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UC San Diego researchers awarded two grants for investigating stem cell-based therapies
NEWS MEDICAL The governing board of the California Institute for Regenerative Medicine unanimously approved this week two grants worth more than $2.2 million to University of... 11 hours
TCR signal strength controls the differentiation of CD4+ effector and memory T cells
Science Magazine CD4+ T cell responses are composed of heterogeneous T cell receptor (TCR) signals that influence the acquisition of effector and memory characteristics.... 19 hours
Radical chain repair: The hydroalkylation of polysubstituted unactivated alkenes
Science Magazine The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress.... 19 hours
Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing
Science Magazine Wearable biosensors have emerged as an alternative evolutionary development in the field of healthcare technology due to their potential to change conventional medical diagnostics... 19 hours
FDA approves first drug for treatment of adult AML patients with specific genetic mutation
NEWS MEDICAL The U.S. Food and Drug Administration today approved Tibsovo (ivosidenib) tablets for the treatment of adult patients with relapsed or... 20 hours
Study looks into mechanisms that control sleep and wakefulness
NEWS MEDICAL Sleep is an autonomic process and is not always under our direct, voluntary control. Awake or asleep, we are basically under the regulation of two biological processes: sleep homeostasis, commonly... 21 hours
Scientists reverse aging-associated skin wrinkles and hair loss in a mouse model
SCIENCE DAILY Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. When a mutation leading to mitochondrial dysfunction is induced,... 21 hours
Effect of genetic factors on nutrition: The genes are not to blame
SCIENCE DAILY Individualized dietary recommendations based on genetic information are currently a popular trend. A team has systematically analyzed scientific articles and reached the following conclusion:... 21 hours
Fueling the MATE transporter
PHYS.ORG Evolutionarily conserved transport proteins, such as those belonging to the multidrug and toxic compound extrusion (MATE) superfamily, protect cells against toxic chemicals and contribute to multidrug resistance in cancer and bacterial cells. 22 hours
Why malaria parasites are faster than human immune cells
PHYS.ORG Elementary cytoskeleton protein is different in parasites and represents a starting point for a possible new therapy against malaria infections. Researchers from the Heidelberg University Hospital, the Centre for Molecular... 22 hours
New material: Two faces offer limitless possibilities
SCIENCE DAILY Named for the mythical god with two faces, Janus membranes -- double-sided membranes that serve as gatekeepers between two substances -- have emerged as a material with potential industrial uses. 22 hours
The cause of prostate cancer progression to incurable stage has likely been uncovered
SCIENCE DAILY Researchers have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences... 22 hours
Protecting autonomous grids from potentially crippling GPS spoofing attacks
SCIENCE DAILY Not long ago, getting a virus was about the worst thing computer users could expect in terms of system vulnerability. But in our current age of hyper-connectedness and the emerging... 22 hours
Gene regulator may contribute to protein pileup in exfoliation glaucoma
SCIENCE DAILY In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes. Scientists have evidence that variants of the same gene that enables us... 23 hours
How California's sea stars are evolving past a devastating pandemic
PHYS.ORG In 2012, environmental systems graduate student Lauren Schiebelhut was collecting DNA from ochre sea stars living along the Northern California coast—part of an effort to study genetic diversity... 23 hours
Researchers report two-faced Janus membrane applications
PHYS.ORG VIDEO Named for the mythical god with two faces, Janus membranes—double-sided membranes that serve as gatekeepers between two substances—have emerged as a material with potential industrial uses. Creating two distinct "faces" on these delicate surfaces, however, is... 23 hours
Scientists explore new experimental model systems to advance biology
PHYS.ORG Tremendous advancement of basic biological knowledge has come from genetically manipulating model organisms to test mechanistic hypotheses. But the selection of traditional model organisms available offers a limited view of... 23 hours
Genome damage from CRISPR/Cas9 gene editing higher than thought
SCIENCE DAILY Scientists have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. This has safety implications for future gene therapies using CRISPR/Cas9 as the... 23 hours
AVITA Medical expands management team to support launch of RECELL device to treat burns
NEWS MEDICAL AVITA Medical today announced that it expanded its management team in the commercial, legal and medical affairs functions to support... 23 hours
Karius Test accurately detects invasive fungal infections, shows study
NEWS MEDICAL Karius, a life sciences company transforming infectious disease diagnostics with genomics and data through the innovative use of next-generation sequencing to analyze microbial cell-free DNA, announced today the positive results... 23 hours
Diabetes during pregnancy may increase baby's heart disease risk
SCIENCE DAILY Gestational diabetes may increase the risk of blood vessel dysfunction and heart disease in offspring by altering a smooth muscle protein responsible for blood vessel network formation. Understanding of the... 24 hours
Researchers uncover cause for progression of prostate cancer to incurable stage
NEWS MEDICAL Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism... 24 hours
Arctic geese speed up their migration in response to increasing temperatures
NEWS MEDICAL As Arctic temperatures continue to rise, migratory barnacle geese have responded by speeding up their 3,000-kilometer migration in order to reach their destination more quickly with... 24 hours
Researchers present evidence of phage cooperation when attacking CRISPR-containing bacteria
NEWS MEDICAL CRISPR, or clustered regularly interspaced short palindromic repeats, are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it... 24 hours
Putting bacteria to work
PHYS.ORG The idea of bacteria as diverse, complex perceptive entities that can hunt prey in packs, remember past experiences and interact with the moods and perceptions of their human hosts sounds like the plot of some low-budget science fiction movie. But... 1 day
New findings on intercellular communication
PHYS.ORG Led by Benoit Vanhollebeke, WELBIO investigator at the Université libre de Bruxelles (ULB), the Laboratory of Neurovascular Signaling has solved an important enigma of cell signaling related to Wnt signaling specificity. 1 day
CRISPR-based tool maps gene function in human cells
PHYS.ORG UC San Francisco scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail. 1 day
LC10 – the neuron that tracks fruit flies
PHYS.ORG Many animals rely on vision to detect, locate, and track moving objects. Male Drosophila fruit flies primarily use visual cues to stay close to a female and to direct their courtship song... 1 day
Scientists find reason why malarial parasites are faster than immune cells
NEWS MEDICAL Elementary cytoskeleton protein is different in parasites and represents a starting point for a possible new therapy against malaria infections. 1 day
Study finds key to plant growth control mechanism
PHYS.ORG A Purdue University study has mapped a complex series of pathways that control the shape of plant cells. The findings are an important step toward customizing how plants grow to suit particular... 1 day
Targeting headaches and tumors with nano-submarines
PHYS.ORG Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack... 1 day
Scientists develop proteins that self-assemble into supramolecular complexes
PHYS.ORG A collaborative research team based in Japan has designed new proteins that can self-assemble into the complex structures underlying biological organisms, laying the groundwork for leading-edge applications in biotechnology. The researchers created... 1 day
Mixed mRNA tails act like a shield to delay its shortening
PHYS.ORG Cells curb the amount of specific proteins at any desired time via the control of mRNA degradation. As mRNA nucleotides tail plays a role in this... 1 day
Mixed mRNA tails act like a shield that delays its shortening
PHYS.ORG Cells curb the amount of specific proteins at any desired time via the control of mRNA degradation. As mRNA nucleotides tail plays a role in this... 1 day
Gene therapy may hold potential to treat people with spinal cord injuries
NEWS MEDICAL Delivering a single injection of a scar-busting gene to the spinal cord of rats following injury promotes the survival of nerve cells and improves... 1 day
New vaccine could protect unborn babies from Zika virus
NEWS MEDICAL Until recently, the Zika virus was not a priority since it affected relatively few people and the cost of creating a vaccine was estimated at EUR 149-468 million. But the... 1 day
$1M award for Salk scientist Janelle Ayres, who befriends our microbial enemies
PHYS.ORG Janelle Ayres, a rising star at the Salk Institute for Biological Studies in San Diego, has collected her second honor in a month—one which... 1 day
Dr Maddy Parsons receives Royal Microscopical Society Life Science Medal
NEWS MEDICAL Dr Maddy Parsons, a Group Leader in the Randall Division of Cell & Molecular Biophysics, has been awarded the Royal Microscopical Society Life Science Medal for her outstanding... 1 day
Researchers design proteins that can self-assemble into complex structures
NEWS MEDICAL A collaborative research team based in Japan has designed new proteins that can self-assemble into the complex structures underlying biological organisms, laying the groundwork for leading-edge applications in biotechnology. 1 day
Genetic sequencing reveals new clues to aggressiveness of prostate cancer
NEWS MEDICAL Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. 1 day
Researchers identify enzyme as potential new drug target for blood disorders
NEWS MEDICAL Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to... 1 day
Novel tool predicts genes that cause disease due to production of truncated proteins
NEWS MEDICAL Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different... 1 day
Researchers raise viability of cloned mice using somatic cell nuclear transfer method
NEWS MEDICAL An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating... 1 day
Using miniature drug-filled nanocarriers to target headaches and tumors
NEWS MEDICAL Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune... 1 day
Phages work together to suppress CRISPR bacterial immunity
SCIENCE DAILY CRISPR are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it does in human cells as a pair of scissors, in their... 2 days
Chemists characterize the fatal fungus among us
SCIENCE DAILY Life-threatening fungal infections affect more than two million people worldwide. Effective antifungal medications are limited. A major challenge is that the fungal cell wall is poorly understood, which has impeded drug development. However, chemist... 2 days
Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia
SCIENCE DAILY Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative... 2 days
Discovery of kidney cancer driver could lead to new treatment strategy
SCIENCE DAILY Researchers suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer. 2 days
Mixed mRNA tails act like a shield that delays its shortening
SCIENCE DAILY Biologists have identified how mixed tails -- made of different nucleotides -- protect mRNA from degradation for longer. This study could bring new insights to our... 2 days
Why does making new egg cells require so much cell death?
SCIENCE DAILY A highly detailed study of how the roundworm C. elegans forms oocytes suggests that the egg-making process leads to the formation and subsequent destruction of cells... 2 days
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
Science Magazine Receptor Interacting Serine/Threonine Kinase 1 (RIPK1) is a master regulator of signaling pathways leading to inflammation and cell death and is of medical interest... 2 days
A molecular mechanism for Wnt ligand-specific signaling
Science Magazine Wnt signaling is key to many developmental, physiological and disease processes, in which cells seem able to discriminate between multiple Wnt ligands. This selective Wnt recognition or "decoding" capacity has remained enigmatic as Wnt/Frizzled... 2 days
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation
Science Magazine RNA tails play integral roles in the regulation of mRNA translation and decay. Guanylation of poly(A) tail was discovered recently, yet the enzymology and function remain... 2 days
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Science Magazine Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and... 2 days
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma
Science Magazine Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear cell renal cell... 2 days
Chemists characterize the fatal fungus among us
PHYS.ORG Life-threatening fungal infections affect more than two million people worldwide. Effective antifungal medications are very limited. Until now, one of the major challenges is that the fungal cell wall is poorly understood, which has... 2 days
Potential new MS drug could regenerate myelin
MNT A study finds that blocking the M3R receptor improves myelination in mice implanted with human progenitor cells, maybe leading to clinical trials in MS. 2 days
Medical News Today: Potential new MS drug could regenerate myelin
MNT A study finds that blocking the M3R receptor improves myelination in mice implanted with human progenitor cells, maybe leading to clinical trials in MS. 2 days
Scientists surmount epigenetic barriers to cloning with two-pronged approach
PHYS.ORG An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating two epigenetic factors, and by doing... 2 days
Targeting headaches and tumors with nano-submarines
SCIENCE DAILY VIDEO Scientists have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors. 2 days
Depression-induced inflammation during pregnancy may impact newborns
SCIENCE DAILY The physiological impacts of depression on pregnant mothers may affect babies while in the womb and lead to changes in the behavior and biology of newborns, finds new research. 2 days
'Alien' Mummy DNA Probe May Have Crossed Ethical Lines
LIVE SCIENCE Did DNA analysis of an "alien" mummy violate legal and ethical boundaries? 2 days
Scientists develop proteins that self-assemble into supramolecular complexes
SCIENCE DAILY Scientists have designed new proteins that can self-assemble into the complex structures underlying biological organisms, laying the groundwork for leading-edge applications in biotechnology. The researchers created and developed the proteins with a... 2 days
This colorful web is the most complete look yet at a fruit fly’s brain cells
SCIENCE-NEWS VIDEO Scientists compiled 21 million images to craft the highest-resolution view yet of the fruit fly brain. 2 days
Health of mom's gut a key contributor to autism risk, study suggests
SCIENCE DAILY The mother's microbiome, the collection of microscopic organisms that live inside us, is a key contributor to the risk of autism and other neurodevelopmental... 2 days
AP-NORC Poll: If DNA shows health risks, most want to know
ABC NEWS AP-NORC Poll: Curiosity about ancestry is the main reason Americans seek DNA testing but many also want to know if they're at risk for disease 2 days
In a warming climate, Arctic geese are rushing north
PHYS.ORG As Arctic temperatures continue to rise, migratory barnacle geese have responded by speeding up their 3,000-kilometer migration in order to reach their destination more quickly with fewer stops along the... 2 days
Viruses cooperate to overcome immune defences of bacteria
PHYS.ORG Virus particles that infect bacteria can work together to overcome antiviral defences, new research shows. 2 days
Phages work together to suppress CRISPR bacterial immunity
PHYS.ORG CRISPR, or clustered regularly interspaced short palindromic repeats, are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it does in human cells... 2 days
The effectiveness of chlorhexidine is limited in preventing infections in oral procedures
SCIENCE DAILY A large number of bacteria are present in human mouths and may pass into the blood when procedures such as the removal of a... 2 days
Aggressive immune cells aggravate Parkinson's disease
SCIENCE DAILY Parkinson's disease, formerly also referred to as shaking palsy, is one of the most frequent disorders affecting movement and the nervous system. Medical researchers have come across a possible cause of the disease - in the... 2 days
Scientists uncover the role of a protein in production and survival of myelin-forming cells
SCIENCE DAILY A new article explains how researchers have uncovered the role of a protein known as 'PRMT5' in the production of... 2 days
Kite collaborates with Gadeta to develop novel gamma delta TCR therapies for various cancers
NEWS MEDICAL Kite, a Gilead Company, and Gadeta B.V., a privately-held company focused on the discovery and development of novel cancer immunotherapies... 2 days
Will hydrogen-powered cars gradually become mainstream in Europe?
PHYS.ORG An EU initiative will deploy hydrogen fuel cell electric vehicles in three European capitals as taxis, private-hire and police cars. The move will accelerate their commercialisation and help realise emissions-free transport. 2 days
Using elements in plants to increase fuel cell efficiency while reducing costs
PHYS.ORG Researchers from the Institut National de la Recherche Scientifique, Québec are looking into reeds, tall wetlands plants, in order to make cheaper catalysts for... 2 days
Study uncovers new protein complex that shields broken DNA ends
NEWS MEDICAL Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for the treatment of cancer. 2 days
Gene regulator associated with protein pileup in exfoliation glaucoma
NEWS MEDICAL In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes. 2 days
Study finds link between DNA methylation and non-alcoholic fatty liver disease
NEWS MEDICAL DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But... 2 days
Study identifies RNA molecules that regulate male hormones in prostate cancer
NEWS MEDICAL In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone. 2 days
Scientists study adverse effects of carbon, silicon nanotubes and carbon nanofibers
NEWS MEDICAL Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. This algae species is widely spread in the Russian Far... 2 days
New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis
NEWS MEDICAL The brains of people with Alzheimer's disease contain many protein aggregates outside of cells, known as plaques. These are mainly made of the peptide... 2 days
Scientists develop synthetic biology-inspired materials systems
NEWS MEDICAL Scientists from the University of Freiburg have developed materials systems that are composed of biological components and polymer materials and are capable of perceiving and processing information. 2 days
Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing
NEWS MEDICAL Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center and The Jackson Laboratory have... 2 days
Researchers find mugwort pollen as major source of airborne endotoxins
NEWS MEDICAL A wide range of airborne substances can cause respiratory problems for asthma sufferers. These include bacteria and their components, which can trigger inflammations. 2 days
Mother's microbiome determines offspring's risk of developing autism
NEWS MEDICAL The risk of developing autism-spectrum disorders is determined by the mother's microbiome - the collection of microorganisms that naturally live inside us - during pregnancy, new research from the University of Virginia... 2 days
DNA methylation related to liver disease among obese patients, study shows
SCIENCE DAILY Researchers have identified how DNA methylation is associated with a condition known as non-alcoholic fatty liver disease (NAFLD), which can lead to liver cirrhosis and death,... 3 days
RNA molecules that regulate action of male hormone in prostate cancer identified
SCIENCE DAILY A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors... 3 days
Scientists uncover DNA 'shield' w/crucial roles in normal cell division
SCIENCE DAILY New fundamental complex in cells drives 'messy' form of DNA repair. In immune cells, this is crucial to make antibodies. In cancer, mutations in complex could lead to... 3 days
Glowing bacteria on deep-sea fish shed light on evolution, 'third type' of symbiosis
SCIENCE DAILY For the first time, scientists have sequenced and analyzed the genomes of bacteria that live in anglerfish bulbs. The bacteria were taken... 3 days
Origami-inspired device helps marine biologists study octopuses and jellyfish
SCIENCE DAILY Scientists have tried to find the safest and most effective ways to explore marine life in the oceanic water, the largest and least explored environment on Earth, for years. Each... 3 days
Glowing bacteria on deep-sea fish shed light on evolution, 'third type' of symbiosis
PHYS.ORG You may recognize the anglerfish from its dramatic appearance in the hit animated film Finding Nemo, as it was very nearly the... 3 days
Researchers solve mystery of how ALL enters the central nervous system
SCIENCE DAILY A deadly feature of acute lymphoblastic leukemia (ALL) is its invasion of the central nervous system. ALL in the central nervous system is very difficult to... 3 days
Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling
Science Magazine Hematopoietic stem/progenitor cell (HSPC) homing occurs via cell adhesion mediated by spatiotemporally organized ligand-receptor interactions. Although molecules and biological processes involved in this multistep cellular interaction... 3 days
[Research Articles] Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo
Science Magazine Vitiligo is an autoimmune disease of the skin mediated by CD8+ T cells that kill melanocytes and create white spots.... 3 days
[Editors' Choice] A cytokine duet regulates inflammatory bowel disease
Science Magazine Inhibition of IL-17F, but not IL-17A, promotes microbiota-mediated regulatory T cell generation in the colon and ameliorates intestinal inflammation in mice. 3 days
[Research Articles] PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
Science Magazine Kinase inhibitor resistance constitutes a major unresolved clinical challenge in cancer. Furthermore, the role of serine/threonine... 3 days
[Editors' Choice] A bullet against gallbladder cancer
Science Magazine ERBB2/3 mutations in gallbladder cancer are associated with immunosuppression and aggressive tumor development and can be targeted by ERBB2/3 inhibitors. 3 days
[Editors' Choice] Re-engineering the heart with the correct components
Science Magazine Modulation of retinoic acid signaling generates atrial versus ventricular cardiomyocytes from human induced pluripotent stem cells. 3 days
[Research Articles] MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma
Science Magazine Combination anti–cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti–programmed cell death protein 1 (PD-1) therapy promotes... 3 days
Researchers report two-faced Janus membrane applications
PHYS.ORG
This colorful web is the most complete look yet at a fruit fly’s brain cells
SCIENCE-NEWS
Targeting headaches and tumors with nano-submarines
SCIENCE DAILY
Scientists show how energy landscape algorithm details DNA's interphase dynamics
PHYS.ORG
Fluorescent fish genes light path to neuroblastoma
PHYS.ORG
New patch boosts brightness in medical diagnostic tests
PHYS.ORG
Will Smith hosts National Geographic's "One Strange Rock"
Parallel State