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UC San Diego researchers awarded two grants for investigating stem cell-based therapies
NEWS MEDICAL The governing board of the California Institute for Regenerative Medicine unanimously approved this week two grants worth more than $2.2 million to University of... 10 hours
Here’s the sexual harassment report that felled a famed geneticist—and his defense
Science Magazine Even after he was asked to stop, Francisco Ayala repeatedly directed unwelcome attention toward women, university found 13 hours
Radical chain repair: The hydroalkylation of polysubstituted unactivated alkenes
Science Magazine The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress.... 19 hours
FDA approves first drug for treatment of adult AML patients with specific genetic mutation
NEWS MEDICAL The U.S. Food and Drug Administration today approved Tibsovo (ivosidenib) tablets for the treatment of adult patients with relapsed or... 19 hours
Scientists reverse aging-associated skin wrinkles and hair loss in a mouse model
SCIENCE DAILY Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. When a mutation leading to mitochondrial dysfunction is induced,... 21 hours
Pathogens attack plants like hackers, so my lab thinks about crop protection like cybersecurity
PHYS.ORG Plants feed us. Without them we're goners. Through thousands of years of genetic modification by selective breeding, humans have developed... 21 hours
Effect of genetic factors on nutrition: The genes are not to blame
SCIENCE DAILY Individualized dietary recommendations based on genetic information are currently a popular trend. A team has systematically analyzed scientific articles and reached the following conclusion:... 21 hours
Support for the Endangered Species Act remains high as Trump administration and Congress try to gut it
PHYS.ORG The Endangered Species Act, or "the Act," is arguably the most important law in... 22 hours
The cause of prostate cancer progression to incurable stage has likely been uncovered
SCIENCE DAILY Researchers have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences... 22 hours
Gene regulator may contribute to protein pileup in exfoliation glaucoma
SCIENCE DAILY In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes. Scientists have evidence that variants of the same gene that enables us... 23 hours
How California's sea stars are evolving past a devastating pandemic
PHYS.ORG In 2012, environmental systems graduate student Lauren Schiebelhut was collecting DNA from ochre sea stars living along the Northern California coast—part of an effort to study genetic diversity... 23 hours
Scientists explore new experimental model systems to advance biology
PHYS.ORG Tremendous advancement of basic biological knowledge has come from genetically manipulating model organisms to test mechanistic hypotheses. But the selection of traditional model organisms available offers a limited view of... 23 hours
Genome damage from CRISPR/Cas9 gene editing higher than thought
SCIENCE DAILY Scientists have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. This has safety implications for future gene therapies using CRISPR/Cas9 as the... 23 hours
Karius Test accurately detects invasive fungal infections, shows study
NEWS MEDICAL Karius, a life sciences company transforming infectious disease diagnostics with genomics and data through the innovative use of next-generation sequencing to analyze microbial cell-free DNA, announced today the positive results... 23 hours
Researchers uncover cause for progression of prostate cancer to incurable stage
NEWS MEDICAL Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism... 24 hours
Researchers present evidence of phage cooperation when attacking CRISPR-containing bacteria
NEWS MEDICAL CRISPR, or clustered regularly interspaced short palindromic repeats, are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it... 24 hours
New findings on intercellular communication
PHYS.ORG Led by Benoit Vanhollebeke, WELBIO investigator at the Université libre de Bruxelles (ULB), the Laboratory of Neurovascular Signaling has solved an important enigma of cell signaling related to Wnt signaling specificity. 24 hours
CRISPR-based tool maps gene function in human cells
PHYS.ORG UC San Francisco scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail. 24 hours
Mixed mRNA tails act like a shield to delay its shortening
PHYS.ORG Cells curb the amount of specific proteins at any desired time via the control of mRNA degradation. As mRNA nucleotides tail plays a role in this... 1 day
Mixed mRNA tails act like a shield that delays its shortening
PHYS.ORG Cells curb the amount of specific proteins at any desired time via the control of mRNA degradation. As mRNA nucleotides tail plays a role in this... 1 day
Gene therapy may hold potential to treat people with spinal cord injuries
NEWS MEDICAL Delivering a single injection of a scar-busting gene to the spinal cord of rats following injury promotes the survival of nerve cells and improves... 1 day
Genetic sequencing reveals new clues to aggressiveness of prostate cancer
NEWS MEDICAL Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. 1 day
Novel tool predicts genes that cause disease due to production of truncated proteins
NEWS MEDICAL Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different... 1 day
Researchers raise viability of cloned mice using somatic cell nuclear transfer method
NEWS MEDICAL An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating... 1 day
ZHX2 protein could offer a new treatment strategy for kidney cancer
NEWS MEDICAL University of North Carolina Lineberger Comprehensive Cancer Center scientists have uncovered a potential therapeutic target for kidney cancers that have a common genetic change. 1 day
Phages work together to suppress CRISPR bacterial immunity
SCIENCE DAILY CRISPR are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it does in human cells as a pair of scissors, in their... 1 day
Star Wars: Clone Wars Revived for Surprise Seventh Season
SPACE.COM The animated series Star Wars: The Clone Wars is being revived for a surprise seventh season on the upcoming Disney streaming service. 2 days
Mixed mRNA tails act like a shield that delays its shortening
SCIENCE DAILY Biologists have identified how mixed tails -- made of different nucleotides -- protect mRNA from degradation for longer. This study could bring new insights to our... 2 days
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
Science Magazine Receptor Interacting Serine/Threonine Kinase 1 (RIPK1) is a master regulator of signaling pathways leading to inflammation and cell death and is of medical interest... 2 days
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation
Science Magazine RNA tails play integral roles in the regulation of mRNA translation and decay. Guanylation of poly(A) tail was discovered recently, yet the enzymology and function remain... 2 days
Modeling the ecology and evolution of biodiversity: Biogeographical cradles, museums, and graves
Science Magazine Individual processes shaping geographical patterns of biodiversity are increasingly understood, but their complex interactions on broad spatial and temporal scales remain beyond the reach... 2 days
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Science Magazine Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and... 2 days
Fruit fly species can learn each other's dialects
PHYS.ORG Fruit flies from different species can warn each other when parasitic wasps are near. But according to a new study led by Balint Z. Kacsoh of Geisel School of Medicine at Dartmouth,... 2 days
From cradle to grave: Model identifies factors that shaped evolution
PHYS.ORG Understanding the many factors that have played into shaping the biodiversity within Earth's ecosystems can be daunting. In a major step to that end, an international team of... 2 days
Scientists surmount epigenetic barriers to cloning with two-pronged approach
PHYS.ORG An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating two epigenetic factors, and by doing... 2 days
'Alien' Mummy DNA Probe May Have Crossed Ethical Lines
LIVE SCIENCE Did DNA analysis of an "alien" mummy violate legal and ethical boundaries? 2 days
AP-NORC Poll: If DNA shows health risks, most want to know
ABC NEWS AP-NORC Poll: Curiosity about ancestry is the main reason Americans seek DNA testing but many also want to know if they're at risk for disease 2 days
In a ‘tour de force,’ researchers image an entire fly brain in minute detail
Science Magazine VIDEO Electron microscopy offers synapse-level view of the largest whole brain to date 2 days
Phages work together to suppress CRISPR bacterial immunity
PHYS.ORG CRISPR, or clustered regularly interspaced short palindromic repeats, are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it does in human cells... 2 days
New greener and more efficient noise barriers
PHYS.ORG Researchers from Universidad Politécnica de Madrid (UPM) have developed a new vegetal and affordable noise barrier that significantly reduces both noise and the environmental and landscape impact. 2 days
Using elements in plants to increase fuel cell efficiency while reducing costs
PHYS.ORG Researchers from the Institut National de la Recherche Scientifique, Québec are looking into reeds, tall wetlands plants, in order to make cheaper catalysts for... 2 days
Study uncovers new protein complex that shields broken DNA ends
NEWS MEDICAL Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for the treatment of cancer. 2 days
Gene regulator associated with protein pileup in exfoliation glaucoma
NEWS MEDICAL In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes. 2 days
Study finds link between DNA methylation and non-alcoholic fatty liver disease
NEWS MEDICAL DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But... 2 days
Study identifies RNA molecules that regulate male hormones in prostate cancer
NEWS MEDICAL In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone. 2 days
Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing
NEWS MEDICAL Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center and The Jackson Laboratory have... 2 days
DNA methylation related to liver disease among obese patients, study shows
SCIENCE DAILY Researchers have identified how DNA methylation is associated with a condition known as non-alcoholic fatty liver disease (NAFLD), which can lead to liver cirrhosis and death,... 3 days
RNA molecules that regulate action of male hormone in prostate cancer identified
SCIENCE DAILY A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors... 3 days
Scientists uncover DNA 'shield' w/crucial roles in normal cell division
SCIENCE DAILY New fundamental complex in cells drives 'messy' form of DNA repair. In immune cells, this is crucial to make antibodies. In cancer, mutations in complex could lead to... 3 days
Robust estimates of a high Ne/N ratio in a top marine predator, southern bluefin tuna
Science Magazine Genetic studies of several marine species with high fecundity have produced "tiny" estimates (≤10–3) of the ratio of... 3 days
[Research Articles] PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
Science Magazine Kinase inhibitor resistance constitutes a major unresolved clinical challenge in cancer. Furthermore, the role of serine/threonine... 3 days
[Editors' Choice] A bullet against gallbladder cancer
Science Magazine ERBB2/3 mutations in gallbladder cancer are associated with immunosuppression and aggressive tumor development and can be targeted by ERBB2/3 inhibitors. 3 days
New breast cancer therapeutic target
SCIENCE DAILY Research has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer. 3 days
Faulty science and ethics cited in DNA analyzes of Atacama mummy
SCIENCE DAILY Researchers call into question the ethics and skeletal and genomic analysis surrounding research into the much publicized 'Atacama mummy'. 3 days
Research uncovers new target for therapeutic intervention in breast cancer
NEWS MEDICAL Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a... 3 days
Lateral gene transfer enables chemical protection of beetles against antagonistic fungi
SCIENCE DAILY Researchers have discovered that bacteria associated to Lagria villosa beetles can produce an antifungal substance very similar to one found in tunicates living in the marine... 3 days
New retinal ganglion cell subtypes emerge from single-cell RNA sequencing
SCIENCE DAILY Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers have now identified 40 subtypes of retinal ganglion cells (RGCs) along with the genetic... 3 days
Research cites faulty science and ethics in DNA analyzes of 'Ata'
PHYS.ORG University of Otago-led international collaborative research calls into question the ethics and skeletal and genomic analysis surrounding research into the much publicised alien-like "Atacama mummy". 3 days
New strategy may lead to more accurate breast cancer diagnoses
NEWS MEDICAL A study in Molecular Oncology indicates that examining the protein and RNA in leftover materials from routine diagnostic tests for breast cancer may lead to more accurate diagnoses. 3 days
AMSBIO introduces new, powerful CRISPR/Cas9 gene editing kits
NEWS MEDICAL AMSBIO has introduced new CRISPR / Cas9 editing kits for gene knock-out, gene knock-in and gene mutation applications. 3 days
Single genetic change in gut bacteria can lead to obesity
NEWS MEDICAL A new study has shown that a single genetic change in a bacterium of the gut microbiome can lead to metabolic diseases such as obesity. 3 days
Lateral gene transfer enables chemical protection of beetles against antagonistic fungi
PHYS.ORG Like all other living organisms, animals face the challenge of fending off enemies. Using chemical weaponry can be an effective strategy to stay alive. Instead of... 3 days
Deleting single gene in gut bacteria affects metabolism, reduces weight gain in mice
NEWS MEDICAL Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight... 3 days
New platform poised to be next generation of genetic medicines
SCIENCE DAILY Scientists have discovered a gene-editing technology that could efficiently and accurately correct the genetic defects that underlie certain diseases, positioning the new tool as the basis for the... 4 days
UK-Based Think Tank Says Editing Human Embryos Is 'Morally Permissible'
LIVE SCIENCE Could gene editing be used to cut out harmful genes in human embryos? 4 days
A single genetic change in gut bacteria alters host metabolism
SCIENCE DAILY Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice. 4 days
New cost-effective instrument measures molecular dynamics on a picosecond timescale
SCIENCE DAILY Studying the photochemistry has shown that ultraviolet radiation can set off harmful chemical reactions in the human body and, alternatively, can provide 'photo-protection' by dispersing extra energy. To... 4 days
A single genetic change in gut bacteria alters host metabolism
PHYS.ORG Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice, according to a... 4 days
Large international study finds new risk genes for hay fever
NEWS MEDICAL In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the... 4 days
New cost-effective instrument measures molecular dynamics on a picosecond timescale
PHYS.ORG Studying the photochemistry, or chemical results of light, has shown that ultraviolet radiation can set off harmful chemical reactions in the human body and, alternatively, can provide "photo-protection"... 4 days
Impact of temperature on mitochondrial DNA evolution
SCIENCE DAILY A new study provides evidence towards selection in mtDNA due to variations in temperature. 4 days
Variations of a single gene drive diverse pigeon feather patterns
SCIENCE DAILY Biologists have discovered that different versions of a single gene, called NDP (Norrie Disease Protein), have unexpected links between color patterns in pigeons, and vision defects in humans.... 4 days
The depths of the ocean and gut flora unravel the mystery of microbial genes
SCIENCE DAILY Surprisingly, the functions of a huge number of microbial genes are still unknown. This knowledge gap can be thought of... 4 days
World's largest study on allergic rhinitis reveals new risk genes
SCIENCE DAILY Scientists have presented the largest study so far on allergic rhinitis. The data of nearly 900,000 participants revealed loci in the human genome whose changes significantly increase the... 4 days
Study identifies new genes linked to heart function and development
NEWS MEDICAL A new study from an international research team, led by Dr Yalda Jamshidi at St George's, University of London, has identified new genes associated with heart function and... 4 days
Researchers develop machine learning method to predict unknown gene functions of microbes
NEWS MEDICAL An international team led by computational biologist Fran Supek at IRB Barcelona develop a machine learning method to predict unknown gene functions of microbes. 4 days
Study reveals new risk genes for allergic rhinitis
NEWS MEDICAL An international team of scientists led by Helmholtz Zentrum München and University of Copenhagen has presented the largest study so far on allergic rhinitis in the journal 'Nature Genetics'. 4 days
Michigan's most endangered species nears extinction in one county
PHYS.ORG At an idyllic, quiet, tranquil patch of fen and prairie in Oakland County's Springfield Township, a tragedy is unfolding. 4 days
Variations of a single gene drive diverse pigeon feather patterns
PHYS.ORG In a new study, a team led by University of Utah biologists has discovered that different versions of a single gene, called NDP (Norrie Disease Protein), have unexpected... 4 days
The depths of the ocean and gut flora unravel the mystery of microbial genes
PHYS.ORG Understanding the functions of genes in bacteria that form part of the human microbiome—the collection of microbes found inside our... 4 days
Study demonstrates impact of temperature on mitochondrial DNA evolution
PHYS.ORG A new study by researchers at Okinawa Institute of Science and Technology Graduate University (OIST), provides evidence towards selection in mtDNA due to variations in temperature. 4 days
CRISPR/Cas9 gene editing scissors are less accurate than we thought, but there are fixes
PHYS.ORG CRISPR gene editing technology is revolutionising medicine and biology. This technique allows scientists to edit DNA with more precision and... 4 days
Staggering prices slow insurers’ coverage of CAR-T cancer therapy
NEWS MEDICAL Patients whose blood cancers have failed to respond to repeated rounds of chemotherapy may be candidates for a new type of gene therapy that could send their cancers into remission... 4 days
Genetically engineered eggplant improving lives in Bangladesh
PHYS.ORG Ansar Ali earned just 11,000 taka – about $130 U.S. dollars – from eggplant he grew last year in Bangladesh. This year, after planting Bt eggplant, he brought home more than double that amount,... 4 days
New research lays foundation to create standards for RNA sequencing
NEWS MEDICAL The idea of testing blood or urine to find markers that help diagnose or treat disease holds great promise. But as technology has improved to allow researchers to... 4 days
Aquatic Alga Genome Contains Ancient Land Plant Genes
SCI-NEWS.COM An international team of researchers, led by Kanazawa and Kobe Universities, Japan, and the Universities of Marburg and Freiburg, Germany,... 4 days
New machine learning framework predicts effects of genetic mutations in ‘dark matter’ regions
NEWS MEDICAL A new machine learning framework, dubbed ExPecto, can predict the effects of genetic mutations in the so-called "dark matter" regions of the... 4 days
Scientists identify hidden signals in RNAs that control protein synthesis
NEWS MEDICAL Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA-;A, U, C, and Gs-;form a blueprint for the protein-making machinery in... 4 days
Study findings highlight importance of early detection of SMA through newborn screening
NEWS MEDICAL Spinal muscular atrophy is a genetic disease that affects motor neurons in the spinal cord, resulting in muscle atrophy and widespread weakness that eventually... 4 days
YCC researchers suggest promising treatment for two rare inherited cancer syndromes
NEWS MEDICAL Studying two rare inherited cancer syndromes, Yale Cancer Center scientists have found the cancers are driven by a breakdown in how cells repair their DNA. 4 days
Heritable genome editing: Action needed to secure responsible way forward
SCIENCE DAILY An independent inquiry has concluded that editing the DNA of a human embryo, sperm, or egg to influence the characteristics of a future person ('heritable genome editing') could... 5 days
What to know about macrocephaly
MNT Macrocephaly is the term for an unusually large head. This can occur due to a family history of the condition, or it could indicate an underlying medical problem, such as a genetic syndrome. In this article, learn about... 5 days
Medical News Today: What to know about macrocephaly
MNT Macrocephaly is the term for an unusually large head. This can occur due to a family history of the condition, or it could indicate an underlying medical problem, such as a genetic... 5 days
New ALS therapy in clinical trials
SCIENCE DAILY New research indicates an investigational therapy for an inherited form of ALS extends survival and reverses signs of neuromuscular damage in mice and rats. The findings have led to a phase one/two clinical trial to investigate... 5 days
CRISPR Gene Editing May Be Doing More Damage Than Scientists Thought
LIVE SCIENCE In 15 percent of cases, cellular DNA was so scrambled that the cells lost function. 5 days
Cancer researchers suggest new treatment for rare inherited cancers
SCIENCE DAILY Studying two rare inherited cancer syndromes, scientists have found the cancers are driven by a breakdown in how cells repair their DNA. The discovery suggests a promising strategy for treatment... 5 days
Overcoming a major barrier to developing liquid biopsies
SCIENCE DAILY An international consortium tested nine different methods for RNA sequencing to understand and standardize the best way to sequence small RNAs. The goal was to create a process that could be reproduced... 5 days
Single-celled architects inspire new nanotechnology
SCIENCE DAILY Scientists have designed a range of nanostructures resembling marine diatoms -- tiny unicellular creatures. To achieve this, they borrow techniques used by naturally-occurring diatoms to deposit layers of silica -- the primary constituent in glass -- in order... 5 days
CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought
NEWS MEDICAL Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create... 5 days
In a ‘tour de force,’ researchers image an entire fly brain in minute detail
Science Magazine
Scientists show how energy landscape algorithm details DNA's interphase dynamics
PHYS.ORG
Fluorescent fish genes light path to neuroblastoma
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