In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper like transcription regulator 1 (LZTR1) gene led...
The general transcription factor IID (TFIID) is a critical component of the eukaryotic transcription preinitiation complex (PIC) and is responsible for recognizing the core...
The LZTR1 protein, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, is implicated in human disease, yet its mechanism of action remains unknown. We found that Lztr1...
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG...
Diet affects multiple facets of human health and is inextricably linked to chronic metabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease. Dietary nutrients...
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic...
One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry,...
The gut bacteria of four Himalayan populations differ based on their dietary lifestyles, according to a new study by researchers at the Stanford University School of...
Genetically engineered microbes such as bacteria and yeasts have long been used as living factories to produce drugs and fine chemicals. More recently, researchers have started to combine bacteria with semiconductor technology that, similar to solar...
Creating fire buffers between housing and dry brush, burying spark-prone power lines and lighting more controlled burns to keep vegetation in check could give people a better chance of surviving...
The already-rare Stone's sheep of the Yukon is 20 per cent less common than previously thought, according to new research by University of Alberta biologists.
Researchers have studied flight routes to determine how far willow warblers migrate in the autumn. The results show that the willow warbler holds a long-distance migration record in the 10-gram weight category -- with the small birds flying...
When healthy people eat a low-gluten and fiber-rich diet compared with a high-gluten diet they experience less intestinal discomfort including less bloating which researchers show are due to changes of the composition and function of gut...
The already-rare Stone's sheep of the Yukon is 20 per cent less common than previously thought, according to new research by biologists. The study examined 123 different DNA...
A study using animal-attached technology to measure food consumption in four very different wild vertebrates has revealed that animals using a high-risk strategy to find rarer food are...
An analysis of Twitter data from the U.S. shows that social media usage largely mirrors daily work schedules and school calendars. The data reflect the amount...
Although the presence of humpback whales in the Mediterranean has been considered unusual, it is known that their visits have increased in the last 150 years. Until now, there had...
What in the smart nanomaterials world is widely available, highly symmetrical and inexpensive? Hollow carbon structures, shaped like a football, called fullerenes. Their applications range from artificial photosynthesis and nonlinear optics to the production of photoactive films and nanostructures. To...
Researchers at Lund University in Sweden have studied flight routes to determine how far willow warblers migrate in the autumn. The results show that the willow warbler holds a long-distance migration record in the ten-gram weight category –...
The textile industry generates enormous amounts of waste and is one of the largest consumers of water and energy resources. Research is looking at ways to reduce its ecological impact...
Scientists with different scientific backgrounds, working in the field of nanotechnology, have cooperated with the main objective to provide as broad an overview as possible about the young and rapidly evolving field of nanoinformatics.
Male salmon are maturing earlier and becoming smaller, and it shows in their genes. This was the discovery of a study that examined scale samples from salmon over a 40-year...
Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumors disappear in mice, making it...
VIDEO
Touch, or tactile sensing, is fundamentally important for a range of real-life applications, from robotics to surgical medicine to sports science. Tactile sensors are modeled on the biological sense of touch and can help...
An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers at the University of Zurich have now found that this happens through a previously unknown mechanism....
A genetic analysis of samples taken from a large UK health database suggest that people who are more sensitive than their peers to the bitter taste of caffeine tend to drink more coffee —...
Wherever there's water, there's bound to be bubbles floating at the surface. From standing puddles, lakes, and streams, to swimming pools, hot tubs, public fountains, and toilets, bubbles are ubiquitous, indoors and...
Researchers have found that a protein in the cell membranes of sperm plays a key role in how they find their way to eggs. The PMCA protein may also help...
Researchers have outlined a plan to detect and report changes in global biodiversity. The monitoring of species traits will improve natural resource management.
While making smart glue, a team of engineers discovered a handy byproduct: hydrogen peroxide. In microgel form, it reduces bacteria and virus ability to infect by at least 99.9 percent.
The majority of consumers, even those who prefer online shopping, think the extinction of brick-and-mortar stores would be bad for society, according to a...
Luxia Scientific, a French biotech dedicated to improving well-being and health for all through the analysis and understanding of the microbiome, announces the availability of its...
A fast new way of checking nutrient levels in grasslands allows farmers to quickly monitor changes in pasture nutrients and adapt their animals' grazing methods accordingly....
An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers at the University of Zurich have now found out that this happens through a previously unknown...
Many life-saving medicines, including insulin, antibodies and vaccines, are derived from living cells. These "biologics" can be difficult to obtain and store...
Call it instinct, but something compels some animals to behave in certain ways, perhaps programs in their genes. Researchers have directly connected activities of...
TGen North, the Pathogen and Microbiome Division of the Translational Genomics Research Institute, has partnered with the non-profit NARBHA Institute to advance human health through the new TGen...
While making smart glue, a team of engineers discovered a handy byproduct: hydrogen peroxide. In microgel form, it reduces bacteria and virus ability to infect by at least 99 percent.
A new article describes two new fossil relatives of marsupials that shed light on how a unique island ecosystem evolved some 43 million years ago during the Eocene.
When rains fell on the arid Atacama Desert, it was reasonable to expect floral blooms to follow. Instead, the water brought death. Planetary astrobiologists has found that after encountering never-before-seen rainfall three...
Truffles are the fruiting bodies of the ectomycorrhizal (ECM) fungal symbionts residing on host plant roots. In many Ascomycota and Basidiomycota lineages, truffle-forming species have evolved independently in nearly every major group. This suggests that symbiosis...
While the sight of black or white truffle being shaved over on pasta is generally considered a sign of dining extravagance, they play an important role in soil ecosystem services. Truffles are the fruiting bodies of...
In the most comprehensive study of its kind, biologists have found that tropical and subtropical forests across South America's Andes Mountains are responding to warming temperatures...
Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution...
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important...
One of the defining features of language is displaced reference—the capacity to transmit information about something that is not present or about a past or future event. It is very rare in nature and...
The mosquito Aedes aegypti is a powerful, plentiful species: It populates six continents, can carry deadly viruses, and bites with abandon. But until recently, its genome was in tatters.
An international study led by University of Miami tropical biologists reveals that tropical trees are migrating upslope to escape climate change, but not fast enough.
Many life-saving medicines, including insulin, antibodies and vaccines, are derived from living cells. These "biologics" can be difficult to obtain and store on the battlefield or in remote areas. That's why scientists are trying to develop portable systems that can...
According to a recent meta-analysis, soy protein is equally effective as animal protein in building muscle mass and strength. Undertaking resistance exercise is key in increasing...
Modern medicine's ability to keep us alive makes it tempting to think human evolution may have stopped. Better healthcare disrupts a key driving force of evolution by keeping...
Shopping in your supermarket's produce section is like strolling through a museum of humanity's greatest inventions. Perfect ears of golden sweet corn;...
Representing a group of successful biocontrol agents for various pest fruit flies, a parasitic wasp genus remains largely overlooked. While its most recent identification key dates back to 1969, many...
While making smart glue, a team of engineers discovered a handy byproduct: hydrogen peroxide. In microgel form, it reduces bacteria and virus ability to infect by at least 99 percent.
Male salmon are maturing earlier and becoming smaller, and it shows in their genes. This was the discovery of a study that examined scale samples from salmon in the River...
You probably learned this basic lesson of biology in elementary school: Plants are self-feeders. These so-called autotrophs use the sun's energy and water to turn carbon dioxide from the air...
The fin whale and mountain gorilla populations grew significantly due to efforts by conservationists to halt their descent towards extinction, the International Union for Conservation of Nature (IUCN) said Wednesday.
A team of researchers with Cornell University and the University of Oxford has found that birds and insects reacted in some surprising ways to the 2017 U.S. total solar eclipse....
Biodiversity goes beyond species diversity. Another important aspect of biodiversity is genetic variation within species. A notable example is the immense variety of cultivars and landraces of crop plants and their wild...
A team of researchers from Australia, Indonesia, Italy and Denmark has learned more about Komodo dragons in their search to better understand reduced island dispersal in...
Microbial plankton communities will be boosted in productivity and biomass from warmer water temperatures provided sufficient nutrients are also readily available, suggest KAUST researchers.
Microplastics have been recorded in a range of zooplankton species, and they are already causing problems for these tiny - but vitally important - animals, even before the plastic particles make their way through the food web. A new...
Zoologist Sarah Otto, with the University of British Columbia, has published a report in the journal Proceedings of the Royal Society B regarding human influence on evolution over...
On the eve of the recent National Drought Summit, prime minister Scott Morrison and deputy prime minister Michael McCormack visited Mulloon Creek near Canberra, shown recently on the ABC's Australian Story. They...
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