking. Perturbation of the circadian... more
New collaboration may lead to future clinical trials to test treatment for leukemia  NEWS MEDICAL · 2 days
In a new pre-clinical study published this week in the journal Leukemia, the research team of Children's Hospital Los Angeles investigator Hisham... more
ERC awards grants to 158 European scientists to identify effective immunotherapy strategies for cancer  NEWS MEDICAL · 2 days
The European Research Council (ERC) has announced it will support Professor Thomas Blankenstein to the tune of €2.5 million over... more
Researchers identify new therapeutic strategies against cancer  NEWS MEDICAL · 2 days
New findings open up to new therapeutic strategies against cancer.IGC researchers identify signals emitted by the tumor environment, which controls the migrating capacity of cancer cells. more
Study examines the effect of Medicaid expansion on head and neck cancer patients  NEWS MEDICAL · 2 days
A study published in the JAMA Otolaryngology-Head & Neck Surgery examines the effect of Medicaid expansion on head and neck cancer patients,... more
Novel immunotherapy eradicates solid tumors in mice without adverse side effects  NEWS MEDICAL · 3 days
Scientists have developed a new immunotherapy that eradicates solid tumors in mice without adverse side effects, according to a new study published today in eLife. more
New viable therapeutic strategy found for ER+ breast cancer  NEWS MEDICAL · 3 days
Researchers say they have found a viable new therapeutic strategy for estrogen receptor-positive (ER+) breast cancer, even cancers that are resistant to current standard of care treatments. more
Potential new method of breast cancer treatment using androgen receptor  NEWS MEDICAL · 3 days
Scientists may have discovered a new therapeutic approach to treat ER+ breast cancer using androgen receptor-stimulating drugs. more
New blood test detects more than 50 types of cancer, including at early, more treatable stages  NEWS MEDICAL · 3 days
Researchers have developed a simple blood test that can detect over 50 types of cancer, often... more
Researchers reveal mechanism of trimming longer RNA transcripts to become micro RNA  PHYS.ORG · 3 days
A particular group of non-coding RNAs (ncRNAs) known as microRNAs (miRNAs) are ~22 nucleotide (nt) in length and play vital roles in diverse physiological... more
Researchers discover molecule's unusual cell-killing mechanism  PHYS.ORG · 3 days
Soon after Jake Eaton joined the lab of Stuart Schreiber at the Broad Institute of MIT and Harvard in 2015, the postdoctoral researcher became intrigued by some wild theories being debated by his colleagues. The theories... more
UVA researchers find way to enhance cancer outcomes by examining patients' genetic data  NEWS MEDICAL · 3 days
By mining a vast trove of genetic data, researchers at the University of Virginia School of Medicine are enhancing doctors’ ability to... more
New blood test accurately detects more than 50 types of cancer  NEWS MEDICAL · 3 days
Researchers have developed a blood test that could accurately detect up to 50 types of cancers, and some of these detections could be even before the... more
Blood test detects over 50 types of cancer, some before symptoms appear  SCIENCE DAILY · 3 days
In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within... more
Research shows significant difference in radiation response between sexes  NEWS MEDICAL · 3 days
Women undergoing radiotherapy for many cancers are more likely than men to be cured, but the side effects are more brutal, according to one of Australia's most experienced radiation oncology... more
Oral apixaban as effective as dalteparin for treating blood clots in people with cancer  NEWS MEDICAL · 4 days
For people with cancer, the oral blood thinner apixaban is at least as effective as dalteparin, a low molecular weight... more
Mount Sinai researchers figure out how to ramp up immune system to prevent tumor growth  NEWS MEDICAL · 4 days
Mount Sinai researchers have discovered a pathway that regulates special immune system cells in lung cancer tumors, suppressing... more
World's only online image-based tool to improve COVID-19 diagnosis launched  NEWS MEDICAL · 4 days
The world's only online image-based COVID-19 diagnosis improvement tool for healthcare workers is launched today by University of Sydney spinoff DetectED-X, drawing on its global experience and outcomes... more
Moffitt scientists identify potential therapeutic targets for cutaneous squamous cell carcinoma  NEWS MEDICAL · 4 days
Cutaneous squamous cell carcinoma (cuSCC) is the second most common diagnosed malignancy in the United States, with approximately 700,000 new cases each year. more
Researchers find way to improve cancer outcomes by examining patients' genes  SCIENCE DAILY · 4 days
Genetics researchers say a new approach could benefit all sorts of serious health conditions, and they're urging scientists to quickly pluck 'low hanging fruit' for the... more
Hidden messages in protein blueprints  PHYS.ORG · 4 days
Scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM) and the Max Planck Institute in Freiburg have identified a new control mechanism that enables stem cells to... more
Research could open up new therapeutic strategies for some lung and kidney cancers  NEWS MEDICAL · 4 days
New findings from researchers at The University of Texas MD Anderson Cancer Center about how some cancer cells become "addicted" to glucose... more
Weakness in lung and kidney cancer cells could serve as therapeutic target  NEWS MEDICAL · 4 days
An important discovery about how some cancers rely on glucose to survive could lead to development of tumor-specific treatments. more
Researchers make first direct measurement of the physical force of invading cancer cells  PHYS.ORG · 4 days
International research led by the University of St Andrews reveals the first direct measurement of the force cancer cells can apply when they... more
Research characterizes iPS87 cell line as cancer-inducing, stem cell-like cell line  NEWS MEDICAL · 6 days
Oncotarget Volume 11, Issue 12 reported outside its natural niche, the cultured prostate cancer stem cells lost their tumor-inducing capability and stem cell marker expression after... more
Size of tumor tissue area crucial for reliable cancer prognosis, study shows  NEWS MEDICAL · 7 days
The method of choice used for preparing tissue samples can lead to biased results in the analysis of cancer patient survival. more
Disasters can affect cervical cancer screening for years  SCIENCE DAILY · 7 days
Screening is important for the early detection of cervical cancer, but rates were significantly affected, in some areas for years, following a devastating earthquake and tsunami in Japan. more
Microbiome may hold key to identifying HPV-infected women at risk for pre-cancer  SCIENCE DAILY · 7 days
Gardnerella bacteria in the cervicovaginal microbiome may serve as a biomarker to identify women infected with human papillomavirus (HPV) who are at risk for... more
New approach shows promise as a treatment for chemo-resistant ovarian cancer  NEWS MEDICAL · 7 days
Researchers have made a discovery about the behavior of ovarian cancer cells that could lead to a new treatment approach. more
A promising strategy to overcome drug resistance developed by blood cancer cells  NEWS MEDICAL · 7 days
In a collaborative study published in Blood Advances, a research group led by Beate Heissig at Juntendo University and Yousef Salama at An Najah... more
Capabilities of CRISPR gene editing expanded  PHYS.ORG · 7 days
Many basic and clinical researchers are testing the potential of a simple and efficient gene editing approach to study and correct disease-causing mutations for conditions ranging from blindness to cancer, but the technology is constrained by... more
New framework to help guide decisions for prostate cancer radiotherapy during COVID-19 pandemic  NEWS MEDICAL · 7 days
In the wake of the COVID-19 pandemic, a team of radiation oncologists from the U.S. and U.K. is recommending a new framework... more
Disasters have a major impact on cervical cancer screening for years  NEWS MEDICAL · 1 week
Cervical cancer screening rates in Japan were significantly affected in the years following the devastating Great East Japan Earthquake of 2011, Tohoku University scientists report in... more
Microbiome could help identify pre-cancer risk in women with HPV  NEWS MEDICAL · 1 week
A new study published in the open-access journal PLOS Pathogens in March 2020 reports the possible use of the bacteria Gardnerella found in the cervix and vagina of... more
Adverse childhood experiences associated with executive dysfunction post-surgical menopause  NEWS MEDICAL · 1 week
Assessing adverse childhood experiences and current anxiety and depression symptoms may help ease cognitive distress in women who have undergone a surgical menopause for cancer risk-reduction, or RRSO, according to... more
Targeting specific histone deacetylase may be novel therapeutic strategy for NSCLC  NEWS MEDICAL · 1 week
The survival rates for patients with non-small cell lung cancer have improved greatly over the past decade thanks to several new targeted treatment options for patients. more
Experimental heart disease drug may treat chemo-resistant ovarian cancer  NEWS MEDICAL · 1 week
Most ovarian cancer starts in fallopian tubes. Then it sloughs from its site of origin and floats around in fluid until finding new sites of attachment. It's not easy for... more
Highly focused radiation may slow disease progression in men with oligometastatic prostate cancer  NEWS MEDICAL · 1 week
Highly focused, intense doses of radiation called stereotactic ablative radiation (SABR) may slow progression of disease in a subset of men with... more
New type of immunotherapy shows promise for future treatment of ovarian cancer  NEWS MEDICAL · 1 week
Malignant ovarian cancer is insidious: Known and feared for vague and uncharacteristic symptoms that often mean the disease is discovered so late that on... more
The evolutionary dynamics and fitness landscape of clonal hematopoiesis  Science Magazine · 1 week
Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance remains largely... more
Insights into diagnosis and treatment of rare pediatric brain cancer  NEWS MEDICAL · 1 week
Ependymoma is a rare form of brain cancer that implicates children and is often tricky to diagnose. more
Despite failures, chemo still promising against dangerous childhood brain cancer, DIPG  SCIENCE DAILY · 1 week
The pediatric brain cancer known as diffuse intrinsic pontine glioma (DIPG) is almost uniformly fatal. In part, this is due to where and how it grows,... more
Intense and targeted radiotherapy could slow progression of certain prostate cancers  NEWS MEDICAL · 1 week
Targeted and strong doses of stereotactic ablative radiation (SABR) radiotherapy could slow progression in prostate cancer. more
Novel hybrid nanocomposite sheds light on therapy of deep-seated orthotopic lung tumors  nanowerk · 1 week
The nanocomposite was developed through the assembly of gold nanobipyramids on black phosphorus nanosheets. This nanocomposite could simultaneously enhance singlet oxygen generation and hyperthermia... more
Transmission of COVID-19 among cancer patients in China  NEWS MEDICAL · 1 week
Researchers from Zhongnan Hospital of Wuhan University in China in collaboration with those from the National Cancer Centre Singapore, have come up with a study that reveals the transmission of the SARS-CoV-2... more
Study shows disparities in guideline-concordant treatment for NSCLC patients  NEWS MEDICAL · 1 week
Lung cancer is the leading cause of cancer-associated deaths in the United States. Non-small cell lung cancer (NSCLC), a group of lung cancers named for the kinds of cells found... more
Despite failures, chemotherapy still promising against fatal pediatric brain cancer  NEWS MEDICAL · 1 week
The pediatric brain cancer known as diffuse intrinsic pontine glioma is almost uniformly fatal. In part, this is due to where and how it grows, forming as a... more
Overexpression of hPCL3S could contribute to tumor progression in prostate cancer  NEWS MEDICAL · 1 week
The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone... more
Advancing CAR T-cell therapy for treatment of solid tumors  NEWS MEDICAL · 1 week
The full title of the research is "The study of the mechanisms of effectiveness of T-cells CAR-T towards solid tumors"; it was supported by nonprofit RakFond (Cancer Fund) and CyStoreLab... more
A nanoscale device to generate high-power Terahertz waves  SCIENCE DAILY · 1 week
Researchers have developed a nanodevice that operates more than 10 times faster than today's fastest transistors. It enables the generation of high-power terahertz waves. These waves, which are notoriously difficult to produce,... more
Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming  Science Magazine · 1 week
Radiotherapy (RT) is routinely used in cancer treatment, but expansion of its clinical indications remains challenging. The mechanism underlying the radiation-induced bystander... more
Lung cancer medication may have benefits for patients with metastatic brain cancers  NEWS MEDICAL · 1 week
A medication commonly used to treat non-small cell lung cancer that has spread, or metastasized, may have benefits for patients with metastatic brain cancers,... more
Combination produces more proliferative, enduring central memory T cells for cellular therapy  NEWS MEDICAL · 1 week
Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab... more
Ultrafast repeated staining and destaining of cell samples for tumor diagnostics  PHYS.ORG · 1 week
In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. In the... more
Ultrafast repeated staining and destaining of cell samples for tumor diagnostics  SCIENCE DAILY · 1 week
In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. Scientists have... more
New molecular probes for opioid receptors  PHYS.ORG · 1 week
Strong painkillers are very important in the management of patients with cancer and heart attack or requiring surgery. They extert their effect by binding to so-called opioid receptors in the body. more
Cancer could potentially be treated with new immunotherapy approach, say researchers  NEWS MEDICAL · 1 week
Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer. more
Researchers investigate how cellular protein shredders can be programmed to fight cancer  NEWS MEDICAL · 1 week
An international team of researchers led by the Universities of Bonn and Ulm has investigated how a cell's own "protein shredder" can be specifically... more
YAP signal pathway plays a vital role in the onset of head-and-neck cancer  NEWS MEDICAL · 1 week
Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal... more
Supercomputer helps benchmark new molecular docking tool  NEWS MEDICAL · 1 week
With the American Cancer Society estimating 1.76 million new cases and more than 600,000 deaths during 2019 in the U.S. alone, cancer remains a critical healthcare challenge. more
Changes in surface sugarlike molecules help cancer cells to spread  NEWS MEDICAL · 1 week
Changes in a specific type of sugarlike molecule, or glycan, on the surface of cancer cells help them to spread into other tissues, according to researchers at the... more
Quality of diet among young Americans remains poor  NEWS MEDICAL · 1 week
Poor diet is a significant contributor to chronic diseases, including cardiovascular disease, cancer, obesity, and diabetes accounting for early mortality. A new study published in the journal JAMA in March 2020 shows... more
Changes in surface sugarlike molecules help cancer metastasize  PHYS.ORG · 1 week
Changes in a specific type of sugarlike molecule, or glycan, on the surface of cancer cells help them to spread into other tissues, according to researchers at the University of California, Davis.... more
Penn State engineers model genetic mutations causing drug resistance  NEWS MEDICAL · 1 week
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and... more
Engineers model mutations causing drug resistance  SCIENCE DAILY · 1 week
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and 'second generation' approaches are needed. Now,... more
Engineers model mutations causing drug resistance  PHYS.ORG · 1 week
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and "second generation" approaches are needed. Now,... more
Immunotherapy using 'young cells' offers promising option against cancer  SCIENCE DAILY · 1 week
A new study suggests that the age of certain immune cells used in immunotherapy plays a role in how effective it is. These cells -- natural killer (NK) cells --... more
Crumpled graphene can be used to make ultra-sensitive cancer DNA detector  NEWS MEDICAL · 1 week
Crumpled graphene can enhance graphene-based biosensors, increasing sensitivity to DNA for accurate detection of cancer. more
Crumpled graphene makes ultra-sensitive cancer DNA detector  nanowerk · 1 week
Crumpling graphene makes it more than ten thousand times more sensitive to DNA by creating electrical 'hot spots'. more
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